Assessment of polyvinylpyrrolidone vinyl acetate effect on quercetin properties in binary solid dispersion prepared by hot melt extrussion DOI Creative Commons
A. A. Danilova, K. A. Gusev, N. O. Arkhipova

и другие.

Drug development & registration, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Introduction. Flavonoids, despite their pronounced therapeutic benefits, are limitedly used in medicine as active pharmaceutical ingredients (API) owing to a complex of unsatisfactory physicochemical properties. In order study the mentioned problem, we decided use quercetin model compound with extremely low water solubility and dissolution gastrointestinal (GI) tract media. Therefore, main idea appears possibility prospects hot melt extrusion (HME) application for enhancement properties composition solid dispersion system (SDS) based on hydrophilic polymeric carrier (polyvinylpyrrolidone vinyl acetate, PVP/VA). Consequently, there is necessity select effective drug-to-polymer ratio providing better Aim. Assessment PVP/VA effect binary prepared by HME. Materials methods. Quercetin substance purity 98 % was purchased from Molekula Limited, United Kingdom. (copolymer polyvinylpyrrolidone acetate 60 : 40, VIVAPHARM® 64) procured JRS PHARMA (JRS GmbH & Co. KG, Germany). SDS were using micro-conical twin screw compounder HAAKE™ MiniCTW (Thermo Fisher Scientific, The obtained samples analyzed phase-contrast microscopy, FTIR spectroscopy differential scanning calorimetry (DSC). quantitative content determined UV-spectrophotometry. Results discussion. improvement rates comparison pure observed all compositions irrespective ratio. Notably, reduction contribution increased. We found partial or even complete amorphization API formulations 1 5 content, resulting properties, stability solutions increased GI Water relative enhanced 353-fold. At same time, release achieved 40 minutes hydrochloric acid citrate buffer, also 90 minute phosphate buffer. Conclusion. be most promising dosage forms development.

Язык: Английский

Comprehensive Review on Chromatographic Analysis of Flavonoids in Fruits DOI Creative Commons
Ahmet Çetinkaya, Seyda Yayla, Muhammed Mesud HÜRKUL

и другие.

Journal of Chromatography Open, Год журнала: 2025, Номер unknown, С. 100209 - 100209

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Genus Echinophora—Biological Activity, Chemical Composition, and Future Perspectives DOI Creative Commons
Stanislava Ivanova, Stanislav Dyankov, Raina Ardasheva

и другие.

Plants, Год журнала: 2024, Номер 13(12), С. 1599 - 1599

Опубликована: Июнь 8, 2024

Species belonging to the genus Echinophora (Apiaceae) have been used by humanity since ancient times as flavoring agents, preservatives, and medicines for treatment of a broad spectrum conditions, including respiratory, digestive kidney disorders, fungi infections, wounds, gastric ulcers. Phytochemical studies on this botanical mainly investigate essential oil composition reveal species rich source volatile compounds, monoterpenes phenylpropanoids. Among non-volatile secondary metabolites, flavonoids, coumarins, phenolic acids, phytosterols, polyacetylenes identified. Pharmacological revealed extracts oils exhibit different biological properties, antibacterial, antifungal, anticancer, insecticidal, anti-inflammatory, hepatoprotective activities. However, compared other genera, activity chemical diversity are not well studied. In future decades, it is highly likely that small will play an important role in drug discovery development.

Язык: Английский

Процитировано

2
Synergistic Antioxidant Activity in Deep Eutectic Solvents: Extracting and Enhancing Natural Products DOI Creative Commons
Luis Alfonso Jiménez‐Ortega,

Jayanta Kumar-Patra,

Rout George Kerry

и другие.

ACS Food Science & Technology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Many natural products (NPs) exhibit strong antioxidant activity, making them valuable for various applications. In this context, the emergence of deep eutectic solvents (DESs) is expected to help address growing demand innovative, efficient, and more sustainable methods NPs extraction. DESs are designer that provide higher yields enhance activity extracted phytochemicals compared with conventional volatile organic solvents. Antioxidant naturally occurring molecules can also form DESs, either as hydrogen bond donors (HBD) or acceptors (HBA), creating DES (NADES) inherent activity. Thus, containing exert synergistic effects, entire system a promising active ingredient food industry The synergy arises from enhanced solubilization stabilization in through bonding, ionic interactions, van der Waals forces. Collectively, enable effectively neutralize oxidants (such ROS free radicals) regulate their reactions other molecules, achieving up 3-fold increase extracts regular vitro. This Account overviews wide range resources using DESs. activities HBA, HBD, along advantageous coupling extracts, thoroughly discussed. Finally, we envisage future directions potential applications harnessing collective guide advances chemistry.

Язык: Английский

Процитировано

2
Assessment of polyvinylpyrrolidone vinyl acetate effect on quercetin properties in binary solid dispersion prepared by hot melt extrussion DOI Creative Commons
A. A. Danilova, K. A. Gusev, N. O. Arkhipova

и другие.

Drug development & registration, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Introduction. Flavonoids, despite their pronounced therapeutic benefits, are limitedly used in medicine as active pharmaceutical ingredients (API) owing to a complex of unsatisfactory physicochemical properties. In order study the mentioned problem, we decided use quercetin model compound with extremely low water solubility and dissolution gastrointestinal (GI) tract media. Therefore, main idea appears possibility prospects hot melt extrusion (HME) application for enhancement properties composition solid dispersion system (SDS) based on hydrophilic polymeric carrier (polyvinylpyrrolidone vinyl acetate, PVP/VA). Consequently, there is necessity select effective drug-to-polymer ratio providing better Aim. Assessment PVP/VA effect binary prepared by HME. Materials methods. Quercetin substance purity 98 % was purchased from Molekula Limited, United Kingdom. (copolymer polyvinylpyrrolidone acetate 60 : 40, VIVAPHARM® 64) procured JRS PHARMA (JRS GmbH & Co. KG, Germany). SDS were using micro-conical twin screw compounder HAAKE™ MiniCTW (Thermo Fisher Scientific, The obtained samples analyzed phase-contrast microscopy, FTIR spectroscopy differential scanning calorimetry (DSC). quantitative content determined UV-spectrophotometry. Results discussion. improvement rates comparison pure observed all compositions irrespective ratio. Notably, reduction contribution increased. We found partial or even complete amorphization API formulations 1 5 content, resulting properties, stability solutions increased GI Water relative enhanced 353-fold. At same time, release achieved 40 minutes hydrochloric acid citrate buffer, also 90 minute phosphate buffer. Conclusion. be most promising dosage forms development.

Язык: Английский

Процитировано

0