One-step green synthesis of collagen nanoparticles using Ulva fasciata, network pharmacology and functional enrichment analysis in hepatocellular carcinoma treatment

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 139244 - 139244

Опубликована: Янв. 1, 2025

Язык: Английский

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A Comprehensive Review on Mycosynthesis of Nanoparticles, Characteristics, Applications, and Limitations

Plasmonics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Язык: Английский

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Perturbation-Theory Machine Learning for Multi-Objective Antibacterial Discovery: Current Status and Future Perspectives

Applied Sciences, Год журнала: 2025, Номер 15(3), С. 1166 - 1166

Опубликована: Янв. 24, 2025

Antibacterial drugs (commonly known as antibiotics) are essential for eradicating bacterial infections. Nowadays, antibacterial discovery has become an imperative need due to the lack of efficacious antibiotics, ever-increasing development multi-drug resistance (MDR), and withdrawal many pharmaceutical industries from programs. Currently, drug is widely recognized a multi-objective optimization problem where computational approaches could play pivotal role, enabling identification novel versatile agents. Yet, tackling complex phenomena such multi-genic nature infections MDR major disadvantage most modern methods. To best our knowledge, perturbation-theory machine learning (PTML) appears be only approach capable overcoming aforementioned limitation. The present review discusses PTML modeling suitable cutting-edge in discovery. In this sense, we focus attention on application models prediction and/or design multi-target (multi-protein or multi-strain) inhibitors context small organic molecules, peptide design, metal-containing nanoparticles. Additionally, highlight future applications drug-like chemotypes with multi-protein multi-strain activity.

Язык: Английский

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Copper Nanoparticles Synthesized by Chemical Reduction with Medical Applications

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1628 - 1628

Опубликована: Фев. 14, 2025

Copper nanoparticles (CuNPs) have attracted attention due to their low cost and high specific surface area. In this work, a simple inexpensive two-step synthesis method was proposed prepare highly stable well-dispersed spherical CuNPs in solution with particle size of approximately 37 nm. Synthesis carried on the presence complexing agent trisodium citrate (TSC), while for chemical reduction step, sodium borohydride (NaBH4) used. Taking into account potential type nanoparticles, characterization represent current relevant topic field. The ability control size, shape properties by adjusting parameters (pH, precursor:stabilizer:reductant ratio, homogenization time, temperature) offers extraordinary flexibility development these materials. combination techniques such as SEM, EDX, UV-Vis, Raman, FT-IR AFM provides thorough understanding structure CuNPs, allowing modulation obtained desired direction. Based studies, copper mechanism proposed. For theoretical verification experimentally Mie theory applied. A stability study synthesized optimal conditions performed using UV-Vis analysis at time intervals (1, 3, 30 60 days), sample being kept dark, inside drawer 25 °C. after setting (Cu(II):TSC:BH4+ = 1:1:0.2, pH 5, min temperature °C) were then tested highlight antibacterial effect some reference bacterial strains. demonstrated very good antimicrobial efficacy compared traditional antimicrobials, both Gram-negative Gram-positive bacteria. This may reduce resistance, an urgent medical issue. After evaluating cytotoxic effects SKBR3 cancer cell line, significant decrease proliferation observed 0.5 mg/mL concentration, 89% h cultivation. Higher concentrations induced more rapid effect, leading accelerated decline viability.

Язык: Английский

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Nanomedicines for treatment of full-thickness wound

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 417 - 438

Опубликована: Янв. 1, 2025

Язык: Английский

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