Applied Sciences,
Год журнала:
2024,
Номер
14(23), С. 11405 - 11405
Опубликована: Дек. 7, 2024
This
study
aims
to
evaluate
the
potential
benefits
and
challenges
of
integrating
oral
microbiome
research
into
clinical
management
potentially
malignant
disorders
(OPMD)
squamous
cell
carcinoma
(OSCC).
The
has
gained
significant
attention
for
its
role
in
pathogenesis
progression
these
conditions,
with
emerging
evidence
suggesting
value
as
a
diagnostic
prognostic
tool.
By
critically
analyzing
current
methodological
considerations,
this
manuscript
examines
whether
analysis
biopsy
samples
can
aid
early
detection,
prognosis,
OPMD
OSCC.
complexity
dynamic
nature
require
multifaceted
approach
fully
understand
utility.
Based
on
review,
we
conclude
that
studying
context
holds
promise
but
also
faces
notable
challenges,
including
variability
need
standardization.
Ultimately,
addresses
question,
“Should
such
be
undertaken,
given
intricate
interactions
various
factors
inherent
obstacles
involved?”,
emphasizes
importance
further
optimize
applications
improve
patient
outcomes.
The
scientific
literature
dealing
with
alcohol
and
alcoholic
beverages
revealed
that
these
drinks
possess
an
adverse
impact
on
periodontal
tissues.
Additionally,
other
principal
risk
factors
include
tobacco,
smoking,
poor
oral
hygiene,
etc.
It
has
been
observed
among
chronic
alcoholics,
there
are
further
issues,
such
as
mental,
social,
physical
effects,
promote
alcoholism.
These
people
may
have
weak
immunity
for
defense
against
pathogenic
organisms
bacteria.
Thus,
chances
of
gingival
bleeding,
swollen
gums,
bad
breath,
increased
bone
loss
there.
Different
in
the
market
cause
less
salivation;
contain
sugars
acid
production
cavity
by
pathogens
demineralize
enamel
damage
gum
teeth.
This
consumption
can
progress
into
different
types
disorders,
including
cancer,
halitosis,
caries,
is
also
associated
tobacco
smoking.
Chronic
alteration
microbiome
increase
pathogens,
which
lead
to
disease
environment
inflammation
created
body
due
malnutrition,
diminished
immunity,
altered
liver
condition,
brain
damage,
gut
microbiota
alteration.
Heavily
colored
produce
staining
teeth
and,
saliva,
toxic
effects
periodontium.
Over-dependency
leads
necrotizing
lesions
gingivitis,
periodontitis,
stomatitis.
pathological
impairments
instigate
severe
structures.
Therefore,
proper
counseling
attending
dental
surgeon
related
health
professionals
urgently
required
patient
basis
individual
case
needs
go
away
from
regular
heavy
alcohol.
Frontiers in Cell and Developmental Biology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 13, 2025
The
advancement
of
high-throughput
sequencing
technology
in
recent
decades
has
led
to
a
greater
understanding
the
components
oral
microbiota,
providing
solid
foundation
for
extensive
research
this
field.
microbiota
plays
an
important
role
individual’s
overall
health.
It
been
shown
be
significantly
correlated
with
chronic
human
diseases,
including
diabetes,
rheumatoid
arthritis,
cardiovascular
disease,
periodontal
and
Alzheimer’s
disease.
Furthermore,
tumor
occurrence
development
are
closely
related
microbiome.
Specific
bacteria,
such
as
Fusobacterium
nucleatum
(
F.
),
Porphyromonas
gingivalis
P.
Streptococcus
,
Streptomyces
Prevotella
Fibrophagy
gingivalis,
play
critical
roles
cancer
development.
various
oncogenic
mechanisms,
bacterial
inflammation,
immunological
suppression,
growth
mediated
by
toxins,
antiapoptotic
activity,
carcinogenic
effects.
This
paper
reviews
progression
systematically
elucidates
molecular
mechanisms
which
dysbiosis
influences
tumorigenesis
progression.
information
can
provide
theoretical
basis
exploring
treatment
strategies
offer
new
insights
prevention.
Clinics and Practice,
Год журнала:
2025,
Номер
15(4), С. 80 - 80
Опубликована: Апрель 11, 2025
Background/Objectives:
The
diversity
of
the
oral
microbiota
exerts
its
effects
in
maintaining
dental
and
overall
health.
unique
genetic
profile
each
individual
influences
composition
microbiota,
determining
susceptibility
to
certain
diseases.
aim
is
observe
role
by
highlighting
pathogenic
mechanisms
involved
dysbiosis
identify
determinism’s
influence
balance.
Methods:
This
study
was
designed
as
a
narrative
review
utilizing
some
principles
guidelines
systematic
increase
methodological
rigor.
We
examined
121
articles
such
reviews,
meta-analyses,
editorials,
observational
studies,
which
met
inclusion
exclusion
criteria.
criteria
for
studies
were
follows:
(1)
that
evaluated
impact
or/and
systemic
diseases;
(2)
observed
microbiota;
(3)
interaction
with
immune
system
(4);
implications
microbiota.
Results:
Host
genes
regulate
inflammatory
immunological
reactions
play
microbiological
explains
increased
resistance
diseases,
including
gingivitis
or
periodontitis.
Also,
are
reflected
not
only
locally,
but
also
generally,
being
associated
various
conditions.
Conclusions:
Understanding
determinants
may
help
create
individualized
therapies
preventing
managing
disorders.
A
healthy
lifestyle
adequate
hygiene
can
facilitate
diverse
balanced
microbiome,
crucial
Plants,
Год журнала:
2024,
Номер
13(15), С. 2148 - 2148
Опубликована: Авг. 2, 2024
Few
researches
have
explored
the
production
of
pharmaceuticals
from
aquatic
plants.
Therefore,
this
study
explored,
for
first
time,
phytochemical
composition
and
bioactivities
ten
Aquatic
plant
shoots
various
Nile
River
canals
were
collected,
dried,
ground
aqueous
extract
preparation.
Phytochemical
antioxidant
capacity
assessed
using
DPPH
assays.
Extracts
tested
antiparasitic,
antibacterial,
anti-biofilm,
anticancer
activities
through
standard
in
vitro
assays,
measuring
IC50
values,
evaluating
mechanisms
action,
including
cell
viability
high-content
screening
The
results
showed
that
plants
rich
pharmaceutical
compounds.
these
extracts
exceeded
vitamin
C.
promising
antiparasitic
activity
against
pathogens
like
Opisthorchis
viverrini
Plasmodium
falciparum,
with
values
between
0.7
2.5
µg/mL.
They
also
demonstrated
low
MICs
pathogenic
bacteria,
causing
DNA
damage,
increased
plasma
membrane
permeability,
90%
biofilm
inhibition.
In
terms
activity,
effective
a
panel
cancer
lines,
Ludwigia
stolonifera
exhibiting
highest
efficacy.
Its
ranged
0.5
µg/mL
pancreatic,
esophageal,
colon
cells
to
1.5
gastric
cells.
Overall,
all
below
6
µg/mL,
showing
significant
apoptotic
nuclear
intensity,
mitochondrial
cytochrome
c
release,
outperforming
doxorubicin.
This
highlights
potential
as
sources
new,
safe,
drugs
strong
properties.
PLoS ONE,
Год журнала:
2024,
Номер
19(10), С. e0311233 - e0311233
Опубликована: Окт. 22, 2024
Colorectal
cancer
(CRC)
is
influenced
by
perturbations
in
the
colonic
microbiota,
characterized
an
imbalance
favoring
pathogenic
bacteria
over
beneficial
ones.
This
dysbiosis
contributes
to
CRC
initiation
and
progression
through
mechanisms
such
as
carcinogenic
metabolite
production,
inflammation
induction,
DNA
damage,
oncogenic
signaling
activation.
Understanding
role
of
external
factors
shaping
microbiota
crucial
for
mitigating
progression.
study
aims
elucidate
gut
microbiome’s
analyzing
paired
tumor
mucosal
tissue
samples
obtained
from
colon
walls
17
patients.
Through
sequencing
V3-V4
region
16S
rRNA
gene,
we
microbiome
assessed
its
association
with
clinical
variables.
Our
findings
revealed
a
significant
reduction
alpha
diversity
within
compared
biopsy
samples,
indicating
less
diverse
microbial
environment
microenvironment.
While
both
tissues
exhibited
dominance
similar
bacterial
phyla,
their
relative
abundances
varied,
suggesting
potential
colon-specific
effects.
Fusobacteriota
enrichment,
notably
right
colon,
may
be
linked
MLH1
deficiency.
Taxonomy
analysis
identified
genera,
some
primarily
associated
wall
others
unique
this
region.
Conversely,
several
genera
were
exclusively
expressed
tissue.
Functional
biomarker
three
key
genes
differential
abundance
between
microenvironment
tissue,
distinct
metabolic
activities.
abundance:
K11076
(putrescine
transport
system)
K10535
(nitrification)
enriched
microenvironment,
while
K11329
(SasA-RpaAB
circadian
timing
mediator)
dominated
Metabolic
pathway
seven
pathways
microbiome.
Collectively,
these
highlight
alterations
strongly
suggest
that
long-term
profoundly
impacts
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(11), С. 12641 - 12657
Опубликована: Ноя. 7, 2024
The
oral
microbiome,
comprising
bacteria,
fungi,
viruses,
and
protozoa,
is
essential
for
maintaining
both
systemic
health.
This
complex
ecosystem
includes
over
700
bacterial
species,
such
as
