Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 179 - 226
Опубликована: Ноя. 29, 2024
Язык: Английский
Frontiers in Biomaterials Science, Год журнала: 2025, Номер 4
Опубликована: Фев. 12, 2025
Immunotherapy has emerged as a powerful approach in treating various diseases, yet its success often hinges on the efficacy of adjuvants, agents that boost immune responses to therapeutic targets. Traditional adjuvants have offered foundational support but may fall short achieving specificity and potency required for advanced therapies. This review highlights new generation poised address these limitations. We explore range innovative agents, including non-inflammatory nucleic acid bacterial derivatives, synthetic molecules, which are redefining role immunotherapy. These emerging hold promise enhancing while tailoring therapies specific disease contexts, from cancer infectious diseases. By examining applications potential this aims provide comprehensive understanding how they can advance immunotherapy levels precision. Through development novel stands achieve more targeted sustained impacts, paving way improved outcomes patient care.
Язык: Английский
Процитировано
0
Опубликована: Апрель 15, 2024
The growing use of adjuvants in the fast-paced formulation new vaccines has created an unprecedented need for meaningful analytical assays that deliver reliable quantitative data from complex adjuvant and adjuvant-antigen mixtures. Due to their chemical physical properties, method development separation vaccine is considered a highly challenging laborious task. Reversed-phase liquid chromatography (RPLC) among most important tests (bio)pharmaceutical industry release stability indicating measurements including content, identity, purity profile. However, time constraints developing “on-demand” robust methods prior each change can easily lead sample analysis becoming bottleneck development. Herein simple efficient generic framework capable chromatographically resolving commonly used non-aluminum based across academic industrial sectors introduced. This was designed seek more proactive approach assay endeavors evolved extensive stationary phase screening conjunction with multifactorial silico simulations retention (RT) as function gradient time, temperature, organic modifier blending, buffer concentration. models yield 3D resolution maps excellent baseline all single run, which found be very accurate, differences between experimental simulated times less than 1%. described here also includes introduction versatile by introducing dynamic RT database covering entire library broad mechanisms action numerous formulations linearity, accuracy, precision, specificity. power this demonstrated generated rapidly guiding processes formulations. Analytical work covers profile RPLC-UV-CAD, component identification (RPLC-MS) formulations, surfactants (e.g., polysorbates), well targets.
Язык: Английский
Процитировано
1
ACS Pharmacology & Translational Science, Год журнала: 2024, Номер 7(10), С. 3108 - 3118
Опубликована: Сен. 11, 2024
The growing use of adjuvants in the fast-paced formulation new vaccines has created an unprecedented need for meaningful analytical assays that deliver reliable quantitative data from complex adjuvant and adjuvant-antigen mixtures. Due to their chemical physical properties, method development separation vaccine is considered a highly challenging laborious task. Reversed-phase liquid chromatography (RPLC) among most important tests (bio)pharmaceutical industry release stability indicating measurements including content, identity, purity profile. However, time constraints developing "on-demand" robust methods prior each change can easily lead sample analysis becoming bottleneck development. Herein, simple efficient generic framework capable chromatographically resolving commonly used non-aluminum-based across academic industrial sectors introduced. This was designed seek more proactive approach assay endeavors evolved extensive stationary phase screening conjunction with multifactorial
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(19), С. 10520 - 10520
Опубликована: Сен. 29, 2024
Inhalation allergies caused by cats and dogs can lead to a range of discomforting symptoms, such as rhinitis asthma, in humans. With the increasing popularity care provided these companion animals, allergens they produce pose growing threat susceptible patients’ health. Allergens from have emerged significant risk factors for triggering asthma allergic worldwide; however, there remains lack systematic measures aimed at assisting individuals recognizing preventing animals. This review provides comprehensive insights into classification cat dog allergens, along with their pathogenic mechanisms. study also discusses implementation strategies prevention control measures, including physical methods, gene-editing technology, immunological approaches, well potential enhancing allergen immunotherapy combined immunoinformatics. Finally, it presents future prospects treatment human dogs. will improve knowledge regarding while providing targets development next-generation treatments.
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 179 - 226
Опубликована: Ноя. 29, 2024
Язык: Английский
Процитировано
0