Severity predictors for multisystemic inflammatory syndrome in children after SARS-CoV-2 infection in Vietnam

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 9, 2024

Abstract Multisystemic inflammatory syndrome in children (MIS-C) might manifest a broad spectrum of clinical scenarios, ranging from mild features to multi-organ dysfunction and mortality. However, this novel entity has heterogenicity data regarding prognostic factors associated with severe outcomes. The present study aimed identify independent predictors for severity by using multivariate regression models. A total 391 patients (255 boys 136 girls) were admitted Vietnam National Children’s Hospital January 2022 June 2023. median age was 85 (range: 2–188) months, only 12 (3.1%) had comorbidities. 161 (41.2%) required PICU admission, the LOS 4 (2–7) days. We observed related including CRP $$\ge $$ ≥ 50 (mg/L) (OR 2.52, 95% CI 1.39–4.56, p = 0.002), albumin $$\le ≤ 30 (g/L) 3.18, 1.63–6.02, 0.001), absolute lymphocyte count 2 (× 10 9 /L) 2.18, 1.29–3.71, 0.004), ferritin ≥ 300 (ng/mL) 2.35, 1.38–4.01), LVEF < 60 (%) 2.48, 1.28–4.78, 0.007). Shock developed 140 (35.8%) patients, especially those decreased 1.10–5.61, 0.029), 2.53, 1.22–5.24, 0.013), or 2.24, 1.12–4.51, 0.022). In conclusion, our emphasized that count, serum albumin, CRP, MIS-C severity. Further well-designed investigations are validate their efficacy predicting cases, compared other parameters. As is new courses may progress aggressively, identifying high-risk optimizes clinicians' follow-up management improve disease

Язык: Английский

Severity Predictors for Multisystemic Inflammatory in Children after SARS-CoV-2 Infection: A Prospective Observational Study from Vietnam

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Фев. 28, 2024

Abstract Multisystemic inflammatory in children (MIS-C) might manifest a broad spectrum of clinical scenarios, ranging from mild features to multi-organ dysfunction and mortality. However, this novel entity has heterogenicity data regarding prognostic factors associated with severe outcomes. The present study aimed identify independent predictors for severity by using multivariate regression models. A total 391 patients (255 boys 136 girls) were admitted Vietnam National Children’s Hospital January 2022 June 2023. median age was 85 (range: 2–188) months, only 12 (3.1%) had comorbidities. 161 (31.5%) required PICU admission, the LOS 4 (2–7) days. We observed related including CRP \(\ge\)50 (mg/L) (OR = 2.52, 95%CI;1.39–4.56, p 0.002), albumin \(\le\)30 (g/L) 3.18, 95%CI;1.63–6.02, 0.001), absolute lymphocyte count \(\le\)2 (×10 9 /L) 2.18, 95%CI;1.29–3.71, 0.004), ferritin ≥300 (ng/mL) 2.35, 95%CI;1.38–4.01), LVEF < 60 (%) 2.48, 95%CI;1.28–4.78, 0.007). Shock developed 140 (35.8%) patients, especially those decreased 95%CI;1.10–5.61, 0.029), 2.53, 95%CI;1.22–5.24, 0.013), or <60 2.24, 95%CI;1.12–4.51, 0.022). In conclusion, our emphasized that count, serum albumin, CRP, MIS-C severity, which further well-designed investigations on validation. As is new courses may progress aggressively, identification high-risk optimizes clinicians' follow-up management improve disease

Язык: Английский

Seroprevalence of SARS-CoV-2 infection in pediatric patients in a tertiary care hospital setting

PLoS ONE, Год журнала: 2024, Номер 19(9), С. e0310860 - e0310860

Опубликована: Сен. 24, 2024

Globally, cases of children’s coronavirus disease 2019 (COVID-19) have been reported since the pandemic started. Most children an asymptomatic or mild infection. Therefore, incidence rate COVID-19 in might underestimated. This study aimed to determine (1) seroprevalence (and seroconversion rates) COVID-19, including associated risk factors, pediatric patients visiting hospitals; and (2) immunological responses COVID-19. was a prospective, cross-sectional study. Patients aged 0–18 years who visited hospital from September 2020 February 2022 were included. Demographic, clinical, laboratory data reviewed. A total 1,443 enrolled. Of these, 323 (22.6%) had history In pre-Delta period, increased 4.1% 70.6% all included 0.5% 10% without known compared with Delta-Omicron period. The 6.8% (19 per 100 person-years) Risk factors for seropositivity respiratory symptoms, being outpatient department setting, infection during Exposure household members confirmed factor seroconversion. Infection period testing conducted >2 weeks after onset symptoms spike immunoglobulin (Ig) M nucleocapsid IgG, respectively. High IgG levels pneumonia Pediatric exposed should be tested Nucleocapsid can used as surrogate marker identify may experienced screening tool outbreak, regardless vaccination status.

Язык: Английский