Recent advances and clinical translation of liposomal delivery systems in cancer therapy

European Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 193, С. 106688 - 106688

Опубликована: Янв. 1, 2024

The limitations of conventional cancer treatment are driving the emergence and development nanomedicines. Research in liposomal nanomedicine for therapy is rapidly increasing, opening up new horizons treatment. Liposomal nanomedicine, which focuses on targeted drug delivery to improve therapeutic effect while reducing damage normal tissues cells, has great potential field therapy. This review aims clarify advantages systems We describe recent understanding spatiotemporal fate liposomes organism after different routes administration. Meanwhile, various types liposome-based that exert their respective side effects were discussed. Moreover, combination agents with other therapies (such as photodynamic photothermal therapy) demonstrated enhanced tumor-targeting efficiency efficacy. Finally, opportunities challenges faced by liposome nanoformulations entering clinical highlighted.

Язык: Английский

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A Comprehensive Review of Nanoparticles: From Classification to Application and Toxicity

Molecules, Год журнала: 2024, Номер 29(15), С. 3482 - 3482

Опубликована: Июль 25, 2024

Nanoparticles are structures that possess unique properties with high surface area-to-volume ratio. Their small size, up to 100 nm, and potential for modifications have enabled their use in a wide range of applications. Various factors influence the applications NPs, including synthesis method physical attributes such as size shape. Additionally, materials used NPs primary determinants application. Based on chosen material, generally classified into three categories: organic, inorganic, carbon-based. These categories include variety materials, proteins, polymers, metal ions, lipids derivatives, magnetic minerals, so on. Each material possesses activity application NPs. Consequently, certain typically particular areas because they higher efficiency along tenable toxicity. Therefore, classification base NP hold significant importance both research In this paper, we discuss these classifications, exemplify most major categorize them according preferred area This review provides an overall application,

Язык: Английский

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Nanostructured lipid carriers as a drug delivery system: A comprehensive review with therapeutic applications

Intelligent Pharmacy, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential

Results in Chemistry, Год журнала: 2025, Номер unknown, С. 102068 - 102068

Опубликована: Янв. 1, 2025

Язык: Английский

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Lipidic and Inorganic Nanoparticles for Targeted Glioblastoma Multiforme Therapy: Advances and Strategies

Micro, Год журнала: 2025, Номер 5(1), С. 2 - 2

Опубликована: Янв. 3, 2025

Due to their biocompatibility, nontoxicity, and surface conjugation properties, nanomaterials are effective nanocarriers capable of encapsulating chemotherapeutic drugs facilitating targeted delivery across the blood–brain barrier (BBB). Although research on nanoparticles for brain cancer treatment is still in its early stages, these systems hold great potential revolutionize drug delivery. Glioblastoma multiforme (GBM) one most common lethal tumors, heterogeneous aggressive nature complicates current treatments, which primarily rely surgery. One significant obstacles poor penetration BBB. Moreover, GBM often referred as a “cold” tumor, characterized by an immunosuppressive tumor microenvironment (TME) minimal immune cell infiltration, limits effectiveness immunotherapies. Therefore, developing novel, more treatments critical improving survival rate patients. Current strategies enhancing outcomes focus controlled, agents cells BBB using nanoparticles. These therapies must be designed engage specialized transport systems, allowing efficient penetration, improved therapeutic efficacy, reduced systemic toxicity degradation. Lipid inorganic can enhance while minimizing side effects. formulations may include epitopes—small antigen fragments that bind directly free antibodies, B receptors, or T receptors—that interact with enable crossing, thereby boosting efficacy. Lipid-based (LNPs), such liposomes, niosomes, solid lipid (SLNs), nanostructured carriers (NLCs), among promising due unique including size, modification capabilities, proven biosafety. Additionally, gold nanoparticles, mesoporous silica, superparamagnetic iron oxide dendrimers offer alternatives. Inorganic (INPs) easily engineered, surfaces modified various elements biological ligands delivery, biocompatibility. Strategies engineering functionalization have been employed ensure biocompatibility reduce cytotoxicity, making safer clinical applications. The use INPs has shown promise efficacy traditional like chemotherapy, radiotherapy, gene therapy, well advancing newer strategies, immunotherapy, photothermal photodynamic therapies, magnetic hyperthermia. This article reviews latest treating GBM, focusing active passive targeting approaches.

Язык: Английский

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Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review

Biomolecules, Год журнала: 2025, Номер 15(1), С. 88 - 88

Опубликована: Янв. 9, 2025

One class of cosmetic compounds that have raised interest many experts is peptides. The search for ingredients with good biocompatibility and bioactivity has led to the use peptides in products. Peptides are novel active improve collagen synthesis, enhance skin cell proliferation, or decrease inflammation. Based on their mechanism action, they can be classified into signal peptides, carrier neurotransmitter inhibitor enzyme This review focuses main types application field, underlining limitations. most significant drawbacks poor permeability through membranes, which limits delivery effectiveness. As a result, this follows methods used improving stratum corneum. Increasing peptide bioavailability stability enhanced desired site action visible effects become central points latest research due promising features. For purpose, several been identified described. Physical techniques include thermal ablation (radiofrequency laser), electrical (electroporation, iontophoresis), mechanical approach (microneedles), ultrasounds. an alternative, innovative formulations developed nano-systems such as liposomes, niosomes, ethosomes, nanoemulsions, other nanomaterials reduce irritation product purpose provide information regarding these noteworthy molecules reasoning behind formulations.

Язык: Английский

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Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 397(5), С. 2793 - 2833

Опубликована: Ноя. 22, 2023

Язык: Английский

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Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management

Pharmaceutics, Год журнала: 2023, Номер 16(1), С. 58 - 58

Опубликована: Дек. 29, 2023

Alzheimer's disease, a progressive neurodegenerative condition, is characterized by gradual decline in cognitive functions. Current treatment approaches primarily involve the administration of medications through oral, parenteral, and transdermal routes, aiming to improve function alleviate symptoms. However, these treatments face limitations, such as low bioavailability inadequate permeation. Alternative invasive methods, while explored, often entail discomfort require specialized assistance. Therefore, development non-invasive efficient delivery system crucial. Intranasal has emerged potential solution, although it constrained unique conditions nasal cavity. An innovative approach involves use nano-carriers based on nanotechnology for intranasal delivery. This strategy overcome current limitations providing enhanced bioavailability, improved permeation, effective traversal blood-brain barrier, extended retention within body, precise targeting brain. The comprehensive review focuses advancements designing various types nano-carriers, including polymeric nanoparticles, metal lipid liposomes, nanoemulsions, Quantum dots, dendrimers. These are specifically tailored therapeutic agents aimed at combatting disease. In summary, utilization systems show significant surmounting constraints disease strategies. Nevertheless, essential acknowledge regulatory well toxicity concerns associated with this route; meticulous consideration required when engineering carrier. underscores revolutionize management highlights importance addressing considerations safe implementations. Embracing could lead substantial field treatment.

Язык: Английский

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Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route

Journal of Nanotechnology, Год журнала: 2023, Номер 2023, С. 1 - 35

Опубликована: Ноя. 6, 2023

Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid-induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain primary hiccups effective of medications. With advent nanotechnology, nanostructured lipid carriers (NLCs) have emerged as a promising carrier that can circumvent gastrointestinal tract (GIT) barriers hindering solubility bioavailability such These NLCs efficiently transport drug moieties across intestinal membranes shielding medications from pH degradation. Because they are composed lipidic materials, be easily absorbed or taken up by various pathways transcellular absorption, paracellular transport, M-cell uptake. Such mechanisms not only improve absorption drugs but also augment residence time may bypass first-pass metabolism. This review explores diverse applications in medical conditions, shedding light on their current regulatory status, including FDA-approved options those pre/clinical stages. The features patented NLC formulations. It provides valuable insights into how harnessed outlines recent advancements optimizing performance to tackle barriers, thus opening new possibilities future pharmaceutical applications.

Язык: Английский

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A Review: Surface Engineering of Lipid‐Based Drug Delivery Systems

Small, Год журнала: 2024, Номер 20(43)

Опубликована: Июль 14, 2024

This review explores the evolution of lipid-based nanoparticles (LBNPs) for drug delivery (DD). Herein, LBNPs are classified into liposomes and cell membrane-based (CMNPs), each with unique advantages challenges. Conventional possess drawbacks such as poor targeting, quick clearance, limited biocompatibility. One possible alternatives to overcome these challenges is surface modification (NPs) materials polyethylene glycol (PEG), aptamers, antibody fragments, peptides, CD44, hyaluronic acid, folic palmitic lactoferrin. Thus, main focus this will be on different modifications that enable have beneficial properties DD, enhancing mass transport properties, immune evasion, improved stability, targeting. Moreover, various CMNPs explored used DD derived from cells red blood (RBCs), platelets, leukocytes, cancer cells, stem highlighting their natural (e.g., biocompatibility ability evade system). discussion extends biomimicking hybrid NPs accomplished through coating synthetic (mainly polymeric) membranes. aims provide a comprehensive resource researchers recent advances in field CMNPs. Overall, provides valuable insights dynamic systems.

Язык: Английский

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