Journal of Microencapsulation,
Год журнала:
2024,
Номер
41(8), С. 818 - 831
Опубликована: Ноя. 7, 2024
The
dermal
route
is
commonly
used
to
deliver
the
drugs
at
targeted
site
and
achieve
maximum
therapeutic
efficacy.
stratum
corneum,
uppermost
layer
of
skin,
presents
a
significant
diffusional
barrier
for
most
drugs.
Various
nanoformulations
face
challenges
such
as
limited
drug
absorption
inadequate
retention
site,
frequently
hindering
Researchers
are
increasingly
exploring
innovative
strategies
that
leverage
nanotechnology
specialized
carriers
address
these
enhance
outcomes
medications.
A
novel
delivery
system,
bilosomes,
has
been
designed
potential
vesicular
carrier
system
route.
Bilosomes
colloidal,
lipid-based
vesicles
stabilized
with
bile
salts,
offering
greater
stability
during
storage
transportation.
lipid
bilayer
bilosomes
imparts
ultra-flexibility,
facilitating
penetration
through
corneum.
This
review
explores
use
in
formulations
treating
diverse
diseases,
their
developmental
techniques,
characterization,
it
sheds
light
on
advantages
over
traditional
nanocarriers.
Drug Development and Industrial Pharmacy,
Год журнала:
2023,
Номер
unknown, С. 1 - 12
Опубликована: Сен. 19, 2023
Breast
cancer
affects
women
globally,
regardless
of
age
or
location.
On
the
other
hand,
Tamoxifen
(TXN),
a
class
II
biopharmaceutical
drug
is
acting
as
prophylactic/treating
agent
for
at
risk
and/or
with
hormone
receptor-positive
breast
cancer.
However,
its
oral
administration
has
life-threatening
side
effects,
which
have
led
researchers
to
investigate
alternative
delivery
methods.
One
such
method
transdermal
utilizing
bile
salts
penetration
enhancers,
aka
Bilosomes.Bilosomes
formulations
were
optimized
statistically
outcome
vesicle
shape,
size,
and
entrapment
efficiency
using
two
types
bile,
i.e.
sodium
taurocholate
cholate.
These
bilosomes
then
loaded
into
HPMC
base
gel
further
characterized
their
morphology,
content,
pH,
viscosity,
spreadability
eventually
ex-vivo
skin
deposition
studies.Findings
showed
that
cholate
superiority
enhancer
over
in
terms
morphological
characterizes,
zeta
potential,
cumulative
amounts
tamoxifen
permeated
per
unit
area
(15.13
±
0.71
μg/cm2
6.51
0.6
respectively).
In
fact,
designed
provided
around
9
folds
compared
TXN
non-bilosomal
gel.Bilosomes
gels
could
be
promising
option
locally
delivering
through
skin,
offering
an
encouraging
solution.
Journal of Microencapsulation,
Год журнала:
2024,
Номер
41(8), С. 818 - 831
Опубликована: Ноя. 7, 2024
The
dermal
route
is
commonly
used
to
deliver
the
drugs
at
targeted
site
and
achieve
maximum
therapeutic
efficacy.
stratum
corneum,
uppermost
layer
of
skin,
presents
a
significant
diffusional
barrier
for
most
drugs.
Various
nanoformulations
face
challenges
such
as
limited
drug
absorption
inadequate
retention
site,
frequently
hindering
Researchers
are
increasingly
exploring
innovative
strategies
that
leverage
nanotechnology
specialized
carriers
address
these
enhance
outcomes
medications.
A
novel
delivery
system,
bilosomes,
has
been
designed
potential
vesicular
carrier
system
route.
Bilosomes
colloidal,
lipid-based
vesicles
stabilized
with
bile
salts,
offering
greater
stability
during
storage
transportation.
lipid
bilayer
bilosomes
imparts
ultra-flexibility,
facilitating
penetration
through
corneum.
This
review
explores
use
in
formulations
treating
diverse
diseases,
their
developmental
techniques,
characterization,
it
sheds
light
on
advantages
over
traditional
nanocarriers.
