Skin Development and Disease: A Molecular Perspective

Current Issues in Molecular Biology, Год журнала: 2024, Номер 46(8), С. 8239 - 8267

Опубликована: Июль 30, 2024

Skin, the largest organ in human body, is a crucial protective barrier that plays essential roles thermoregulation, sensation, and immune defence. This complex undergoes intricate processes of development. Skin development initiates during embryonic stage, orchestrated by molecular cues control epidermal specification, commitment, stratification, terminal differentiation, appendage growth. Key signalling pathways are integral coordinating epidermis, hair follicles, sweat glands. The interplay among these vital for appropriate formation functionality skin. Disruptions multiple can give rise to spectrum skin diseases, from congenital disorders cancers. By delving into mechanisms implicated developmental processes, as well pathogenesis this narrative review aims present comprehensive understanding aspects. Such knowledge paves way developing innovative targeted therapies personalised treatment approaches various conditions.

Язык: Английский

---

Cancer Vaccines

Methods in pharmacology and toxicology, Год журнала: 2025, Номер unknown, С. 213 - 229

Опубликована: Янв. 1, 2025

---

An epigenetic regulator synergizes with alphavirus-mediated gene therapy via biomimetic delivery for enhanced cancer therapy

Trends in biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

---

Functionalization of rod-shaped plant viruses for biomedical applications

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Biological nanoparticles, particularly rod-shaped plant viruses, have emerged as promising candidates for various biomedical applications. This review focuses on the morphological characteristics and modification strategies of viruses such tobacco mosaic virus, potato virus X, papaya virus. These offer versatile approaches, including chemical, genetic, bio-modifications, well aspect ratio regulation. Their applications in drug delivery, antibacterial treatments, RNA bioimaging, immune modulation are extensively discussed. Rod-shaped exhibit unique advantages, uniformity size molecular weight, excellent biocompatibility, diverse modifiability inherent immunogenicity, making them highly suitable However, challenges remain their clinical translation. aims to provide insights into potential biological nanoparticles stimulate further research field virus-based biomaterials, which may lead innovative solutions immune-related therapies vaccine development.

Язык: Английский

---

Barriers to gene and protein delivery

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 1 - 34

Опубликована: Янв. 1, 2025

---

Periprosthetic osteolysis: Mechanisms and potential treatment strategies

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111758 - 111758

Опубликована: Март 1, 2025

Язык: Английский

---

Lipid nanoparticles for treatment of glioblastoma multiforme: current status of research and clinical translation

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106891 - 106891

Опубликована: Апрель 1, 2025

Язык: Английский

---

Systematic comparison of wide pore size exclusion chromatography columns for the characterization of gene therapy products

Journal of Chromatography A, Год журнала: 2025, Номер unknown, С. 465972 - 465972

Опубликована: Апрель 1, 2025

Язык: Английский

---

Exosomes as key mediators in immune and cancer cell interactions: insights in melanoma progression and therapy

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Апрель 19, 2025

Язык: Английский

---

Recent advances of engineered oncolytic viruses-based combination therapy for liver cancer

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Янв. 2, 2024

Abstract Liver cancer is a major malignant tumor, which seriously threatens human health and increases the economic burden on patients. At present, gene therapy has been comprehensively studied as an excellent therapeutic measure in liver treatment. Oncolytic virus (OV) kind of that can specifically infect kill tumor cells. After being modified by genetic engineering, specificity OV infection to cells increased, its influence normal reduced. To date, shown effectiveness safety experimental clinical studies variety tumors. Thus, this review primarily introduces current status different genetically engineered OVs used for cancer, focuses application target genes therapy, identifies problems encountered OVs-based combination corresponding solutions, will provide new insights into treatment cancer.

Язык: Английский

---