Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 73 - 104
Опубликована: Янв. 1, 2025
ACS Applied Polymer Materials, Год журнала: 2022, Номер 4(10), С. 7228 - 7239
Опубликована: Сен. 15, 2022
pH-responsive dual-loaded nanoplatforms based on polyamidoamine dendrimer with a hydroxyl-terminated surface (PAMAM–OH), generations 3, 4, and 5 (G3, G4, G5, respectively), were loaded Peganum harmala alkaloid extracts (H) tannic acid (TA) tested against breast cancer cells. G3 dendrimers encapsulating the drugs showed smallest sizes, PDI, highest ζ-potential entrapment efficiencies compared to those of G4 G5. either doxorubicin (DOX), H, or TA H+TA prepared. The average diameters designed DOX@G3, H@G3, TA@G3, H+TA@G3 NPs 78 ± 5.1, 122 3.7, 141 2.8, 192 1.9 nm, respectively. All prepared exhibited high positive charges efficiencies. Release studies ability release their cargo selectively in cancerous cells' extracellular pH (pH 5.5) via pH-triggered mechanism while maintaining an outstanding stability at physiological conditions 7.4). Furthermore, remarkable cytotoxic activities adenocarcinoma (MCF-7) cells IC50 values 2.6 0.08, 4.5 0.9, 1.7 0.6 μg/mL, respectively, as free TA, DOX, DOX@G3 (IC50 5.8 0.8, 7.2 1, 6.75 0.7, 4.7 0.8 μg/mL). formulated 11.8, 9.3, 5.3% increases late apoptosis MCF-7 relative respective forms, percentage In conclusion, PAMAM–OH dually alkaloids hold potential for effective treatment cancer.
Язык: Английский
Процитировано
23
International Journal of Biological Macromolecules, Год журнала: 2022, Номер 225, С. 1 - 12
Опубликована: Дек. 5, 2022
Язык: Английский
Процитировано
22
Cancers, Год журнала: 2022, Номер 14(19), С. 4918 - 4918
Опубликована: Окт. 7, 2022
At diagnosis, about 35% of pancreatic cancers are at the locally invasive yet premetastatic stage. Surgical resection is not a treatment option, leaving patients with largely incurable disease that often evolves to polymetastatic stage despite chemotherapeutic interventions. In this preclinical study, we hypothesized cancer metastasis can be prevented by inhibiting mitochondrial redox signaling MitoQ, mitochondria-targeted antioxidant. Using four different cell lines, report that, clinically relevant concentrations (100-500 nM), MitoQ selectively repressed mesenchymal respiration, which involved inhibition expression PGC-1α, NRF1 and reduced electron-transfer-chain complexes I III. consequently decreased membrane potential superoxide production these cells. Phenotypically, further inhibited migration, invasion, clonogenicity stem markers. It ~50% metastatic homing human MIA PaCa-2 cells in lungs mice. We show combination treatments chemotherapy conceivable. Collectively, study indicates possible therapeutic option inhibit progression cancer.
Язык: Английский
Процитировано
19
Journal of Food Science, Год журнала: 2023, Номер 88(4), С. 1325 - 1335
Опубликована: Фев. 14, 2023
The binding of pesticide residues and fruit components may have a profound impact on dissipation the functional characteristics corresponding components. Therefore, interaction between boscalid tannic acid (TA, representative phenolic in fruit) was systematically investigated using spectroscopic, thermodynamic, computational chemistry methods. A separable system designed to obtain boscalid-TA complex. Fourier transform infrared 1 H-NMR spectroscopies indicated formation hydrogen bonds Isothermal titration calorimetry showed that complex bound spontaneously through hydrophobic interactions (ΔG < 0, ΔH > ΔS 0), with constant 6.0 × 105 M-1 at 298 K. molecular docking results further confirmed level, energy -8.43 kcal mol-1 . In addition, TA significantly decreased antioxidant activity TA. residue characterized which reduced vitro properties PRACTICAL APPLICATION: This study provides reference for mechanisms food matrices, as well basis regulating bound-state food.
Язык: Английский
Процитировано
12
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 73 - 104
Опубликована: Янв. 1, 2025
Процитировано
0