Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
Язык: Английский
Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 176 - 176
Опубликована: Янв. 30, 2025
Proton therapy represents a groundbreaking advancement in cancer radiotherapy, leveraging the unique spatial energy distribution of protons to deliver precise, high-dose radiation tumors while sparing surrounding healthy tissues. Despite its clinical success, proton faces challenges optimizing therapeutic precision and efficacy. Recent research has highlighted potential gold nanoparticles enhance outcomes. Due their high atomic number favorable biological properties, act as radiosensitizers by amplifying generation secondary electrons reactive oxygen species upon irradiation. This enhances DNA damage tumor cells preserving Additionally, functionalization with tumor-targeting ligands offers improved precision, making more effective against broader range cancers. review synthesizes current knowledge on mechanisms nanoparticle radiosensitization, preclinical evidence, technological hurdles that must be addressed integrate this promising approach into practice, aiming advance efficacy accessibility therapy.
Язык: Английский
Процитировано
1
Medical Oncology, Год журнала: 2025, Номер 42(4)
Опубликована: Март 17, 2025
Abstract Glioblastoma is the most common and highly invasive glial tumor, significantly reducing patient survival. Current therapeutic approaches have limited success rates. Plant-derived nanovesicles are a rapidly developing area, recognized for their exceptional biofunctional properties, emerging as promising approach in cancer treatment. The present study focuses on isolation of from Viburnum opulus fruits using cost-effective method that includes polymer-based exosome precipitation buffer size exclusion chromatography, followed by characterization. Morphological analysis via Field Emission Scanning Electron Microscopy Transmission revealed ranging oval to elliptical shapes, with average diameters 54.23 nm 41.21 nm, respectively. Dynamic light scattering determined 45.36 indicating presence nanovesicles, zeta potential was − 2.87 mV. Biochemical characterization showed total protein phenolic concentrations 1534 ± 97.78 µg/ml 4.270 0.66 mg gallic acid equivalents/L, respectively, antioxidant status values 3.83 0.37 mmol Trolox equivalents/L. Based IC50 values, these were 7.5 times more toxic U87MG human glioblastoma cells compared healthy dermal fibroblasts. Analyses including clonogenic cell survival, wound healing, apoptosis, status, oxidant continued only cells, fibroblasts low response nanovesicle Qualitative quantitative assessments demonstrated -derived effectively inhibited proliferation migration. Due non-toxic, anticancer, hold significant management. Graphical abstract
Язык: Английский
Процитировано
0
Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107495 - 107495
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Март 20, 2025
The isoquinoline alkaloid berberine, a bioactive compound derived from various plants, has demonstrated extensive therapeutic potential. However, its clinical application is hindered by poor water solubility, low bioavailability, rapid metabolism, and insufficient targeting. Metal-based nanoplatforms offer promising solutions, enhancing drug stability, controlled release, targeted delivery. This review comprehensively explores the synthesis, physicochemical properties, biomedical applications of metal-based nanocarriers, including gold, silver, iron oxide, zinc selenium, magnetic nanoparticles, for berberine delivery to improve berberine's efficacy. Recent advancements in nanocarrier systems have significantly improved cellular uptake, extending circulation time, enabling site-specific encounter several limitations potential toxicity, limited large-scale productions, regulatory constraints. Addressing these necessitates studies on biocompatibility, long-term safety, translation. By summarizing latest innovations perspectives, this aims guide future research toward optimizing berberine-based nanomedicine
Язык: Английский
Процитировано
0
Nano TransMed, Год журнала: 2025, Номер unknown, С. 100080 - 100080
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177603 - 177603
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Апрель 16, 2025
Язык: Английский
Процитировано
0