Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 3 - 33
Опубликована: Янв. 1, 2025
Язык: Английский
Egyptian Liver Journal, Год журнала: 2024, Номер 14(1)
Опубликована: Янв. 2, 2024
Abstract Background Hepatocellular carcinoma (HCC) is a common type of liver cancer, with high mortality rate. cancer that can be effectively managed through early detection and accurate diagnosis, followed by personalized treatment plan may include surgical resection, transplantation, minimally-invasive techniques, immunotherapy, or targeted therapy depending on the stage severity cancer. Main body abstract This paper discusses recent advances in detection, management, prevention HCC. The use newer imaging such as Magnetic resonance (MRI) contrast-enhanced ultrasound, along image segmentation technology deep learning models, have greatly enhanced accuracy HCC diagnosis. Minimally-invasive thermal ablation radiofrequency ablation, allowed for more precise destruction tumors, while Nanoparticles, immunotherapy shown promise management advanced Artificial intelligence (AI) machine has revolutionized research, aiding identification high-risk patients predicting outcomes. Lifestyle modifications, weight alcohol avoidance, hepatitis B vaccinations, play critical role preventing development. Short conclusion Recent improving patient therapy, AI research lifestyle modifications prevention. However, further required to fully understand potential benefits nanoparticles, traditional Chinese medicine herbal medicines treatment. Graphical
Язык: Английский
Процитировано
33
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 6099 - 6126
Опубликована: Июнь 1, 2024
Abstract: The relentless pursuit of effective cancer diagnosis and treatment strategies has led to the rapidly expanding field nanotechnology, with a specific focus on nanocomposites. Nanocomposites, combination nanomaterials diverse properties, have emerged as versatile tools in oncology, offering multifunctional platforms for targeted delivery, imaging, therapeutic interventions. Nanocomposites exhibit great potential early detection accurate imaging diagnosis. Integrating various modalities, such magnetic resonance (MRI), computed tomography (CT), fluorescence into nanocomposites enables development contrast agents enhanced sensitivity specificity. Moreover, functionalizing targeting ligands ensures selective accumulation tumor tissues, facilitating precise diagnostic accuracy. On front, revolutionized by overcoming traditional challenges associated drug delivery. controlled release from nanocomposite carriers enhances bioavailability, reduces systemic toxicity, improves overall efficacy. Additionally, integration stimuli-responsive components within site-specific triggered unique microenvironment tumor. Despite remarkable progress field, biocompatibility, scalability, long-term safety profiles remain. This article provides comprehensive overview recent developments, challenges, prospects, emphasizing transformative revolutionizing landscape diagnostics therapeutics. In Conclusion, integrating heralds new era precision medicine. Keywords: nanocomposites, cancer, diagnosis, therapy, nanoparticles, theranostic
Язык: Английский
Процитировано
19
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 250, С. 114548 - 114548
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
2
Sensors, Год журнала: 2023, Номер 23(24), С. 9842 - 9842
Опубликована: Дек. 15, 2023
Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical challenges due to their invasive nature and limited treatment options. The current therapeutic landscape for gliomas is constrained by "one-size-fits-all" paradigm, significantly restricting efficacy. Despite the implementation multimodal strategies, survival rates remain disheartening. conventional approach, involving surgical resection, radiation, chemotherapy, grapples with substantial limitations, particularly in addressing gliomas. Conventional diagnostic tools, including computed tomography (CT), magnetic resonance imaging (MRI), positron emission (PET), play pivotal roles outlining tumor characteristics. However, they face such as poor biological specificity distinguishing active regions. ongoing development tools approaches represents multifaceted promising frontier battle against this challenging tumor. aim comprehensive review address recent advances These innovations minimize invasiveness while enabling precise, targeting localized Researchers are actively developing new colorimetric techniques, electrochemical biosensors, optical coherence tomography, reflectometric interference spectroscopy, surface-enhanced Raman biosensors. regulate progression develop precise methods Recent technological advancements, coupled bioelectronic sensors, open avenues modalities, minimizing unprecedented precision. next generation strategies holds potential precision medicine, aiding early detection effective management solid tumors. offer promise adopting medicine methodologies, disease detection, improving management. This comprehensively recognizes critical role pioneering interventions, holding significant revolutionize therapeutics.
Язык: Английский
Процитировано
36
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Сен. 27, 2023
Abstract One of the primary goals for researchers is to create a high-quality sensor with simple structure because urgent requirement identify biomolecules at low concentrations diagnose diseases and detect hazardous chemicals health early on. Recently graphene has attracted much interest in field improved biosensors. Meanwhile, new materials such as CaF 2 been widely used improve applications graphene-based sensors. Using fantastic features graphene/CaF multilayer, this article proposes an improvement sensitivity (S), figure merit (FOM), quality factor (Q). The proposed based on five-layers graphene/dielectric grating integrated Fabry–Perot cavity. By tuning chemical potential (µ c ), due semi-metal graphene, surface plasmon resonance (SPR) waves excited boundaries. Due vertical polarization source gratings symmetry electric field, both corners act dipoles, causes propagation plasmonic propagate towards each other. Finally, it (FP) interference structure's active medium (the area where sample located). In article, using inherent nature FP its S environment's refractive index (RI), by changing minimal amount RI sample, wavelength (interferometer order) shifts sharply. design can sense some cancers, Adrenal Gland Cancer, Blood Breast Cancer I, II, Cervical skin cancer precisely. optimizing structure, we achieve high 9000 nm/RIU FOM about 52.14 first order (M 1 ). Likewise, remarkable 38,000 81 have obtained second mode addition, label-free SPR changes concentration various materials, including gases biomolecules, hemoglobin, breast cancer, diabetes, leukemia, most alloys, accuracy 0.001. urine maximum 8500 cancers 6000 range 7000 nm/RIU. Also, four viruses, M13 bacteriophage, HIV type one, Herpes simplex 1, influenza, investigated, showing Maximum (for λ R ) 8000 (λ = 11.2 µm), 12,000 10.73 11.78 10.6 respectively, )) mentioned viruses are 4740 8.7 8010 8.44 8100 10.15 8.36 respectively.
Язык: Английский
Процитировано
26
Langmuir, Год журнала: 2024, Номер 40(33), С. 17239 - 17269
Опубликована: Авг. 12, 2024
Nanotechnology has opened new doors of exploration, particularly in materials science and healthcare. Magnetic nanoparticles (MNP), the tiny magnets, because their various properties, have potential to bring about radical changes field medicine. The distinctive surface chemistry, nontoxicity, biocompatibility, and, particular, inducible magnetic moment attracted a great deal interest morphological structures from variety scientific domains. This review presents concise overview MNPs crucial properties synthesis routes. It also aims highlight continuous methods available for MNP production. In recent years, use computational understanding behavior been on rise. Thus, we discuss numerical models developed understand how can be used hyperthermia targeting Circle Wilis. With increasing biomedical applications, it becomes necessary mechanisms toxicity, which are elucidated this review. focuses applications drug delivery, theranostics, MRI contrasting agents. We anticipate that article will broaden perspective help functionality applicability better.
Язык: Английский
Процитировано
11
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2809 - 2809
Опубликована: Фев. 28, 2024
This review focuses on the latest advancements in magnetic hydroxyapatite (mHA) nanoparticles and their potential applications nanomedicine regenerative medicine. mHA have gained significant interest over last few years for great potential, offering advanced multi-therapeutic strategies because of biocompatibility, bioactivity, unique physicochemical features, enabling on-demand activation control. The most relevant synthetic methods to obtain apatite-based materials, either form iron-doped HA showing intrinsic properties or composite/hybrid compounds between superparamagnetic metal oxide nanoparticles, are described as highlighting structure–property correlations. Following this, this discusses application various nanomaterials bone regeneration nanomedicine. Finally, novel perspectives investigated with respect ability improve nanocarriers homogeneous structures promote multifunctional biological applications, such cell stimulation instruction, antimicrobial activity, drug release triggering.
Язык: Английский
Процитировано
10
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 265, С. 130747 - 130747
Опубликована: Март 12, 2024
Язык: Английский
Процитировано
10
Heliyon, Год журнала: 2024, Номер 10(6), С. e27692 - e27692
Опубликована: Март 1, 2024
Nanotheranostics, especially those employing biomimetic approaches, are of substantial interest for molecular imaging and cancer therapy. The incorporation diagnostics therapeutics, known as theranostics, represents a promising strategy in modern oncology. Biomimetics, inspired by nature, offers multidisciplinary avenue with potential advancing theranostics. This review comprehensively analyses recent progress biomimetics-based emphasizing its role overcoming current treatment challenges, focus on breast, prostate, skin cancers. Biomimetic approaches have been explored to address multidrug resistance (MDR), their immunotherapy photothermal specific areas covered include drug delivery systems bypassing MDR mechanisms, platforms immune checkpoint blockade, cell modulation, tumor ablation. Pretargeting techniques enhancing radiotherapeutic agent uptake discussed, along comprehensive clinical trials global nanotheranostics. delves into materials, nanotechnology, bioinspired strategies imaging, diagnosis, targeted delivery. These probes, contrast agents, biosensors enhanced specificity sensitivity. involve the design nanoparticles, liposomes, hydrogels site-specific improved therapeutic efficacy. Overall, this provides valuable information investigators, clinicians, biomedical engineers, offering insights latest biomimetics applications Leveraging aims revolutionize treatment, patient outcomes.
Язык: Английский
Процитировано
9
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104701 - 104701
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1