The Clinical and Laboratory Landscape of COVID-19 During the Initial Period of the Pandemic and at the Beginning of the Omicron Era DOI Creative Commons
Yulia Desheva, Tamara Shvedova, Olga Kopteva

и другие.

Viruses, Год журнала: 2025, Номер 17(4), С. 481 - 481

Опубликована: Март 27, 2025

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underwent significant mutations, resulting in the Omicron variant. Methods: In this study, we analyzed blood samples from 98 patients with disease 19 (COVID-19) hospitalized during initial SARS-CoV-2 wave and onset of 2021. High-resolution melting (HRM) analysis PCR products was used to analyze RNA extracted clinical collected July November 2021 infected SARS-CoV-2. Results: HRM revealed a characteristic deletion N protein virus isolated 2021, associated Elevated levels inflammatory markers interleukin-6 (IL-6) were observed both waves COVID-19. Complement IgG IgM antibodies detected more often second wave. An increase hemagglutinin-inhibiting (HI) against influenza viruses paired specimens moderate severe COVID-19 outbreaks. Conclusions: Patients admitted showed rise markers, suggesting that triggers responses. The rapid formation may indicate faster immune response. Seasonal flu negatively impact course infections.

Язык: Английский

The Clinical and Laboratory Landscape of COVID-19 During the Initial Period of the Pandemic and at the Beginning of the Omicron Era DOI Creative Commons
Yulia Desheva, Tamara Shvedova, Olga Kopteva

и другие.

Viruses, Год журнала: 2025, Номер 17(4), С. 481 - 481

Опубликована: Март 27, 2025

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underwent significant mutations, resulting in the Omicron variant. Methods: In this study, we analyzed blood samples from 98 patients with disease 19 (COVID-19) hospitalized during initial SARS-CoV-2 wave and onset of 2021. High-resolution melting (HRM) analysis PCR products was used to analyze RNA extracted clinical collected July November 2021 infected SARS-CoV-2. Results: HRM revealed a characteristic deletion N protein virus isolated 2021, associated Elevated levels inflammatory markers interleukin-6 (IL-6) were observed both waves COVID-19. Complement IgG IgM antibodies detected more often second wave. An increase hemagglutinin-inhibiting (HI) against influenza viruses paired specimens moderate severe COVID-19 outbreaks. Conclusions: Patients admitted showed rise markers, suggesting that triggers responses. The rapid formation may indicate faster immune response. Seasonal flu negatively impact course infections.

Язык: Английский

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