Mitochondrial Dysfunction in Neurodegenerative Diseases: Exploring Therapeutic Approaches for Parkinson's Disease

Indus journal of bioscience research., Год журнала: 2025, Номер 3(2), С. 438 - 451

Опубликована: Март 3, 2025

Parkinson ’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and accumulation misfolded α-synuclein protein aggregates. A central aspect PD pathophysiology mitochondrial dysfunction resulting oxidative stress, both which contribute to neuronal degeneration progression. total 121 patients were included in sample, selected using snowball sampling techniques. Data collected through structured interviews medical records, ensuring inclusion demographic information, duration, stage, current treatment regimens. The analysis revealed that majority participants male (53.7%), with highest age group falling 60-69 years range (33.1%). duration varied, most (45.5%) being diagnosed within last 5 years. study also explored comorbidities, hypertension (41.3%) common, followed diabetes (24.8%) cardiovascular (16.5%). This aimed explore relationship between dysfunction, clinical outcomes patients, as well examine potential influence stage on choices. from major hospitals Pakistan participated study, data, including age, gender, disease, collected. Statistical analysis, correlation, multiple regression, Chi-Square tests, significant correlations severity PD. Oxidative stress exerted stronger was identified contributor regression analysis. No association found medication type. These results emphasize importance targeting stress. Future research should develop therapies restore function reduce slow

Язык: Английский

Critical perspectives on advancing antibiotic resistant gene (ARG) detection technologies in aquatic ecosystems

The Science of The Total Environment, Год журнала: 2024, Номер 957, С. 177775 - 177775

Опубликована: Ноя. 30, 2024

Язык: Английский