Enhanced Intracellular Delivery of Curcumin Using Polymeric Nanocarriers: A Natural Photosensitizing Agent for Anti-Cancer Photodynamic Therapy

Journal of Fluorescence, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Язык: Английский

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Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature Review

Applied Sciences, Год журнала: 2025, Номер 15(7), С. 3516 - 3516

Опубликована: Март 23, 2025

This research explored the potential of plant antimicrobial compounds as natural alternatives to synthetic antimicrobials in food and pharmaceutical industries, emphasizing urgent need combat resistance. It detailed various mechanisms by which these plant-derived inhibit microbial growth, including disrupting cell membrane integrity, impeding wall protein synthesis, preventing biofilm formation, ultimately leading bacterial death. study highlighted specific effects on cells, such inhibiting cellular respiration, motility, while also modulating oxygen consumption reactive species generation, are vital addressing biofilm-mediated infections. Additionally, can regulate expression virulence factors efflux pumps, enhancing antibiotic efficacy. A bibliometric analysis revealed a growing trend output international collaboration, particularly from China United States, with key journals “Frontiers Microbiology” “Antimicrobial Agents Chemotherapy.” The identified six clusters related research, underscoring for further investigation into applications bioactive compounds. In conclusion, understanding action is important their effective application combating

Язык: Английский

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Emerging phytochemical-based nanocarriers: redefining the perspectives of breast cancer therapy

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Язык: Английский

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Untargeted Metabolomics Reveals Acylcarnitines as Major Metabolic Targets of Resveratrol in Breast Cancer Cells

Metabolites, Год журнала: 2025, Номер 15(4), С. 250 - 250

Опубликована: Апрель 5, 2025

Background/Objectives: Millions of new diagnoses breast cancer are made each year, with many cases having poor prognoses and limited treatment options, particularly for some subtypes such as triple-negative cancer. Resveratrol, a naturally occurring polyphenol, has demonstrated anticancer properties in studies. However, the mechanism action this compound remains elusive, although prior evidence suggests that may work through altering cell metabolism. Our objective current study was to perform untargeted metabolomics analysis on resveratrol-treated cells identify key metabolic targets compound. Methods: MCF-7 MDA-MB-231 were treated varying doses resveratrol extracted mass spectrometry-based metabolomics. Data preprocessing filtering data from samples yielded 4751 peaks, 312 peaks matched an in-house standards library 3459 public databases. Results: Pathway MetaboAnalyst identified significant (p < 0.05) pathways affected by treatment, those involving steroid, fatty acid, amino nucleotide Evaluation standard-matched revealed acylcarnitines major target long-chain exhibiting 2–5-fold increase 5–13-fold when comparing 100 µM vehicle-treated 0.05, VIP > 1). Notably, below 10 showed opposite effect, possibly indicating biphasic effect due switch anti-oxidant pro-oxidant effects dose levels increase. Conclusions: These findings suggest induces mitochondrial reprogramming dose-dependent manner. The response indicates potential optimal dosage therapeutic effectiveness. Further research is warranted explore mechanisms underlying these alterations their implications precision nutrition strategies treatment.

Язык: Английский

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Nanoparticulate drug delivery systems for colonic disorders

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 317 - 344

Опубликована: Янв. 1, 2024

Язык: Английский

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