Recent advances in using liposomes for delivery of nucleic acid-based therapeutics

OpenNano, Год журнала: 2023, Номер 11, С. 100132 - 100132

Опубликована: Фев. 24, 2023

Nucleic acid therapeutics are rapidly expanding because of recent advancements in production and purification. This class may change the field disease treatment personalized medicine since it can cure diseases. However, drug delivery systems crucial for these to fulfill their potential. Liposomes have long been considered ideal platforms systemic drugs delivery. Considering development cancer therapeutics, this work emphases on current liposomes' Nano-formulations, functionalization, design how has applied nucleic therapeutics. Accordingly, review covers literature that deals with liposomes therapy.

Язык: Английский

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Exploring ncRNA-mediated regulation of EGFR signalling in glioblastoma: From mechanisms to therapeutics

Life Sciences, Год журнала: 2024, Номер 345, С. 122613 - 122613

Опубликована: Апрель 4, 2024

Язык: Английский

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Liposome-Based Drug Delivery Systems in Cancer Research: An Analysis of Global Landscape Efforts and Achievements

Pharmaceutics, Год журнала: 2024, Номер 16(3), С. 400 - 400

Опубликована: Март 14, 2024

Lipid-bilayer-based liposomes are gaining attention in scientific research for their versatile role drug delivery. With amphiphilic design, efficiently encapsulate and deliver drugs to targeted sites, offering controlled release. These artificial structures hold great promise advancing cancer therapy methodologies. Bibliometric analyzes systematic literary data statistically. This study used bibliometric indicators examine, map, evaluate the applications of therapy. A Scopus search was conducted identify all English-language peer-reviewed publications on within past twenty years. were calculated using VOSviewer Biblioshiny. We produced thematic, conceptual, visualization charts. total 14,873 published documents obtained. The procedure keyword mapping has effectively identified main areas concentration prevailing trends this specific field study. significant clusters discovered through theme hotspot analyses encompassed many topics such as use multiple strategies chemotherapy different forms cancer, pharmacokinetics nanomedicine, well investigation delivery, cytotoxicity, gene Liposomes employed delivery systems so selectively target cells improve bioavailability anticancer drugs. work showcased capacity tailor these accurate by including potent medications. Our findings not only bring latest progress utilizing treatment but also underscore vital need ongoing research, collaborative efforts, effective translation breakthroughs into tangible clinical applications, emphasizing dynamic evolving nature therapeutics.

Язык: Английский

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Advances in liposome-based delivery of RNA therapeutics for cancer treatment

Progress in molecular biology and translational science, Год журнала: 2024, Номер unknown, С. 177 - 218

Опубликована: Янв. 1, 2024

Язык: Английский

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Current paradigms in employing self-assembled structures: Drug delivery implications with improved therapeutic potential

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 234, С. 113745 - 113745

Опубликована: Янв. 5, 2024

Язык: Английский

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Synthesis, characterization and assessment of anticancer potency of oxcarbazepine with folic acid conjugated Fe2O3 nanostructures as nano-drugs

Journal of Molecular Structure, Год журнала: 2024, Номер 1306, С. 137842 - 137842

Опубликована: Фев. 20, 2024

Язык: Английский

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Variants of SARS-CoV-2: Influences on the Vaccines’ Effectiveness and Possible Strategies to Overcome Their Consequences

Medicina, Год журнала: 2023, Номер 59(3), С. 507 - 507

Опубликована: Март 5, 2023

The immune response elicited by the current COVID-19 vaccinations declines with time, especially among immunocompromised population. Furthermore, emergence of novel SARS-CoV-2 variants, particularly Omicron variant, has raised serious concerns about efficacy currently available vaccines in protecting most vulnerable people. Several studies have reported that vaccinated people get breakthrough infections amid cases. So far, five variants concern (VOCs) been reported, resulting successive waves infection. These shown a variable amount resistance towards neutralising antibodies (nAbs) either through natural infection or vaccination. spike (S) protein, membrane (M) and envelope (E) protein on viral surface N-nucleocapsid core ribonucleoprotein are major structural vaccine target proteins against COVID-19. Among these targets, S Protein extensively exploited to generate effective Hence, SARS-CoV-2, we discussed their impact vaccines. We also potential roles development vaccination approaches contain negative consequences variants’ acquisition mutations SARS-CoV-2. Moreover, implications SARS-CoV-2’s were terms elicit an response.

Язык: Английский

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Field-flow fractionation - an excellent tool for fractionation, isolation and/or purification of biomacromolecules

Journal of Chromatography A, Год журнала: 2023, Номер 1712, С. 464492 - 464492

Опубликована: Ноя. 4, 2023

Field-flow fractionation (FFF) with its several variants, has developed into a mature methodology. The scope of the FFF investigations expanded, covering both wide range basic studies and especially analytical applications. Special attention this review is given to achievements reference recent applications in fractionation, isolation, purification biomacromolecules, from which those (in alphabetical order) bacteria, cells, extracellular vesicles, liposomes, lipoproteins, nucleic acids, viruses virus-like particles. In evaluating major approaches trends demonstrated since 2012, most significant biomacromolecule are compiled tables. It also evident that asymmetrical flow field-flow by far dominant technique studies. industry shown current interest adopted it some sophisticated fields. FFF, combination appropriate detectors, handles biomacromolecules open channel gentle way due lack shear forces unwanted interactions caused stationary phase present chromatography. addition, isolation quite high yields can be achieved under optimal conditions.

Язык: Английский

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Liposomal Drug Delivery: Comparative Kinetics, Efficacy, and Applications in Targeted Therapeutics

Theoretical and Natural Science, Год журнала: 2025, Номер 69(1), С. 140 - 149

Опубликована: Янв. 15, 2025

During the Second World War, in order to reduce infections soldiers wounds, nurses had inject injured with multiple shots of penicillin per day because one single shot only lasts a short period time, but lack human resources prevented some wounded from receiving dose that they needed[1]. To need for labor intake, Romansky discovered mixing lipids would prolong time which has effect. This innovation saved lot people infection at time. Lipid-based drug carriers have been developed and innovated even more throughout years.A few years ago, COVID-19 pandemic facilitated advancements vaccination technologies, including use authorization mRNA vaccines encapsulated lipid nanoparticles. Traditional delivery methods, such as oral injection, transdermal applications, usually face challenges like low accuracy, toxicity, variable effectiveness. However, liposomes, 1960s, emerged carrier that, due their specific structure, allowed prolonged site-specific release. Liposomes can encapsulate drugs different molecular qualities, allowing lipid-based excellent performance carrying both hydrophobic hydrophilic drugs. paper examines composition factors bilayers, release kinetics delivery. Using hybrid modeling approach first-order Higuchi model, study simulates profiles. The liposomal formulation demonstrates potential systems enhancing efficacy while minimizing side effects treatments.

Язык: Английский

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Potential of trehalose and sucrose-raffinose combination instead of sucrose applied to the cytarabine/daunorubicin co-loaded lyophilized liposome: Investigation on the protective effect and mechanism of various lyoprotectants

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 92, С. 105360 - 105360

Опубликована: Янв. 10, 2024

Язык: Английский

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