Engineering sodium alginate microparticles with different crystallinities for niclosamide repositioning and solubilization to improve solubility and oral bioavailability in rats
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
283, С. 137471 - 137471
Опубликована: Ноя. 9, 2024
Язык: Английский
ANOCTAMIN PHARMACOLOGY
Cell Calcium,
Год журнала:
2024,
Номер
121, С. 102905 - 102905
Опубликована: Май 10, 2024
Язык: Английский
Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation
Cell & Bioscience,
Год журнала:
2024,
Номер
14(1)
Опубликована: Апрель 27, 2024
Abstract
Background
Extensive
hepatocyte
mortality
and
the
absence
of
specific
medical
therapy
significantly
contribute
to
unfavorable
prognosis
acute
liver
failure
(ALF).
Ferroptosis
is
a
crucial
form
cell
death
involved
in
ALF.
In
this
study,
we
aimed
determine
impact
Mediator
complex
subunit
1
(Med1)
on
ferroptosis
its
potential
hepatoprotective
effects
Results
Med1
expression
diminished
lipopolysaccharide
(LPS)/D-galactosamine
(D-GalN)-induced
ALF
mice,
as
well
hepatocytes
damaged
by
H
2
O
or
TNF-α/D-GalN
vitro.
overexpression
mitigates
injury
decreases
rate
mice
inhibition.
The
mechanism
which
inhibits
erastin-induced
involves
upregulation
nuclear
factor
erythroid
2-related
(Nrf2)
downstream
antioxidant
genes
heme
oxygenase-1
(HO-1),
glutamate
cysteine
ligase
catalytic
(GCLC),
NAD(P)H
quinone
oxidoreductase
(NQO1).
Furthermore,
suppresses
transcription
proinflammatory
cytokines
tumor
necrosis
factor-α
(TNF-α)
interleukin-6
(IL-6)
with
LPS/D-GalN-induced
Conclusion
Overall,
our
research
findings
indicate
that
alleviates
through
activation
Nrf2.
These
substantiate
therapeutic
viability
targeting
Med1-Nrf2
axis
means
treating
individuals
afflicted
Graphical
Язык: Английский
Targeting both ferroptosis and pyroptosis may represent potential therapies for acute liver failure
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
30(33), С. 3791 - 3798
Опубликована: Авг. 30, 2024
In
this
editorial,
we
comment
on
the
article
published
in
recent
issue
of
Язык: Английский
Drug Repurposing: Research Progress of Niclosamide and Its Derivatives on Antibacterial Activity
Infection and Drug Resistance,
Год журнала:
2024,
Номер
Volume 17, С. 4539 - 4556
Опубликована: Окт. 1, 2024
The
development
of
antibiotic
resistance
complicates
the
treatment
infectious
diseases
and
is
a
global
public
health
threat.
However,
drug
repurposing
can
address
this
issue
reduce
research
costs.
Niclosamide
salicylanilide
compound
approved
by
Food
Drug
Administration
(FDA),
it
has
been
used
clinically
for
treating
parasitic
infections
many
years.
Recent
studies
have
shown
that
niclosamide
inhibit
bacterial
fungus
activity
affecting
quorum
sensing
system,
biofilm
formation,
cell
membrane
potential,
other
mechanisms.
Here,
we
discuss
recent
advances
in
antimicrobial
applications
its
derivatives
to
provide
new
perspectives
diseases.
Язык: Английский