Blowflies are potential vector for avian influenza virus at enzootic area in Japan

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 4, 2024

Abstract High pathogenicity avian influenza (HPAI) poses a significant threat to both domestic and wild birds globally. The virus, known for environmental contamination subsequent oral infection in birds, necessitates careful consideration of alternative introduction routes during HPAI outbreaks. This study focuses on blowflies (genus Calliphora ), particular nigribarbis , attracted decaying animals feces, which migrate lowland areas Japan from northern or mountainous regions early winter, coinciding with season. Our investigation aims delineate the role as vectors by conducting virus prevalence survey bird HPAI-enzootic area. In December 2022, 648 were collected. Influenza RT-PCR testing identified 14 virus-positive samples (2.2% prevalence), highest occurrence observed near crane colony (14.9%). Subtyping revealed presence H5N1 HxN1 some samples. Subsequent collections 2023 one specimen 608 collected flies total, underscoring potential involvement transmission. observations suggest C. may acquire deceased directly fecal materials infected highlighting need add target vector control.

Язык: Английский

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The Alarming Situation of Highly Pathogenic Avian Influenza Viruses in 2019–2023

Global Medical Genetics, Год журнала: 2024, Номер 11(03), С. 200 - 213

Опубликована: Июнь 28, 2024

Abstract Avian influenza viruses (AIVs) have the potential to cause severe illness in wild birds, domestic poultry, and humans. The ongoing circulation of highly pathogenic avian (HPAIVs) has presented significant challenges global poultry industry public health recent years. This study aimed elucidate HPAIVs during 2019 2023. Specifically, we assess alarming spread continuous evolution HPAIVs. Moreover, discuss their transmission prevention strategies provide valuable references for future control measures against AIVs.

Язык: Английский

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Prediction of influenza outbreaks in Fuzhou, China: comparative analysis of forecasting models

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Май 25, 2024

Influenza is a highly contagious respiratory disease that presents significant challenge to public health globally. Therefore, effective influenza prediction and prevention are crucial for the timely allocation of resources, development vaccine strategies, implementation targeted interventions.

Язык: Английский

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Immunization with a novel RNA replicon vaccine confers long-lasting protection against H5N1 avian influenza virus in 24 bird species

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Abstract Highly pathogenic avian influenza viruses (HPAIV) of subtype H5N1 (clade 2.3.4.4b) have spread worldwide and caused the death hundreds millions wild birds domestic poultry. Moreover, spill over HPAIV from infected to more than 50 different mammalian species including humans has been recorded. While, licensed vaccines for protection or are not yet available, a few candidate being trialled. Here, we report on experimental vaccination chickens captive using propagation-defective vesicular stomatitis virus (VSV), in which essential envelope glycoprotein (G) protein gene was replaced by modified hemagglutinin derived clade 2.3.4.4b isolated 2022 animal park Bern, Switzerland. VSVΔG(H5 mb ) produced helper cells providing VSV G trans . Specific pathogen-free (SPF) that were immunized twice via intramuscular route with adjuvant-free replicon particles induced high levels virus-neutralizing serum antibodies fully protected against lethal infection 2.3.4.4b). Notably, animals did shed challenge respiratory gastrointestinal tract, suggesting herd immunity can be achieved. The same vaccine used immunize total 317 at Bern Animal Park Zoo Basel, representing 24 species. No vaccine-associated side effects observed. Birds without previous contact H5Nx very H5-specific neutralizing antibody titers following second immunization, while showing prior vaccination, already developed neutralising after single immunization. One year most still showed significant titers, indicating is able induce long-lasting protective immune response. Our results indicate an extraordinary safe highly efficacious stop replication various

Язык: Английский

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Molecular characterization and genetic analysis of highly pathogenic H5N1 clade 2.3.4.4b in seagulls from Dukan Lake, Iraq

Virus Genes, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

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New Castle Disease ( Orthoavulavirus avian Orthoavulavirus )

Опубликована: Фев. 28, 2025

Язык: Английский

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An overview of Avian Influenza in Colombia: A One Health Perspective on Surveillance, Intervention, and Policy Integration

Revista Colombiana de Ciencias Pecuarias, Год журнала: 2025, Номер 38(4)

Опубликована: Янв. 1, 2025

Avian influenza (AI) remains a significant global health issue, threatening animal and human populations. While only type A viruses (IAV) are known to infect birds naturally, various combinations of IAV subtypes have been discovered in avian species. This paper consolidates existing research offer comprehensive view the flu situation Colombia. It emphasizes significance embracing One Health approach recognizes interconnected nature human, animal, environmental health. Through enhanced collaboration among veterinary, medical, ecological sectors, manuscript advocates for proactive strategy monitor, mitigate, respond AI outbreaks. document also highlights role migratory potentially spreading across borders, underscoring necessity international cooperation interdisciplinary efforts monitor bird migration patterns, strengthen surveillance measures, minimize transmission risks. The review identifies potential hotspots vulnerable regions susceptible highly pathogenic outbreaks based on specific cases within Insights gathered from this analysis can guide targeted interventions, including early detection systems, vaccination drives, community engagement initiatives. Ultimately, work importance integrating considerations into public policies. By principles, policymakers better anticipate mitigate impact outbreaks, safeguarding both offers valuable insights multifaceted challenges Colombia contributes discourse strategies.

Язык: Английский

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Advances in Virus Biorecognition and Detection Techniques for the Surveillance and Prevention of Infectious Diseases

Biosensors, Год журнала: 2025, Номер 15(3), С. 198 - 198

Опубликована: Март 20, 2025

Viral infectious diseases pose a serious threat to global public health due their high transmissibility, rapid mutation rates, and limited treatment options. Recent outbreaks of such as plague, monkeypox, avian influenza, coronavirus disease 2019 (COVID-19) have underscored the urgent need for efficient diagnostic surveillance technologies. Focusing on viral that seriously threaten human health, this review summarizes analyzes detection techniques from perspective combining prevention advice, discusses applications in improving sensitivity specificity. One major innovations is systematic integration advanced biorecognition technologies, bionanosensors, test strips, microfluidic platforms, along with exploration artificial intelligence virus detection. These technologies address limitations traditional methods enable real-time monitoring early warning outbreaks. By analyzing application these pathogens, new insights are provided development next-generation tools emerging re-emerging threats. In addition, we analyze current progress developed vaccines, vaccine research provide ideas future control development, call attention

Язык: Английский

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Hopf bifurcation and optimal control studies for avian-influenza virus with multi-delay model

Advances in Continuous and Discrete Models, Год журнала: 2025, Номер 2025(1)

Опубликована: Март 28, 2025

Язык: Английский

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A LEAP Forward in Wildlife Conservation: A Standardized Framework to Determine Mortality Causes in Large GPS‐Tagged Birds

Ecology and Evolution, Год журнала: 2025, Номер 15(4)

Опубликована: Март 27, 2025

ABSTRACT Anthropogenic activities threaten many wildlife populations by increasing mortality rates, making it crucial to identify the locations and causes of inform conservation actions. Technological advancements, such as GPS satellite tracking, enable precise recording movements. High‐resolution data from devices can facilitate rapid carcass recovery provide insights into tagged individuals. Obtaining required information determine these is complex, standardized approaches overcome limitations. In this study, we introduce LIFE EUROKITE Assessment Protocol (LEAP), a framework for determining timing, locations, in GPS‐tagged birds. LEAP multifaceted approach that integrates: (1) tracking data, (2) evidence location (site investigation), (3) necropsy results derive cause corresponding certainty score. We supplement detailed description with case studies assessing its effectiveness. Using 329 deceased red kites ( Milvus milvus ) compared conditions carcasses processed using 145 opportunistically collected raptor carcasses. also show improves condition therefore allows higher quality results. Additionally, assessed how availability among sources (tracking, site investigation necropsy) influences assessments. Applying all provided highest assessments 64% cases. Some 35% cases were high without necropsy, instead drawing only investigations. Predation related was less prevalent (11%) when relying on (36%), while poisoning showed opposite trend. Furthermore, guidelines empirical examples Our ensures best use available regarding events birds advances research valuable tool conservationists managers.

Язык: Английский

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