Heliyon,
Год журнала:
2024,
Номер
10(24), С. e41068 - e41068
Опубликована: Дек. 1, 2024
Luteolin
is
a
kind
of
natural
flavonoid,
widely
existing
in
variety
plants,
has
been
revealed
to
have
wide
range
biological
activities.
In
recent
years,
the
research
results
luteolin
are
abundant.
Here
we
review
latest
order
provide
new
ideas
for
further
and
development
luteolin.
this
paper,
focus
search
was
published
between
2010
2024
on
extraction
determination
luteolin,
activities,
application
products.
A
comprehensive
using
keyword
"luteolin"
conducted
PubMed,
Web
Science
WIPO
databases.
Through
collection
related
literature,
paper
summarized
techniques
including
immersion
extraction,
solvent
ultrasonic-assisted
supercritical
fluid
so
on.
The
methods
include:
thin
layer
chromatography
(TLC),
high
performance
liquid
(HPLC),
capillary
electrophoresis
(CE),
electrochemical
method
(ED)
addition,
activities
antioxidant,
anti-inflammatory,
anti-tumor,
antibacterial,
analgesic
on,
were
described.
And
as
main
component
product
being
gradually
developed,
used
field
food,
medicine
cosmetics.
This
provides
reference
study
Critical Reviews in Biotechnology,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Янв. 6, 2025
This
comprehensive
review
aims
to
explore
and
consolidate
the
current
knowledge
on
dendrobine,
including
its
biological
activities,
molecular
mechanisms
of
action,
effects
various
physiological
processes,
potential
toxicity,
safety
considerations,
in
order
unlock
full
applications.
Dendrobine
has
diverse
effects,
anti-inflammatory,
antioxidant,
neuroprotective,
immunomodulatory,
anticancer
effects.
also
exerts
neuroprotective
by
boosting
neuronal
survival,
reducing
neuroinflammation,
regulating
neurotransmitter
release.
immunomodulatory
that
control
immune
cell
function
modify
immunological
responses.
exhibits
properties
decreasing
tumor
angiogenesis
metastasis,
causing
apoptosis
cancer
cells,
inhibiting
growth.
discusses
idea
a
circular
economy
produce
researching
cutting-edge
sustainable
methods
maximize
resource
efficiency
reduce
environmental
Additionally,
supporting
principles
for
production
outlining
future
study
areas,
this
discovery
will
help
use
dendrobine
variety
applications
while
preserving
environment.
Future
research
should
focus
advancing
application
personalized
medicine,
exploring
green
bioproduction
methods,
ensuring
ethical
sourcing
practices.
An
enhanced
understanding
synergistic
therapies
could
revolutionize
healthcare,
whereas
conservation
efforts
safeguard
ecological
impact.
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(3)
Опубликована: Март 1, 2025
ABSTRACT
Phytochemicals
are
bioactive
compounds
found
in
plants
that
play
a
key
role
promoting
health
and
preventing
diseases.
Present
fruits,
vegetables,
grains,
seed
oils,
these
considered
safe
for
consumption
due
to
the
co‐evolution
adaptation
between
mammals
plants.
Due
their
wide‐ranging
biological
effects,
they
have
attracted
considerable
research
interest.
This
comprehensive
review
explores
mechanisms
of
action,
benefits,
applications
dietary
phytochemicals,
with
particular
focus
on
groups
such
as
polyphenols,
flavonoids,
carotenoids.
Research
shows
phytochemicals
interact
nuclear
membrane
receptors,
influence
metabolic
pathways,
affect
epigenetic
modifications.
Our
highlights
broad
range
activities
compounds,
including
antioxidant,
antibacterial,
anti‐inflammatory,
anti‐diabetic,
anticancer
all
which
contribute
health‐promoting
properties.
Clinical
evidence
supports
prevention
management
diseases
cardiovascular
disorders,
conditions,
cancer,
diets
rich
being
linked
lower
risk
disease.
also
at
cutting
edge
food
preservation,
supplements,
emerging
medical
treatments.
Additionally,
we
identified
advancements
extraction
identification
techniques,
particularly
metabolomics,
further
enhance
areas.
Despite
promising
challenges
bioavailability,
regulatory
barriers,
need
robust
clinical
trials
persist.
However,
innovative
delivery
systems
like
nanoparticles,
liposomes,
encapsulation
offer
potential
solutions
bioavailability
by
improving
absorption
stability.
The
concludes
emphasizing
personalized
nutrition
combination
therapies
benefits
while
stressing
methods,
trials,
bioavailability.
Drug Development and Industrial Pharmacy,
Год журнала:
2025,
Номер
unknown, С. 1 - 16
Опубликована: Фев. 24, 2025
Paracetamol
(PAC)
overdose
causes
acute
liver
injury
through
oxidative
stress,
inflammation,
and
apoptosis.
While
N-acetyl
cysteine
(NAC)
is
the
standard
treatment,
fucoxanthin
(FUC),
a
carotenoid
from
brown
seaweed,
has
shown
hepatoprotective
effects
in
animal
studies,
but
its
role
PAC
toxicity
unclear.
Compared
to
NAC,
this
study
assessed
potential
of
oral
FUC
solution
towards
PAC-induced
rat's
liver.
was
formulated
as
pharmaceutical
characterized
via
UV-VIS
spectroscopy.
Six
groups
male
Wistar
rats
each
contain
five
which
are
total
thirty
rats:
negative
control
(NC),
positive
(PC,
2
g/kg
PAC),
NAC
(1200
mg/kg),
three
doses
(100,
200,
500
mg/kg)
for
seven
days,
with
administered
on
day-8.
Liver
tissues
were
analyzed
gene
expression,
histology.
clear
absorbance
at
433
nm.
caused
30%
mortality
(p
<
0.01
vs.
others).
reduced
ALT
(56%),
AST
(78%),
ALP
(28%),
increased
TP
by
25%
0.001
PC).
mg/kg
(F500)
superior,
reducing
(82%),
(93%),
(40%),
increasing
(35%)
NAC).
CYP2E1/CYP3A2
apoptosis
markers,
suppressed
Nrf2/AMPK/AKT1.
F500
improved
antioxidants,
apoptosis,
enhanced
Nrf2/AMPK
pathway,
downregulated
0.01).
FUC,
particularly
mg/kg,
offers
significant
hepatoprotection
against
modulating
drug
metabolizing
enzymes
enhancing
antioxidant
defences,
warranting
further
research.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2584 - 2584
Опубликована: Март 13, 2025
This
study
aims
to
establish
a
hypobaric
hypoxia-induced
immune
injury
model
and
investigate
the
intervention
therapeutic
effects
of
Astragaloside
IV
(AS-IV).
simulated
hypoxia
stimulation
in
mice
at
an
altitude
7000
m
on
plateau
for
1,
3,
5,
7
days.
HE
staining
transcriptomic
analysis
were
performed
mouse
spleens.
In
addition,
AS-IV
was
selected
prevention
treatment,
validated
by
flow
cytometry,
ELISA,
Q-PCR.
The
results
showed
that
under
hypoxic
conditions
5
days,
peripheral
blood
lymphocytes
decreased,
CD45+
cells,
CD3+
T
CD3+CD4+
CD4+/CD8+
cell
ratio
spleen
all
decreased.
can
significantly
alleviate
pathological
damage
spleen,
decrease
serum
levels
IL-2
IL-6,
increase
IL-4
IL-10,
raise
cells
while
increasing
CD4+IFN-γ+cells
reducing
ROS
apoptosis
content
relevant
mRNA
Th1/Th2
pathway.
summary,
simulating
days
stable
model,
effectively
injury.
