Research for development, Год журнала: 2024, Номер unknown, С. 313 - 336
Опубликована: Дек. 23, 2024
Язык: Английский
European Journal of Dentistry, Год журнала: 2022, Номер 16(04), С. 848 - 855
Опубликована: Фев. 18, 2022
Topical application of ambonese banana (Musa paradisiaca var. sapientum (L.) kuntze) stem sap gel (GEGPA) on the socket wound area showed an increase in expression platelet-derived growth factor-BB, while decrease matrix metalloproteinase-2 and 9. The aim this study is to achieve standard formulation GEGPA through stability, viscosity, distribution area, drugs release for oral healing. This vitro vivo with randomized posttest only control group design. was formulated according composition each by adding hydroxypropyl methylcellulose (HPMC), Lexgard, propylene glycol, cold water obtain 100 g gel. Observations were made following tests: drug release, histopathological analysis tooth extraction Data analyzed using a one-way variance (α = 0.05) GraphPad Prism-8 statistical software. that stable against changes consistency, color, smell, homogeneity, pH value. There significant difference between groups respect viscosity (p 0.0001), adhesion 0.004), dispersion 0.000), fibroblast cell numbers days 3 5 0.007 p 0.001). no interaction active ingredients base all formulations. Formulation had better properties terms broad distribution, compared other groups. Application wounds proliferation cells 5. M. kuntze extract HPMC glycol obtained preparation, GEGPA, organoleptically met topical cavity.
Язык: Английский
Процитировано
9
Biointerface Research in Applied Chemistry, Год журнала: 2022, Номер 13(4), С. 391 - 391
Опубликована: Янв. 11, 2022
Ionic liquids (ILs) are gaining popularity due to their unique qualities, which include low vapor pressure, thermal stability, and non-flammability, as well strong ionic conductivity a wide electrochemical stability window. Ionogels (IGs) solid electrolytes that based on liquid (IL). Incorporation/entrapment of ILs in any inorganic or organic host material results the formation IGs. Furthermore, develop lithium-ion batteries (LIBs) with high capacity, rate capability, outstanding cycle this paper focuses clever methodologies for synthesizing organic, inorganic, hybrid host-based In review, ionogels described novel type characteristics an IL combined those another component, can be (low molecular weight gelator, biopolymer, etc.) (carbon nanotubes, silica, organic-inorganic (e.g., polymer fillers.
Язык: Английский
Процитировано
9
European Journal of Pharmaceutical Sciences, Год журнала: 2023, Номер 192, С. 106646 - 106646
Опубликована: Ноя. 19, 2023
Swallowing difficulties encountered by geriatric patients who undergo polypharmacy represent a significant challenge that hampers patient compliance and therapeutic management. As an appealing sensory-pleasing, chocolate-based formulations have emerged as potential alternative oral dosage form suitable for both the elderly paediatric populations. However, extent to which incorporation of drugs into chocolate matrix affects their availability remains unclear. Therefore, objective this investigation was explore in vitro vivo performance ibuprofen-based form. A based on dark model drug prepared at two distinct temperatures: 50 80°C. In release studies revealed ibuprofen formulated through co-melting 80°C exhibited statistically slower (p<0.05) compared 50°C FaSSGF (fasted-state simulated gastric fluid) lipolysis media. The enzymatic degradation presence lipase accelerated from matrices. To delve deeper bioavailability within formulations, we conducted assessment, comparing pharmacokinetic profiles its conventional suspension with our forms. notable drop maximum serum concentration when incorporated co-melted or solid-suspension no differences plasma exposure were observed between formulations. These findings shed light extend integrated various matrices, showcasing held these innovative
Язык: Английский
Процитировано
4
Pharmaceutics, Год журнала: 2024, Номер 16(3), С. 417 - 417
Опубликована: Март 18, 2024
Swallowing oral solid dosage forms is challenging for those who have medication swallowing difficulties, including patients with dysphagia. One option to mix the drug (whole or crushed) a thick vehicle (medication lubricant). Previous in vitro studies consistently suggest that vehicles could impact dissolution of forms, potentially influencing their therapeutic effectiveness, but do not account changes happen during processing and swallowing. This study aims investigate potential lubricants on release examine effect processing. In whole crushed paracetamol tablets mixed five commercially available (two IDDSI level 2, two 3, one 4) were tested without processing; lubricant with/without was placed mouth (five healthy volunteers), prepared swallowing, then expectorated assessed physical characteristics release. Medication lubricants, both alone tablets, showed significant decrease viscosity after Without processing, 3 4 significantly delayed tablets. After particularly there substantial increase rate. These findings testing overestimates dissolution. Therefore, using tests predict rate medications discouraged. It essential consider ways incorporate effects environment used administration.
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2024, Номер 16(5), С. 584 - 584
Опубликована: Апрель 25, 2024
The safe administration of solid oral dose forms in hospital inpatients with swallowing difficulties is challenging. aim this study was to establish the prevalence acute inpatients. A point completed at three time points. following data were collected: difficulties, methods used modify facilitate administration, appropriateness modification, and patient co-morbidities. an average 15.4% a 95% CI [13.4, 17.6] across studies. On average, 9.6% patients had no enteral feeding tube situ, 6.0% these receiving least one modified medicine. most common method form modification crushing, error rate approximately 14.4%. co-morbid condition hypertension, dysphagia appearing on problem list two (5.5%) difficulties. Inappropriate modifications can result harm. proactive approach, such as use screening tool identify required, mitigate risk inappropriate medicines overcome
Язык: Английский
Процитировано
1
European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 203, С. 106926 - 106926
Опубликована: Окт. 9, 2024
Acceptable swallowability and complete esophageal transit are decisive for the safe effective administration of solid oral dosage forms. This applies in particular to main user group medicines, older adults, who often suffer from swallowing difficulties. It is well known that surface properties play an important role this respect. In past, has led development numerous coating formulations tablets with improved swallowability. However, vitro especially vivo data investigating a positive effect different materials limited. Therefore, we investigated being based on polyvinyl alcohol, hydroxypropyl methylcellulose, copolymer methacrylate respect their influence tablet formulation. They were compared uncoated as hard gelatin capsules. Three assays suitable routine use pharmaceutical performed: i.) Wettability test artificial saliva; ii.) Swelling measurement iii.) Measurement adhesion between simulated mucosa surface. All three resulted differentiation materials. The coated showed favorable behavior To vivo, intervention study was conducted. 36 adults included likeliness prolonged (un-)coated capsule same weight objectively evaluated by means magnetic resonance imaging. While capsules highest rates transit, tendency reduced tablets, least i.e., 22.2 %, 11.1 ≤5.6 % cases, respectively. Further not possible. Subjective evaluations each participant subjective did correlate objective measurements coatings general transit. selection type seems be greater importance patients' perception forms probability
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1397 - 1397
Опубликована: Окт. 30, 2024
The global aging population has experienced rapid growth in recent decades, leading to an increased prevalence of psychiatric disorders, particularly depression, among older adults. Depression the geriatric is often compounded by chronic physical conditions and various psychosocial factors, significantly impacting their quality life. main question raised this review as follows: how can personalized medicine age-appropriate therapeutic approaches improve management depression? This paper explores epidemiology highlighting influence gender, race, socioeconomic status on its prevalence. classification diagnosis depressive based ICD-11 DSM-5 criteria, reveal complexity managing these Personalized (PM) emerges a promising approach, focusing tailoring treatments individual's genetic, clinical, environmental characteristics. However, application PM demographic faces challenges, context pharmaceutical forms. need for drug delivery systems critical, given polypharmacy issues such dysphagia patients. study emphasizes importance developing patient-centric formulations enhance effectiveness therapy
Язык: Английский
Процитировано
1
RPS Pharmacy and Pharmacology Reports, Год журнала: 2024, Номер 4(1)
Опубликована: Дек. 13, 2024
Abstract Objectives This study explores the potential of extrusion-based 3D printing to improve medication adherence by developing chocolate-based oral dosage forms incorporating active pharmaceutical ingredients such as paracetamol and ibuprofen while using soy lecithin an emulsifier enhance flow properties chocolate formulation, enabling consistent reliable forms. Methods Extrusion-based was used obtain drug-loaded solid The formulation components well design conditions were optimized, appearance patient acceptability final products. Techniques spectroscopy, thermal analysis, rheology, mechanical in-vitro dissolution employed assess physicochemical these formulations. Key findings Soy essential in obtaining robust formulations showed good stability demonstrated drug release. Conclusions suggest that printing, with aid emulsifiers lecithin, is a viable method for producing personalized, delivery systems, potentially improving through customizable Further research could understanding factors particle size, crystallinity, impact chewing on release optimize therapeutic outcomes.
Язык: Английский
Процитировано
1
International Journal of Pharmaceutics, Год журнала: 2021, Номер 602, С. 120625 - 120625
Опубликована: Апрель 21, 2021
Multidrug dosage forms (aka combination forms, polypills, etc.) create value for patients through reduced pill burdens and simplified administration to improve adherence therapy. Enhanced flexibility of multidrug would provide further opportunities better match emerging needs individualized Through modular form concepts, one approach satisfy these is adapt a wider variety drugs, each with doses release profiles. This study investigates technically explores design requirements extending the capability concepts towards individualization. builds on our recent demonstration independent tailoring dose drug release, which here extended poorly water-soluble drugs. The challenging requirement carrying higher loads in smaller volumes accommodate multiple drugs at their clinical met regarding performance. With concept, we demonstrate high precision (<5% RSD) performance individual modules containing felodipine or naproxen Kollidon VA64 both wide loading range (5% w/w 50% drug) small module size (3.6 mg). In forward-looking design-based discussion, are addressed, emphasizing that reproducible predictive performance, provided designed act independently. Therefore, efforts incorporate progressively within will be crucial extend window full future
Язык: Английский
Процитировано
10
Pharmaceutics, Год журнала: 2021, Номер 13(4), С. 557 - 557
Опубликована: Апрель 15, 2021
Calquence® (crystalline acalabrutinib), a commercially marketed tyrosine kinase inhibitor (TKI), exhibits significantly reduced oral exposure when taken with acid-reducing agents (ARAs) due to the low solubility of weakly basic drug at elevated gastric pH. These drug–drug interactions (DDIs) negatively impact patient treatment and quality life strict dosing regimens required. In this study, plasma high pH was overcome using spray-dried amorphous solid dispersion (ASD) comprising 50% acalabrutinib hydroxypropyl methylcellulose acetate succinate (HPMCAS, H grade) formulated as an immediate-release (IR) tablet. ASD tablets achieved similar area under concentration–time curve (AUC) outperformed Calquence capsules 2.4-fold in beagle dogs. vitro multicompartment dissolution testing conducted priori vivo study successfully predicted improved formulation performance. addition, were 60% smaller than demonstrated good laboratory-scale manufacturability, physical stability, chemical stability. dosage forms are attractive for improving compliance efficacy other drugs that have pH-dependent absorption.
Язык: Английский
Процитировано
7