Sex differences in osteoarthritis prevalence, pain perception, physical function and therapeutics

Osteoarthritis and Cartilage, Год журнала: 2024, Номер 32(9), С. 1045 - 1053

Опубликована: Апрель 6, 2024

Women have a higher prevalence of osteoarthritis (OA) and worse clinical courses than men. However, the underlying factors therapeutic outcomes these sex-specific differences are incompletely researched. This review examines current state knowledge regarding sex in OA prevalence, risk factors, pain severity, functional outcomes, use response to therapeutics.

Язык: Английский

---

Potentially inappropriate prescribing among older adults receiving home health care service: A retrospective study in Saudi Arabia

Home Health Care Management & Practice, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

To address the risks associated with potentially inappropriate prescribing (PIP) in older adults, this study aimed to determine prevalence of PIP home health care patients Taif Health Cluster, Saudi Arabia. Using Beers, STOPP, and START criteria, a retrospective analysis was conducted on 400 adults aged 65 over who received between February October 2023. Results indicated that 38.5% had at least one incident, polypharmacy present 80.6% cases. more prevalent among females those 75 older. Potentially medications (PIMs) were noted cases, while omissions (PIOs) recorded 26.5%. The most frequent cause PIMs lack clear indication, affecting 23.3% total prescriptions. Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor antagonists (AIIRAs) commonly omitted diabetic renal disease. Findings highlight need for regular prescription reviews reduce improve patient outcomes.

Язык: Английский

---

Gender inequalities in prescribing and initiation patterns of guideline-recommended drugs after acute myocardial infarction

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 16, 2025

European guidelines recommend the prescription of certain drugs after acute myocardial infarction (AMI). The existence gender differences in pharmacological treatment an AMI has been described. This study aims to describe and analyse, using real-world data (RWD), whether there are prescribing patterns initiation secondary prevention a first AMI, which factors that explain these differences. A population-based observational RWD was conducted CARhES (CArdiovascular Risk for hEalth Services research) cohort. included subjects who had experienced episode between 2017 2022, survived event, minimum follow-up 180 days. 3,975 were followed days AMI. Women (27.8% population) older more comorbidities. Of main guideline-recommended drugs, antiplatelets, lipid modifying agents beta-blockers, prescribed less often women. Comedications such as rivaroxaban calcium channel blockers likely be proportion initiating similar both genders. Overall, age morbidity burden contributors patterns. Living urban area seemed protective or mitigating factor. There controversial results regarding socioeconomic level. In our population, women older, have greater comorbidities lower status. Despite this, inequalities remains, appear experience therapeutic effort. It is crucial analyse them from intersectional perspective, considering influence multiple axes inequality on health, order develop gender-sensitive strategies with multidisciplinary approach.

Язык: Английский

---

Association of potentially inappropriate medications with frailty and frailty components in community‐dwelling older women in Japan: The Otassha Study

Geriatrics and gerontology international/Geriatrics & gerontology international, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Aim The use of potentially inappropriate medications (PIMs) in older adults can increase the risk drug‐related adverse events. We aimed to examine associations between PIMs, frailty, and each frailty component community‐dwelling women. Methods This cross‐sectional study included participants aged ≥65 years from a prospective cohort Japanese Frailty was classified using version Fried's Criteria, comprising five components. PIMs were identified screening tool for among regular prescription collected participants' notebooks. Multivariable logistic regression models adjusted age comorbidities used association (0, 1, 2, ≥3), component. possible interactions groups (65–74 ≥75 years) investigated. Age‐stratified analyses also performed. Results analyzed 530 women (median [interquartile range], 71 [68, 75] with prevalence 5.5%. Three or more associated weight loss (adjusted odds ratio [95% confidence interval], 3.80 [1.23, 11.80], 2.53 [1.15, 5.39]). In age‐stratified analyses, ≥3 (8.39 [1.79, 48.98]) years, whereas 1 2 (4.52 [1.17, 19.08]) weakness (3.13 [1.22, 7.78]) those 65–74 years. Conclusions Our results may suggest that number PIM prescriptions is components Longitudinal studies are required clarify causality frailty. Geriatr Gerontol Int 2025; ••: ••–•• .

Язык: Английский

---

Gender differences in pre-surgical hip arthroplasty patients

Frontiers in Global Women s Health, Год журнала: 2025, Номер 6

Опубликована: Апрель 22, 2025

Introduction There is growing evidence that gender may influence surgical outcomes, rehabilitation, and overall patient experience in various orthopedic procedures. The main objective of the present study was to explore gender-based differences patients undergoing hip arthroplasty surgery understand better how they might impact preoperative contribute personalized care. Methods A cross-sectional conducted with n = 180 pre-surgical participants ( 84 females, 96 males). All were consecutively admitted for primary at orthopedics traumatology unit Hospital Clínic Barcelona (Spain), between October 1, 2023 July 31, 2024. assessment consisted a socio-demographic form two questionnaires: Anxiety Depression Scale (HADS) 5-level EQ-5D version (EQ-5D-5l). Results Both groups similar percentage males females. Females presented statistically significantly higher levels anxiety than p .050), but no significant appeared depression subscale .382). Regarding quality life, females reported scores on difficulties mobility .037), usual activities .027), perceived pain .004) compared males. Finally, greater associated poor self-perceived health not Conclusions This essential bridge gaps knowledge regarding arthroplasty. Clinically, these results underline importance considering gender-specific factors when planning interventions support improve outcomes well-being.

Язык: Английский

---

Potential drug-drug interactions among geriatric oncology patients: a retrospective study in Saudi Arabia

BMC Geriatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Май 1, 2025

Язык: Английский

---

Sex and gender differences and pharmacovigilance: a knot still to be untied

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Апрель 17, 2024

Citation: Sportiello L and Capuano A (2024) Sex gender differences pharmacovigilance: a knot still to be untied. Front. Pharmacol. 15:1397291. doi: 10.3389/fphar.2024.1397291

Язык: Английский

---

Potentially inappropriate prescriptions and potential prescription omissions in older people living with HIV

HIV Medicine, Год журнала: 2024, Номер 25(5), С. 587 - 599

Опубликована: Янв. 23, 2024

Abstract Objectives This study aimed to determine the prevalence of potentially inappropriate prescriptions (PIPs) and potential prescription omissions (PPOs) in a Spanish cohort people living with HIV (PLWH) aged ≥65 years identify risk factors for presence PIPs PPOs. Methods retrospective cross‐sectional was conducted across 10 public hospitals Autonomous Community Madrid, Spain. Clinical demographic data were cross‐checked against hospital community pharmacy dispensation registries. PPOs assessed using American Geriatrics Society (AGS)/Beers Screening Tool Older Persons' Prescriptions (STOPP)/Screening Alert Doctors Right Treatment (START) criteria. Risk agreement between AGS/Beers STOPP/START criteria statistically analysed. Results included 313 PLWH (median age 72 years), whom 80.5% men. PIP rates 29.4% 44.4% based on STOPP criteria, respectively. The concordance moderate. Benzodiazepines proton pump inhibitors chronic comedications most commonly involved PIPs. observed 61.4% patients. leading insufficient influenza pneumococcal vaccine coverage inadequate bone health‐related treatments. number comedications, female sex, neuropsychiatric disorders, cancer diagnosis PIPs, whereas osteopenia osteoporosis Conclusions A high our older PLWH. These findings emphasize importance comprehensive medication reviews this population reduce use address their specific underserved therapeutic needs.

Язык: Английский

---

Drug Related Problems among Older Inpatients at a Tertiary Care Setting

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(6), С. 1638 - 1638

Опубликована: Март 13, 2024

Background: Older persons are more likely to have multiple chronic diseases, leading the simultaneous use of many medications. This situation results in increased drug-related problems (DRPs), which causes adverse health outcomes. Therefore, we aimed evaluate prevalence and associated risk factors for exposure >1 criterion DRPs among older adults admitted a tertiary care hospital. Methods: We conducted cross-sectional study involving 357 participants aged ≥60 years Ramathibodi Hospital from 1 February 2022 30 November 2022. The were evaluated baseline characteristics, medications classified into two groups, according their DRPs: patients with ≤1 criteria DRPs. Multivariate logistic regression analysis was performed determine independent Results: Overall, 205 (57.4%) experienced Approximately 67.8%, 71.7% 7.6% exposed at least one potentially inappropriate medication (PIM), drug–drug interaction (DDI) drug events (ADE), respectively. most frequently prescribed PIMs proton pump inhibitors (PPIs) (17.3%). Antineoplastics (48.1%) class related ADEs. 37% ADEs current considered preventable After adjustment potential confounders, polypharmacy inhibitors, hypoglycemics, diuretics, psycholeptics, psychoanaleptics cardiac therapy correlated higher > PIMs, DDIs or Conclusions: comprehensive reviews careful prescriptions recommended geriatric population.

Язык: Английский

---

IL24 Expression in Synovial Myofibroblasts: Implications for Female Osteoarthritis Pain through Propensity Score Matching Analysis

Medicina, Год журнала: 2024, Номер 60(5), С. 741 - 741

Опубликована: Апрель 29, 2024

(1)

---