Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Июль 17, 2024
In some patients, persistent gastrointestinal symptoms like abdominal pain, nausea, and diarrhea occur as part of long COVID-19 syndrome following acute respiratory caused by SARS-CoV-2. However, the characteristics immune cells in tract patients their association with these remain unclear.
Язык: Английский
Clinical Therapeutics, Год журнала: 2025, Номер unknown
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 153, С. 114521 - 114521
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0
World of Medicine and Biology, Год журнала: 2025, Номер 21(91), С. 212 - 212
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(3), С. 165 - 165
Опубликована: Фев. 28, 2025
The TRAF family of molecules are intracellular signaling adaptors that regulate various pathways. These pathways not only mediated by the TNFR superfamily and Toll-like receptor/IL-1 receptor but also unconventional cytokine receptors like IL-6 IL-17 receptors. Overactive immune responses caused following activation these frequently result in inflammatory autoimmune diseases such as rheumatoid arthritis, bowel disease, psoriasis, autoinflammatory syndromes. Therefore, it is crucial to comprehend processes controlled TRAFs, which have a significant influence on determination cell fate (life or death) functioning, specialization, endurance cells innate adaptive systems. Our data indicate dysregulation cellular expression and/or TRAFs leads excessive production pro-inflammatory cytokines, hence promoting abnormal cells. objective our investigation was function SARS-CoV-2 infection both prior during vaccination. results demonstrate clear inactivation TRAF5 TRAF6 genes when occurs after immunization, contrast without This can bolster belief immunization essential while demonstrating involvement pathogenesis SARS-CoV-2.
Язык: Английский
Процитировано
0
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Год журнала: 2025, Номер 21(2), С. 112 - 120
Опубликована: Апрель 1, 2025
Background. Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has led to widespread illness and global health challenges. While phase of infection been extensively studied, long-term effects, particularly in individuals who have recovered, remain unclear. Post-acute complications SARS-CoV-2 involves prolonged symptoms systemic disorders, including persistent inflammation, endothelial dysfunction, immune dysregulation, which often last for months. Among key factors contributing these conditions, there are pro-inflammatory cytokines, growth involved angiogenesis, hypoxia-inducible stress-related proteins, play a significant role tissue repair response modulation. The research aimed evaluate degree determine levels pro-angiogenic factors, сellular hypoxia marker HIF-1α, heat shock such as HSP60 HSP70, plasma healthy donors recovered from COVID-19, with particular focus on relationship between biomarkers anti-SARS-CoV-2 IgG titers. Materials methods. This ages 25 45 years, had COVID-19 at least 3 6 months prior beginning study. All patients were divided into groups based their inflammatory TNF-α, transcription factor NF-κB, angiogenic VEGF, PDGF FGF-2, hypoxic proteins measured enzyme-linked immunosorbent assay. Group differences analyzed using ANOVA Tukey’s test or Kruskal-Wallis Dunn’s test, presenting results median interquartile range, significance p ≤ 0.05. Results. study found parameters among donor varying There was an increase markers, TNF-α higher PDGF, FGF-2 showed distinct patterns, VEGF generally reduced, except group titers 95 ± 5 125 10 Index (S/C), where they significantly increased. notably 175 (S/C). HIF-1α also increased 75 (S/C) compared those without IgG. In contrast, HSP70 reduced all reference group, could indicate possible abnormalities mechanisms stress after COVID-19. Conclusions. Our suggest that activation, angiogenesis-related pathways crucial pathogenesis post-COVID-19 complications, underscoring need therapeutic strategies address chronic impaired recovery.
Язык: Английский
Процитировано
0
Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12
Опубликована: Июль 17, 2024
In some patients, persistent gastrointestinal symptoms like abdominal pain, nausea, and diarrhea occur as part of long COVID-19 syndrome following acute respiratory caused by SARS-CoV-2. However, the characteristics immune cells in tract patients their association with these remain unclear.
Язык: Английский
Процитировано
1