Biomolecules,
Год журнала:
2024,
Номер
14(12), С. 1592 - 1592
Опубликована: Дек. 12, 2024
HIF-1α
plays
a
crucial
regulatory
role
in
vascular
calcification
(VC),
primarily
influencing
the
osteogenic
differentiation
of
VSMCs
through
oxygen-sensing
mechanisms.
Under
hypoxic
conditions,
stability
increases,
avoiding
PHD
and
VHL
protein-mediated
degradation,
which
promotes
its
accumulation
cells
then
activates
gene
expressions
related
to
calcification.
Additionally,
modulates
metabolic
state
by
regulating
pathways
that
govern
switch
between
glycolysis
oxidative
phosphorylation,
thereby
further
advancing
process.
The
interaction
other
signaling
pathways,
such
as
nuclear
factor-κB,
Notch,
Wnt/β-catenin,
creates
complex
network
serves
critical
driving
force
VC.
Therefore,
deeper
understanding
mechanism
during
development
progression
VC
is
great
significance,
it
not
only
key
molecular
marker
for
pathological
mechanisms
but
also
represents
promising
target
future
anti-calcification
therapies.
Antioxidants,
Год журнала:
2025,
Номер
14(1), С. 108 - 108
Опубликована: Янв. 18, 2025
The
study
of
mitochondrial
dysfunction
has
become
increasingly
pivotal
in
elucidating
the
pathophysiology
various
cerebral
pathologies,
particularly
neurodegenerative
disorders.
Mitochondria
are
essential
for
cellular
energy
metabolism,
regulation
reactive
oxygen
species
(ROS),
calcium
homeostasis,
and
execution
apoptotic
processes.
Disruptions
function,
driven
by
factors
such
as
oxidative
stress,
excitotoxicity,
altered
ion
balance,
lead
to
neuronal
death
contribute
cognitive
impairments
several
brain
diseases.
Mitochondrial
can
arise
from
genetic
mutations,
ischemic
events,
hypoxia,
other
environmental
factors.
This
article
highlights
critical
role
progression
diseases
discusses
need
targeted
therapeutic
strategies
attenuate
damage,
restore
enhance
neuroprotection.
Molecules,
Год журнала:
2024,
Номер
29(19), С. 4770 - 4770
Опубликована: Окт. 9, 2024
Indole
derivatives
have
become
an
important
class
of
compounds
in
medicinal
chemistry,
recognized
for
their
wide-ranging
biological
activities
and
therapeutic
potential.
This
review
provides
a
comprehensive
overview
recent
advances
the
evaluation
indole-based
last
five
years,
highlighting
roles
cancer
treatment,
infectious
disease
management,
anti-inflammatory
therapies,
metabolic
disorder
interventions,
neurodegenerative
management.
shown
significant
efficacy
targeting
diverse
pathways,
making
them
valuable
scaffolds
designing
new
drugs.
Notably,
these
demonstrated
ability
to
combat
drug-resistant
cells
pathogens,
breakthrough
field,
offer
promising
options
chronic
diseases
such
as
diabetes
hypertension.
By
summarizing
key
findings
exploring
underlying
mechanisms,
this
underscores
potential
indole
addressing
major
healthcare
challenges,
thereby
instilling
hope
optimism
field
modern
medicine.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 936 - 936
Опубликована: Янв. 23, 2025
Hypoxia
is
a
well-known
characteristic
of
the
tumor
microenvironment
which
significantly
influences
cancer
development
and
closely
linked
to
unfavorable
outcomes.
Long
noncoding
RNAs
(lncRNAs),
are
part
genome,
have
garnered
increasing
attention
because
their
varied
functions
in
metastasis.
(lncRNAs)
defined
as
longer
than
200
nucleotides,
they
regulate
diverse
cellular
processes
by
modulating
gene
expression
at
transcriptional,
post-transcriptional
epigenetic
levels.
well-established
environmental
factor
enhances
metastasis
solid
tumors.
Epithelial-mesenchymal
transition
(EMT)
represents
one
key
mechanisms
triggered
hypoxia
contributes
Numerous
lncRNAs
been
identified
being
upregulated
hypoxia.
These
contribute
toward
cell
migration,
invasion
Recent
studies
crucial
role
for
these
hypoxia-induced
chemotherapy
resistance.
hypoxia-related
can
be
plausible
therapeutic
targets
devising
effective
therapies.
Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Апрель 1, 2025
Abstract
Ferroptosis
represents
an
emerging,
iron-dependent
form
of
cell
death
driven
by
lipid
peroxidation.
In
recent
years,
it
has
garnered
significant
attention
in
the
realm
cancer
immunotherapy,
particularly
studies
involving
immune
checkpoint
inhibitors.
This
not
only
enhances
our
comprehension
tumor
microenvironment
but
is
also
considered
a
promising
therapeutic
strategy
to
address
resistance,
investigate
activation
mechanisms,
and
facilitate
development
vaccines.
The
combination
immunotherapy
with
ferroptosis
provides
innovative
targets
fresh
perspectives
for
advancing
treatment.
Nevertheless,
cells
appear
possess
wider
array
evasion
strategies
compared
CD8
+
T
cells,
which
have
been
conclusively
shown
be
more
vulnerable
ferroptosis.
Furthermore,
TME
can
create
favorable
environment
survival
invasion.
Under
this
premise,
both
inducing
inhibiting
will
impact
antitumor
immunity
some
extent,
even
make
final
result
run
counter
purpose.
paper
systematically
elucidates
dual-edged
sword
role
process
briefly
outlining
complexity
within
TME.
It
explores
potential
side
effects
associated
ferroptosis-inducing
therapies
critically
considers
combined
application
ferroptosis-based
ICIs.
highlights
current
challenges
faced
approach
points
out
future
directions
development.
Cancers,
Год журнала:
2024,
Номер
16(11), С. 2089 - 2089
Опубликована: Май 30, 2024
Background:
The
study
aims
to
investigate
the
role
of
hypoxia-inducible
factors
(HIFs)
in
development,
progression,
and
therapeutic
potential
glioblastomas.
Methodology:
study,
following
PRISMA
guidelines,
systematically
examined
hypoxia
HIFs
glioblastoma
using
MEDLINE
(PubMed),
Web
Science,
Scopus.
A
total
104
relevant
studies
underwent
data
extraction.
Results:
Among
studies,
global
contributions
were
diverse,
with
China
leading
at
23.1%.
most
productive
year
was
2019,
accounting
for
11.5%.
Hypoxia-inducible
factor
1
alpha
(HIF1α)
frequently
studied,
followed
by
2
(HIF2α),
osteopontin,
cavolin-1.
Commonly
associated
pathways
include
glucose
transporter
(GLUT1)
3
(GLUT3)
receptors,
vascular
endothelial
growth
(VEGF),
phosphoinositide
3-kinase
(PI3K)-Akt-mechanistic
target
rapamycin
(mTOR)
pathway,
reactive
oxygen
species
(ROS).
HIF
expression
correlates
various
hallmarks,
including
survival,
neovascularization,
metabolism,
migration,
invasion.
Conclusion:
Overcoming
challenges
such
as
treatment
resistance
absence
biomarkers
is
critical
effective
integration
HIF-related
therapies
into
aim
optimizing
patient
outcomes.
The
element
that
causes
hypoxia
when
the
von
Hippel-Lindau
(VHL)
protein
is
not
functioning
hypoxia-inducible
factor
1-alpha
(HIF-1α),
which
essential
linked
to
cell
control
under
hypoxia.
Consequently,
in
situations
where
cells
are
oxygen-deficient,
HIF-1α
carries
out
a
variety
of
functions.
Citations
relevant
literature
support
notion
regulates
mitochondrial
and
glycolytic
pathways,
as
well
transition
from
former
latter.
Cells
with
limited
oxygen
supply
benefit
this
change,
especially
beneficial
for
inhibition
electron
transport
chain
enhanced
uptake
glucose
lactate.
During
hypoxic
stress,
also
controls
proline
transporters
such
lactate
dehydrogenase
A
(LDHA)
transporter
1
(GLUT1).
These
mechanisms
help
return
homeostasis.
Therefore,
through
metabolic
change
promoting
adenosine
triphosphate
(ATP)
synthesis
reducing
reactive
species
(ROS)
creation,
may
have
role
oxidative
stress
cells.
This
evidence,
describes
function
many
molecular
further
supports
it
prognostic
contributes
adaption.
Understanding
more
about
disorders,
including
inflammation,
cancer,
ischemia,
possible
because
HIF-1α's
effect
on
changes.
Gaining
knowledge
battle
between
metabolism,
directed
by
HIF-1α,
would
advance
research
pathophysiological
involving
dysregulated
metabolism.
Frontiers in Immunology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 6, 2025
It
is
widely
accepted
that
cancer
mostly
arises
from
random
spontaneous
mutations
triggered
by
environmental
factors.
Our
theory
challenges
the
idea
of
somatic
mutation
(SMT).
The
SMT
does
not
fit
well
with
Charles
Darwin's
evolution
in
same
relatively
few
would
occur
so
frequently
and
these
lead
to
death
rather
than
survival
fittest.
However,
it
under
evolution,
if
we
were
look
at
vantage
point
pathogens
their
supporting
microbial
communities
colonizing
humans
mutating
host
cells
for
own
benefit,
as
give
them
an
evolutionary
advantage
they
are
capable
selecting
genes
mutate
inserting
DNA
or
RNA
into
hosts.
In
this
article,
provide
evidence
tumors
actually
complex
composed
various
microorganisms
living
within
biofilms
encapsulated
a
hard
matrix;
what
cause
genetic
seen
control
angiogenesis;
spread
hiding
tumor
M2
M2-like
macrophages
other
phagocytic
immune
traveling
inside
distant
sites
camouflaged
platelets,
which
also
reprogram,
prepare
site
metastasis;
risk
factors
sources
energy
able
utilize;
that,
accordance
our
previous
unifying
disease,
utilize
melanin
building
sustaining
metastasis.
We
propose
paradigm
shift
understanding
is,
and,
thereby,
different
trajectory
avenues
treatment
prevention.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 10, 2025
Diabetic
kidney
disease
is
one
of
the
common
complications
in
diabetic
patients
and
has
gradually
become
an
important
pathogenic
factor
chronic
disease.
Therefore,
studying
mechanisms
its
occurrence
development
great
significance
for
prevention
treatment
Some
researchers
have
pointed
out
that
there
a
phenomenon
hypoxia
tissue
believe
hypoxia-inducible
factor-1α
closely
related
to
progression
Additionally,
homeostasis
zinc
plays
key
role
body's
adaptation
hypoxic
environments.
However,
specific
relationship
among
these
three
factors
remains
unclear.
This
article
provides
detailed
review
multiple
roles
pathogenesis
disease,
including:
regulating
angiogenesis,
increasing
expression
erythropoietin,
modulating
oxidative
stress
through
PI3K/AKT
HIF-1α/HO-1
pathways,
promoting
inflammatory
cell
infiltration
release
induce
responses,
facilitating
epithelial-mesenchymal
transition,
pathological
fibrotic
factors,
ultimately
leading
renal
fibrosis.
Furthermore,
HIF-1α
also
participates
such
as
apoptosis,
inducing
mitochondrial
autophagy,
vascular
calcification.
At
same
time,
this
clarifies
regulatory
trace
element
on
references
insights
further
research
