A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12091 - 12091
Опубликована: Ноя. 11, 2024
The
main
goal
of
this
systematic
review
on
the
flavonol
class
secondary
metabolite
quercetin
is
to
evaluate
and
summarize
existing
research
quercetin's
potential
health
benefits,
therapeutic
properties,
effectiveness
in
disease
prevention
treatment.
In
addition
evaluating
for
drug
development
with
fewer
side
effects
lower
toxicity,
type
attempts
collect
scientific
evidence
addressing
roles
as
an
antioxidant,
anti-inflammatory,
antibacterial,
anticancer
agent.
first
part,
we
analyze
various
flavonoid
compounds,
focusing
their
chemical
structure,
classification,
natural
sources.
We
highlight
most
recent
biological
activities
reported
literature.
Among
these
pay
special
attention
quercetin,
detailing
its
physicochemical
process
biosynthesis
plants.
also
present
sources
emphasize
such
antioxidant
anti-inflammatory
effects.
Additionally,
discuss
methods
enhance
bioavailability,
analyzing
latest
effective
delivery
systems
based
quercetin.
Язык: Английский
Potential health benefits of berry bioactives, their use as nutraceuticals, and regulatory issues
Elsevier eBooks,
Год журнала:
2025,
Номер
unknown, С. 131 - 169
Опубликована: Янв. 1, 2025
Язык: Английский
Genus Sambucus: Exploring Its Potential as a Functional Food Ingredient with Neuroprotective Properties Mediated by Antioxidant and Anti-Inflammatory Mechanisms
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7843 - 7843
Опубликована: Июль 18, 2024
The
genus
Sambucus,
mainly
Sambucus
nigra,
has
emerged
as
a
valuable
source
of
bioactive
compounds
with
potential
neuroprotective
properties.
This
review
explores
the
antioxidant,
anti-inflammatory,
and
neuroregenerative
effects
Sambucus-derived
their
implications
for
brain
health
cognitive
function.
In
vitro
studies
have
demonstrated
ability
extracts
to
mitigate
oxidative
stress,
modulate
inflammatory
responses,
promote
neural
stem
cell
proliferation
differentiation.
vivo
using
animal
models
neurodegenerative
diseases,
such
Alzheimer’s
Parkinson’s,
shown
that
can
improve
function,
motor
performance,
neuronal
survival
while
attenuating
neuroinflammation
damage.
are
primarily
attributed
its
rich
content
polyphenols,
particularly
anthocyanins,
which
exert
benefits
through
multiple
mechanisms,
including
modulation
signaling
pathways
involved
in
inflammation,
apoptosis,
mitochondrial
stress.
Furthermore,
functional
food
ingredient
is
discussed,
highlighting
application
various
products
challenges
associated
stability
bioavailability
compounds.
provides
comprehensive
overview
current
state
research
on
derivatives,
offering
insights
development
dietary
strategies
prevent
age-related
decline.
Язык: Английский
Antimicrobial and Antioxidant Properties of Sambucus nigra L. (Elderflower) Oil: A Molecular Docking and Biochemical Study
Agronomy,
Год журнала:
2025,
Номер
15(2), С. 310 - 310
Опубликована: Янв. 26, 2025
The
present
study
investigates
the
antimicrobial
and
antioxidant
potential
of
an
essential
oil
extracted
from
Sambucus
nigra
L.
flowers.
Using
hydrodistillation,
volatile
compounds
were
profiled
through
GC–MS
analysis
for
fatty
acid
profile
compounds.
demonstrated
a
balanced
composition
saturated
acids,
monounsaturated
polyunsaturated
with
oleic,
palmitic,
linolenic
acids
as
key
contributors.
revealed
dominance
nonanal,
cis-rose
oxide,
trans-rose
2-Pentadecanone,
6,10,14-trimethyl-.
Antioxidant
activity
was
assessed
using
1,1-Diphenyl-2-Picrylhydrazyl
radical
scavenging
assay,
showing
significant
inhibition,
IC50
value
2.52
mg/mL.
Antimicrobial
efficacy
determined
against
Gram-positive,
Gram-negative,
fungal
strains,
highlighting
moderate
inhibitory
Streptococcus
pyogenes,
Staphylococcus
aureus,
Candida
albicans.
S.
exhibited
more
especially
C.
albicans,
compared
to
bacterial
which
might
be
attributed
differences
in
permeability
cell
wall
between
fungi
bacteria.
Among
bacteria,
E.
coli
most
susceptible,
while
P.
aeruginosa
showed
resistance,
agreement
its
known
stronger
membrane
structure
efflux
mechanisms.
Molecular
docking
conducted
evaluate
effects
on
microbial
proteins
corroborate
observed
vitro
outcome.
results
indicated
that
2-pentadecanone,
6,10,14-trimethyl-
displayed
interesting
hydrophilic
hydrophobic
binding
interactions
putative
proteins.
These
findings
elucidate
bioactive
role
oils,
suggesting
their
therapeutic
agents
managing
oxidative
stress
infections.
Язык: Английский
Exploring Therapeutic Potential of Malcolmia Aegyptiaca Spr. and Matthiola Livida DC. Extracts in Rat Models Using Hot-Plate, Writhing and Carrageenan-Induced Paw Edema Tests
Acta Medica Bulgarica,
Год журнала:
2024,
Номер
51(s2), С. 102 - 109
Опубликована: Сен. 1, 2024
Abstract
Background
Malcolmia
aegyptiaca
(locally
known
as
El
Harra)
and
Matthiola
livida
Chegara)
are
medicinal
plants
traditionally
used
to
relieve
pain
reduce
inflammation.
Little
is
about
the
flavonoid
content
or
analgesie
anti-inflammatory
properties
of
these
plants.
Aims
The
aim
study
was
explore
natural
therapeutic
potential
two
xerophytic
plants,
M.
Spr.
DC,
for
analgesic
activities
using
hot-plate,
writhing
carrageenan-induced
paw
edema
tests.
Materials
Methods
Flavonoid
quantified
AICI3
reagent.
Analgesic
activity
assessed
hot-plate
(in
concentrations
30
80
mg/kg)
tests
(20
40
in
rats
treated.
Anti-inflammatory
evaluated
model
treated
with
doses
(25
50
plant
extracts.
Results
extract
had
a
higher
concentration
compared
extract.
Both
extracts
exhibited
dose-dependent
effects
test,
inducing
stronger
more
sustained
analgesia.
displayed
weaker
anti-nociceptive
test
standard
NSAID
indomethacin.
were
mainly
observed
at
dose
test.
demonstrated
model,
exhibiting
greater
inhibition
later
time
points.
Conclusion
methanolic
possess
properties,
supporting
their
traditional
use
inflammation
management.
Further
research
needed
elucidate
active
components
mechanisms
action
responsible
activities.
Язык: Английский
Effect of Sambucus nigra inflorescence supplementation on the organism of rats fed a high-fat diet
Regulatory Mechanisms in Biosystems,
Год журнала:
2024,
Номер
15(4), С. 992 - 999
Опубликована: Окт. 16, 2024
Medicinal
plants
are
interesting
as
mild
and
effective
therapeutic
agents
for
treating
correcting
metabolic
disorders
caused
by
an
unbalanced
diet.
Sambucus
nigra
has
antioxidant
anti-inflammatory
properties,
which
used
to
alleviate
cardiovascular,
neurodegenerative
inflammatory
diseases.
It
also
antidiabetic,
anticancer,
antiviral
immunostimulant
properties.
The
effect
of
adding
crushed
S.
inflorescences
the
diet
rats
was
modelled
under
experimental
laboratory
conditions.
For
this
purpose,
three
groups
5
animals
each
were
formed
from
white
male
that
fed
a
high-fat
(15%
vegetable
fat)
35
days,
with
addition
0.5%
2.0%
dry
inflorescences.
overall
introducing
plant
in
on
body
weight
gain,
relative
some
internal
organs
state
processes
model
assessed.
In
group,
increased
108%
baseline
at
end
experiment.
Supplementing
dose
promoted
increase
gain
(up
112%
initial
weight),
slowdown
even
decrease
A
supplemented
significantly
weights
liver,
lung
spleen,
whereas
did
not
cause
significant
changes
these
indices.
reduced
blood
glucose
concentration.
Both
doses
level
low-density
lipoprotein
(LDL)
cholesterol
blood,
high-density
(HDL)
cholesterol,
while
amount
total
change
atherogenicity
index
decreased.
protein
mineral
metabolism,
but
affect
bilirubin
especially
levels
direct
indirect
bilirubin.
elderflower
alpha-amylase
activity,
ALT
activity
strong
De
Ritis
ratio.
results
show
possibility
using
dried
dietary
supplement
diets
correct
possible
disorders.
Язык: Английский