A Multitargeted Approach to Breast Cancer Therapy: Exploring the Therapeutic Potential of Afzelin as a Combination Agent with FDA-Approved Breast Cancer Drugs.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 28, 2025

Afzelin, a natural flavonoid, has demonstrated promising anticancer properties, warranting further investigation into its molecular mechanisms and therapeutic potential in breast cancer treatment. This study use various insilico tools to explore Afzelin's interactions with key targets implicated cancer, including estrogen receptors (ERα ERβ), aromatase, HER2 receptor, kinases, PARP enzyme, microtubules, immune checkpoint proteins. Molecular docking simulation studies revealed stable binding modes of Afzelin highlighting modulate these critical pathways. AdmetSAR3.0 confirmed Afzelin’s favorable pharmacokinetic toxicity profiles, supporting as drug-like molecule. These findings propose candidate for combination therapy FDA-approved drugs, offering synergistic strategy target multiple pathways involved cancer. provides foundation preclinical clinical evaluations the context therapeutics.

Язык: Английский

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From fruit to functional food: Eriobotrya japonica’s potential in managing obesity and Alzheimer's disease

South African Journal of Botany, Год журнала: 2025, Номер 180, С. 531 - 540

Опубликована: Март 31, 2025

Язык: Английский

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Neuroprotective effects of Withania somnifera on ischemic stroke are mediated via anti-inflammatory response and modulation of neurotransmitter levels

Neurochemistry International, Год журнала: 2024, Номер unknown, С. 105867 - 105867

Опубликована: Сен. 1, 2024

Язык: Английский

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Anabasis setifera leaf extract from arid habitat: A treasure trove of bioactive phytochemicals with potent antimicrobial, anticancer, and antioxidant properties

PLoS ONE, Год журнала: 2024, Номер 19(10), С. e0310298 - e0310298

Опубликована: Окт. 25, 2024

The main objective of this study was to evaluate the biological activities Anabasis setifera extract, including its antimicrobial, anticancer, and antioxidant properties. In current study, leaves extract evaluated for phytochemical analyses. Ethyl acetate (EA-AS) exhibited promising antimicrobial activity toward Escherichia coli, Staphylococcus aureus, Salmonella typhimurium, Bacillus subtilis, Candida albicans, Aspergillus brasiliensis, fumigatus with MICs 62.5, 125, 31.25, 125 μg/mL respectively. Moreover, EA-AS showed anticancer at safe concentrations, where IC50 were 36.4 44 Hep-G2 MCF-7 cancerous cell lines. found contain 55 significant compounds identified through gas chromatography mass spectrophotometry (GCMS). most abundant 1,4-dimethoxy-6,7,8,9-tetrahydro-5-benzocycloheptenone (26.04%), hexa-2,4-diyn-1-ylbenzene (8.40%), dihydrobenzo[b]fluoranthene (6.10%), ethanone, 1-[2,3-dihydro-2-(1-methylethenyl)-5-benzofuranyl valerenol (4.08%). GC analysis confirmed properties AS by detecting several activity, hexa-2,4-diyn-1-ylbenzene, nerolidol, spathulenol, -naphthalenem ethanol, decahydro-4-trimethyl-8-methylene, hexadecenoic acid, tremetone, desmethoxyencecalin, heptadecyn-1-ol, thunbergol, hexadecanol, dotriacontane, taylorione, ligulatin, retinoic falcarinol. reveals that it is a rich source valuable phytochemicals: total Phenolic Content: 4,264 /, suggesting substantial pharmacological potential. Total tannin content: 391.17 μg/mL, indicating potential applications in industries like nutraceuticals, pharmaceuticals, cosmetics. flavonoid content exceptionally high 5,163 while alkaloid measured 1,036.26 μg/mL. Additionally, demonstrated an EC50 30.6 conclusion, comprehensive immense as phytochemicals diverse bioactivities, warranting further in-depth studies unlock full pharmaceutical commercial prospects. Our results suggest prospects potent antioxidant.

Язык: Английский

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Mechanistic Insights and Therapeutic Potential of Astilbin and Apigenin in Diabetic cardiomyopathy

Heliyon, Год журнала: 2024, Номер 10(21), С. e39996 - e39996

Опубликована: Ноя. 1, 2024

Язык: Английский

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Platycladus orientalis (L.) Franco demonstrates effective anti-psoriasis effects by inhibiting PDE4 with favorable safety profiles

Chinese Chemical Letters, Год журнала: 2024, Номер unknown, С. 110795 - 110795

Опубликована: Дек. 1, 2024

Язык: Английский

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