The forgotten link: how the oral microbiome shapes childhood growth and development DOI Creative Commons
Raymond R. Tjandrawinata, Nurlinah Amalia, Yosi Yohanes Putra Tandi

и другие.

Frontiers in Oral Health, Год журнала: 2025, Номер 6

Опубликована: Фев. 7, 2025

Childhood stunting, defined as impaired linear growth and development, remains a significant global health challenge with long-term consequences on cognitive physical well-being. Emerging evidence highlights the pivotal role of oral microbiome-a dynamic microbial ecosystem-in influencing nutritional status, immune response, overall systemic health. This review explores intricate interplay between microbiome emphasizing mechanisms such dysbiosis, its impact nutrient absorption, modulation. Disruptions in can lead to malabsorption inflammation, further exacerbating impairments children. Furthermore, potential for microbiome-targeted diagnostics interventions, including probiotics prebiotics, offers novel strategies address stunting. A deeper understanding these interactions may inform innovative diagnostic tools therapeutic interventions aimed at mitigating stunting through Integrating research into prevention efforts could provide valuable insights public improve child particularly resource-limited settings. Future should focus elucidating molecular pathways linking developing personalized that optimize early life.

Язык: Английский

The forgotten link: how the oral microbiome shapes childhood growth and development DOI Creative Commons
Raymond R. Tjandrawinata, Nurlinah Amalia, Yosi Yohanes Putra Tandi

и другие.

Frontiers in Oral Health, Год журнала: 2025, Номер 6

Опубликована: Фев. 7, 2025

Childhood stunting, defined as impaired linear growth and development, remains a significant global health challenge with long-term consequences on cognitive physical well-being. Emerging evidence highlights the pivotal role of oral microbiome-a dynamic microbial ecosystem-in influencing nutritional status, immune response, overall systemic health. This review explores intricate interplay between microbiome emphasizing mechanisms such dysbiosis, its impact nutrient absorption, modulation. Disruptions in can lead to malabsorption inflammation, further exacerbating impairments children. Furthermore, potential for microbiome-targeted diagnostics interventions, including probiotics prebiotics, offers novel strategies address stunting. A deeper understanding these interactions may inform innovative diagnostic tools therapeutic interventions aimed at mitigating stunting through Integrating research into prevention efforts could provide valuable insights public improve child particularly resource-limited settings. Future should focus elucidating molecular pathways linking developing personalized that optimize early life.

Язык: Английский

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