Impact of COVID-19 on Ocular Surface Health: Infection Mechanisms, Immune Modulation, and Inflammatory Responses
Duliurui Huang,
Weixia Xuan,
Zhijie Li
и другие.
Viruses,
Год журнала:
2025,
Номер
17(1), С. 68 - 68
Опубликована: Янв. 6, 2025
COVID-19,
caused
by
SARS-CoV-2,
has
presented
formidable
challenges
to
global
health
since
its
emergence
in
late
2019.
While
primarily
known
for
respiratory
symptoms,
it
can
also
affect
the
ocular
surface.
This
review
summarizes
effects
of
SARS-CoV-2
on
surface
immunity
and
inflammation,
focusing
infection
mechanisms,
immune
responses,
clinical
manifestations.
Ocular
though
uncommon,
include
conjunctivitis,
dry
eye,
blurred
vision.
binds
ACE2
receptors
epithelial
cells,
facilitating
viral
entry,
replication,
local
dissemination.
The
innate
responses
involving
corneal
cells
are
discussed,
alongside
mechanisms
antigen
presentation
adaptive
immunity.
examines
roles
cytokines
chemokines
mediating
inflammation
explores
impact
cytokine
storms
chronic
health.
Additionally,
interplay
between
systemic
is
highlighted,
analyzing
how
COVID-19
influences
These
insights
underscore
broader
implications
beyond
localized
infection.
By
consolidating
current
findings,
this
aims
guide
preventive
therapeutic
strategies
while
identifying
directions
future
research
mitigate
consequences
COVID-19.
Язык: Английский
Successful salvage of a severe COVID-19 patient previously with lung cancer and radiation pneumonitis by mesenchymal stem cells: a case report and literature review
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 6, 2024
During
the
COVID-19
pandemic,
elderly
patients
with
underlying
condition,
such
as
tumors,
had
poor
prognoses
after
progressing
to
severe
pneumonia
and
often
response
standard
treatment.
Mesenchymal
stem
cells
(MSCs)
may
be
a
promising
treatment
for
pneumonia,
but
MSCs
are
rarely
used
carcinoma.
Here,
we
reported
67-year-old
female
patient
lung
adenocarcinoma
who
underwent
osimertinib
radiotherapy
suffered
from
radiation
pneumonitis.
Unfortunately,
she
contracted
that
rapidly
progressed
pneumonia.
She
responded
poorly
frontline
was
in
danger.
Subsequently,
received
salvage
four
doses
of
MSCs,
her
symptoms
surprisingly
improved
quickly.
After
CT
scan
presented
significantly
infection,
discharged
eventually.
Her
primary
disease
stable
6
months
follow-up,
no
tumor
recurrence
or
progression
observed.
an
effective
hyperactive
inflammation
due
their
ability
related
immunomodulation
tissue
repair.
Our
case
suggests
potential
value
is
unresponsive
conventional
therapy
infection.
However,
unless
situation
urgent,
it
needs
considered
caution
tumors.
The
safety
still
Язык: Английский
Strengths and limitations of SARS-CoV-2 virus-like particle systems
Virology,
Год журнала:
2024,
Номер
601, С. 110285 - 110285
Опубликована: Ноя. 5, 2024
Virus-like
particles
(VLPs)
resemble
the
parent
virus
but
lack
viral
genome,
providing
a
safe
and
efficient
platform
for
analysis
of
assembly
budding
as
well
development
vaccines
drugs.
During
COVID-19
pandemic,
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
formation
SARS-CoV-2
VLPs
was
investigated
an
alternative
to
authentic
virions
because
latter
requires
biosafety
level
3
(BSL-3)
facilities.
This
allowed
researchers
model
its
processes,
examine
role
mutations
in
variants
concern,
determine
how
structural
proteins
interact
with
each
other.
Also,
absence
genome
circumvents
worries
gains
infectivity
via
mutagenesis.
review
summarizes
strengths
limitations
several
VLP
systems
details
some
strides
that
have
been
made
using
these
study
budding,
entry,
antibody
vaccine
development.
Язык: Английский
Coronavirus spike protein-based vaccines. Vaccine delivery systems
Medicine in Drug Discovery,
Год журнала:
2024,
Номер
unknown, С. 100198 - 100198
Опубликована: Сен. 1, 2024
Язык: Английский
Dimming the corona: studying SARS-coronavirus-2 at reduced biocontainment level using replicons and virus-like particles
mBio,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
The
coronavirus-induced
disease
19
(COVID-19)
pandemic,
caused
by
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
infections,
has
had
a
devastating
impact
on
millions
of
lives
globally,
with
mortality
rates
and
catastrophic
social
implications.
Developing
tools
for
effective
vaccine
strategies
platforms
is
essential
controlling
preventing
the
recurrence
such
pandemics.
Moreover,
molecular
virology
that
facilitate
study
viral
pathogens,
mutations,
interactions
various
host
proteins
are
essential.
Viral
replicon-
virus-like
particle
(VLP)-based
systems
excellent
examples
tools.
This
review
outlines
importance,
advantages,
disadvantages
both
VLP-based
have
been
developed
SARS-CoV-2
helped
scientific
community
in
dimming
intensity
COVID-19
pandemic.
Язык: Английский