Bacteriophages as a Potential 360-Degree Pathogen Control Strategy

Microorganisms, Год журнала: 2021, Номер 9(2), С. 261 - 261

Опубликована: Янв. 27, 2021

Bacteriophages are viruses that exclusively kill bacteria and the most ubiquitous organisms on planet. Since their discovery, bacteriophages have been considered an important weapon to fight human animal infections of bacterial origin due specific ability attack associated target bacteria. With discovery antibiotics, phage treatment was progressively abandoned in Western countries. However, recent emergence growing antimicrobial resistance (AMR) interest use therapy has once again grown. Similarly, at environmental level, extensive disinfectants based chemicals, including biocides agriculture, with against themselves, besides having a high impact. Due these issues, applications phages biocontrol purposes become interesting option several fields, farms, food industry, aquaculture wastewater plants. Notably, action is maintained even when multidrug resistant (MDR), rendering this extremely counteracting AMR both for therapeutical decontamination purposes. Based this, interestingly proposed as routine sanitizers hospitals, counteract spread pathogenic MDR persistently contaminate hard surfaces. This review summarizes studies aimed evaluating potential decontaminants, special focus hospital sanitation.

Язык: Английский

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Bacteriophages and Food Production: Biocontrol and Bio-Preservation Options for Food Safety

Antibiotics, Год журнала: 2022, Номер 11(10), С. 1324 - 1324

Опубликована: Сен. 28, 2022

Food safety and sustainable food production is an important part of the Sustainable Development goals aiming to safeguard health wellbeing humans, animals environment. Foodborne illness a major cause morbidity mortality, particularly as global crisis antimicrobial resistance proliferates. In order actively move towards production, it imperative that green biocontrol options are implemented prevent mitigate infectious disease in production. Replacing current chemical pesticides, antimicrobials disinfectants with green, organic such biopesticides step future. Bacteriophages, virus which infect kill bacteria area great potential agents agriculture aquaculture. Lytic bacteriophages offer many advantages over traditional chemical-based solutions control microbiological contamination industry. The innate specificity for target bacterial species, their natural presence environment biocompatibility animal humans means phages practical candidate at all stages from farm-to-fork. Phages have demonstrated efficacy bio-sanitisation bio-preservation against foodborne pathogens, activity biofilm communities also evident. Additionally, long been recognised therapeutics, prophylactically metaphylactically. Further investigation warranted however, overcome limitations formulation stability issues, phage mechanisms transmission virulence factors.

Язык: Английский

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An overview of the use of bacteriophages in the poultry industry: Successes, challenges, and possibilities for overcoming breakdowns

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Март 21, 2023

The primary contaminants in poultry are Salmonella enterica , Campylobacter j ejun i, Escherichia coli, and Staphylococcus aureus . Their pathogenicity together with the widespread of these bacteria, contributes to many economic losses poses a threat public health. With increasing prevalence bacterial pathogens being resistant most conventional antibiotics, scientists have rekindled interest using bacteriophages as antimicrobial agents. Bacteriophage treatments also been investigated an alternative antibiotics industry. Bacteriophages’ high specificity may allow them only target specific pathogen infected animal. However, tailor-made sophisticated cocktail different could broaden their antibacterial activity typical situations multiple clinical strains infections. Bacteriophages not be used terms reducing contamination animals but also, under industrial conditions, they can safe disinfectants reduce on food-contact surfaces or carcasses. Nevertheless, bacteriophage therapies developed sufficiently for use. Problems resistance, safety, specificity, long-term stability must addressed particular. This review highlights benefits, challenges, current limitations applications

Язык: Английский

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Bacteriophages and food safety: An updated overview

Food Science & Nutrition, Год журнала: 2023, Номер 11(7), С. 3621 - 3630

Опубликована: Май 4, 2023

Abstract Despite significant advances in pathogen survival and food cleaning measures, foodborne diseases continue to be the main reason for hospitalization or other fatality globally. Conventional antibacterial techniques including pasteurization, pressurized preparation, radioactivity, as well synthetic antiseptics could indeed decrease bacterial activity nutrition variable levels, despite their serious downsides like an elevated upfront outlay, possibility of accessing malfunctions due one corrosiveness, adverse effect upon those foodstuffs' organoleptic properties maybe nutritional significance. Greatest significantly, these cleansing methods eliminate all contaminants, numerous (often beneficial) bacteria found naturally food. A huge amount scientific publication that discussed application virus bioremediation treat a multitude pathogenic meals spanning between prepared raw fresh fruit vegetables although since initial idea through using retroviruses on meals. Furthermore, quantity widely viable bacteriophage‐containing medicines licensed use health safety purposes has continuously expanded. Bacteriophage bio‐control, leafy ordinary technique employs lytic bacteriophages extracted from atmosphere selectively target remove meaningfully stages meals, is potential remedy solves some difficulties. It been suggested applying unique method avoiding development vegetables. Because selectivity, security, stability, use, are desirable. Phages have utilized post‐harvest activities, either alone combination with antimicrobial drugs, they effective, strain‐specific, informal split manipulate. In this review ensure safety, it may spontaneous treatment thread pollution picked fruits vegetables, dairy, convenience foods.

Язык: Английский

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Prophage-DB: a comprehensive database to explore diversity, distribution, and ecology of prophages

Environmental Microbiome, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 13, 2025

Abstract Background Viruses that infect prokaryotes (phages) constitute the most abundant group of biological agents, playing pivotal roles in microbial systems. They are known to impact community dynamics, ecology, and evolution. Efforts document diversity, host range, infection effects bacteriophage on cell metabolism extremely underexplored. Phages classified as virulent or temperate based their life cycles. Temperate phages adopt lysogenic mode infection, where genome integrates into forming a prophage. Prophages enable viral replication without lysis, often contribute novel beneficial traits genome. Current phage research predominantly focuses lytic phages, leaving significant gap knowledge regarding prophages, including biology, ecological roles. Results Here we develop describe Prophage-DB, database proteins, associated metadata will serve resource for genomics ecology. To create database, identified characterized prophages from genomes three largest publicly available databases. We applied several state-of-the-art tools our pipeline annotate these viruses, cluster them, taxonomically classify detect respective auxiliary metabolic genes. In total, identify characterize over 350,000 35,000 Our prophage is highly representative statistical results contains diverse set archaeal bacterial hosts which show wide environmental distribution. Conclusion Given particularly overlooked merit increased attention due vital implications microbiomes hosts, created Prophage-DB advance understanding through comprehensive characterization genomes. propose valuable advancing research, offering insights taxonomy, relationships, genes,

Язык: Английский

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The Role of Active Packaging in the Defense Against Foodborne Pathogens with Particular Attention to Bacteriophages

Microorganisms, Год журнала: 2025, Номер 13(2), С. 401 - 401

Опубликована: Фев. 12, 2025

The increasing demand for food safety and the need to combat emerging foodborne pathogens have driven development of innovative packaging solutions. Active packaging, particularly those incorporating antimicrobial agents, has emerged as a promising approach enhance preservation safety. Among these bacteriophages (phages) gained significant attention due their specificity, efficacy, natural origin. This manuscript explores role active in protecting against pathogens, with particular focus on bacteriophages. review overviews recent advances antimicrobials followed by detailed discussion bacteriophages, including classification, mode action, multidisciplinary applications, use agents packaging. also highlights commercially available bacteriophage-based products addresses challenges limitations associated integration into materials. Despite potential, issues such stability, regulatory hurdles, consumer acceptance remain critical considerations. In conclusion, represent tool enhancing safety, but further research innovation are needed overcome existing barriers fully realize potential industry.

Язык: Английский

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Oral bacteriophages and their potential as adjunctive treatments for periodontitis: a narrative review

Journal of Oral Microbiology, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 25, 2025

Background There is no specific cure for periodontitis and treatment symptomatic, primarily by physical removal of the subgingival plaque biofilm. Current non-surgical periodontal therapy becomes less effective as pocket depth increases such new adjunctive treatments are required. The development antibiotic resistance has driven a recent resurgence interest in bacteriophage therapy.

Язык: Английский

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Effectiveness of Phage-Based Inhibition of Listeria monocytogenes in Food Products and Food Processing Environments

Microorganisms, Год журнала: 2020, Номер 8(11), С. 1764 - 1764

Опубликована: Ноя. 10, 2020

Providing safe products and compliance of legal requirements is still a great challenge for food manufacturers regarding microbiological safety, especially in the context Listeria monocytogenes contamination. L. human pathogen, which, due to ability survival proliferation preservation conditions such as high salinity, acidity refrigeration temperatures, significant threat industry. Novel methods elimination bacterial pathogen processing environments are required. Among emerging technologies, one very promising solutions using bacteriophages natural control agents. This review focus on major aspects phage-based inhibition safety. We describe an overview foods technological factors influencing efficacy phage use biocontrol monocytogenes. The most noteworthy matrix properties, concentration stability, time application product storage temperature. combined methods, immobilization (active packing), resistance phages legislation antilisterial bacteriophage industry also discussed.

Язык: Английский

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Bacteriophages in water pollution control: Advantages and limitations

Frontiers of Environmental Science & Engineering, Год журнала: 2020, Номер 15(5)

Опубликована: Дек. 4, 2020

Язык: Английский

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Bacteriophages and the One Health Approach to Combat Multidrug Resistance: Is This the Way?

Antibiotics, Год журнала: 2020, Номер 9(7), С. 414 - 414

Опубликована: Июль 16, 2020

Antimicrobial resistance necessitates action to reduce and eliminate infectious disease, ensure animal human health, combat emerging diseases. Species such as Acinetobacter baumanniii, vancomycin resistant Enterococcus, methicillin Staphylococcus aureus, Pseudomonas aeruginosa, well other WHO priority pathogens, are becoming extremely difficult treat. In 2017, the EU adopted “One Health” approach antibiotic in medicine prevent transmission of zoonotic disease. As current therapeutic agents become increasingly inadequate, there is a dire need establish novel methods treatment under this One Health Framework. Bacteriophages (phages), viruses infecting bacterial species, demonstrate clear antimicrobial activity against an array with high levels specificity potency. play key roles evolution essential components all ecosystems, including microbiome. Factors their specificity, potency, biocompatibility, bactericidal make them desirable options therapeutics. Issues remain, however, relating large-scale production, formulation, stability, resistance, limiting implementation globally. Phages used therapy must be virulent, purified, characterized before administration. Clinical studies warranted assess vivo pharmacokinetics pharmacodynamic characteristics phages fully potential.

Язык: Английский

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