Journal of Ocular Pharmacology and Therapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 2, 2024
Benzalkonium
chloride
(BAK)
is
a
commonly
used
preservative
to
maintain
sterility
for
multiuse
eye
drops
such
as
latanoprost.
One
option
minimize
the
deleterious
effects
of
BAK
in
may
be
reduce
volume
administered.
The
aim
this
study
was
assess
response
cells
from
ocular
surface
latanoprost+BAK
administered
by
Optejet
technology,
which
dispenses
microdose
(∼8
µL)
ophthalmical
spray.
Hardware,
Год журнала:
2024,
Номер
2(1), С. 1 - 32
Опубликована: Янв. 26, 2024
Three-dimensional
(3D)
printing
is
a
process
in
which
materials
are
added
together
layer-by-layer
manner
to
construct
customized
products.
Many
different
techniques
of
3D
exist,
vary
used,
cost,
advantages,
and
drawbacks.
Medicine
increasingly
benefiting
from
this
transformative
technology,
the
field
ophthalmology
no
exception.
The
possible
applications
eyecare
vast
have
been
explored
literature,
such
as
3D-printed
ocular
prosthetics,
orbital
implants,
educational
anatomical
models,
well
surgical
planning
training.
Novel
drug-delivery
platforms
also
emerged
because
printing,
offering
improved
treatment
modalities
for
several
pathologies.
Innovative
research
bioprinting
viable
tissues,
including
cornea,
retina,
conjunctiva,
presenting
an
avenue
regenerative
ophthalmic
therapies
future.
Although
further
development
capabilities
suitable
required,
represents
powerful
tool
enhancing
eye
health.
Biomaterials Science,
Год журнала:
2024,
Номер
12(10), С. 2504 - 2520
Опубликована: Янв. 1, 2024
In
recent
years,
the
design
and
synthesis
of
Janus
hydrogels
have
witnessed
a
thriving
development,
overcoming
limitations
single-performance
materials
expanding
their
potential
applications
in
tissue
engineering
regenerative
medicine.
hydrogels,
with
exceptional
mechanical
properties
excellent
biocompatibility,
emerged
as
promising
candidates
for
various
biomedical
applications,
including
therapies.
this
review,
we
present
latest
progress
using
commonly
employed
preparation
methods.
We
elucidate
surface
interface
interactions
these
discuss
enhanced
bestowed
by
unique
"Janus"
structure
biomaterials.
Additionally,
explore
facilitating
therapies,
such
drug
delivery,
wound
healing,
engineering,
biosensing.
Furthermore,
analyze
challenges
future
trends
associated
utilization
applications.
The
special
structure
of
eyes
and
the
existence
various
physiological
barriers
make
ocular
drug
delivery
one
most
difficult
problems
in
pharmaceutical
field.
Considering
patient
compliance,
local
administration
remains
preferred
method
anterior
part
eyes.
However,
suffers
from
poor
bioavailability,
need
for
frequent
administration,
systemic
toxicity.
Administration
posterior
eye
is
more
difficult,
intravitreal
injection
often
used.
But
faces
compliance
likely
side
effects
after
multiple
injections.
development
nanocarrier
technology
provides
an
effective
way
to
solve
these
problems.
Among
them,
liposomes,
as
widely
used
carrier
clinical
application,
have
characteristics
amphiphilic
nanostructure,
easy
surface
modification,
extended
release
time,
good
biocompatibility,
etc.
liposomes
are
expected
overcome
obstacles
effectively
deliver
drugs
target
site
improve
bioavailability.
This
review
summarized
controllable
properties
well
application
research
progress
diseases.
In
addition,
we
routes
contained
eyes,
prospects
treatment
Abstract
In
recent
years,
nanomaterials
have
demonstrated
broad
prospects
in
the
diagnosis
and
treatment
of
retinal
diseases
due
to
their
unique
physicochemical
properties,
such
as
small‐size
effects,
high
biocompatibility,
functional
surfaces.
Retinal
are
often
accompanied
by
complex
pathological
microenvironments,
where
conventional
diagnostic
therapeutic
approaches
face
challenges
low
drug
delivery
efficiency,
risks
associated
with
invasive
procedures,
difficulties
real‐time
monitoring.
Nanomaterials
hold
promise
addressing
these
limitations
traditional
therapies,
thereby
improving
precision
efficacy.
The
applications
diagnostics
summarized,
they
enable
high‐resolution
imaging
carrying
fluorescent
probes
or
contrast
agents
act
biosensors
sensitively
detect
disease‐related
biomarkers,
facilitating
early
dynamic
therapeutics,
functionalized
nanocarriers
can
precisely
deliver
drugs,
genes,
antioxidant
molecules
target
cells,
significantly
enhancing
outcomes
while
reducing
systemic
toxicity.
Additionally,
nanofiber
materials
possess
properties
that
make
them
particularly
suitable
for
regeneration
tissue
engineering.
By
loading
neurotrophic
factors
into
scaffolds,
regenerative
effects
be
amplified,
promoting
repair
neurons.
Despite
immense
potential,
clinical
translation
still
requires
long‐term
biosafety,
scalable
manufacturing
processes,
optimization
targeting
efficiency.
Research Journal of Pharmacy and Technology,
Год журнала:
2025,
Номер
unknown, С. 537 - 544
Опубликована: Фев. 27, 2025
Keratitis
left
untreated
can
lead
to
blindness.
Various
factors
contribute
ocular
keratitis,
primarily
viral
infections
such
as
VZV
and
HSV.
Ganciclovir
is
effective
in
treating
keratitis
by
inhibiting
DNA
polymerase
replication,
thereby
suppressing
reproduction
delaying
the
progression
of
disease,
which
ultimately
reduces
risk
corneal
scarring
perforation.
However,
efficacy
ganciclovir
limited
challenges
related
medication
delivery
absorption,
particularly
with
conventional
eye
drops
ointments
that
quickly
evaporate
upon
contact
cornea,
necessitating
frequent
administration
may
impact
patient
compliance.
To
overcome
these
limitations,
researchers
have
explored
nanoparticle-based
drug
systems.
Nanoparticles,
those
made
from
biocompatible
biodegradable
materials
like
ethyl
cellulose,
offer
advantages
controlled
release,
enhanced
bioavailability,
improved
permeability.
Ethyl
cellulose
nanoparticles
effectively
transport
drugs
tissues,
protect
them
degradation,
improve
reducing
frequency
dosing
minimizing
side
effects.
In
this
study,
was
incorporated
into
using
emulsion-solvent
evaporation
method.
The
formulation
parameters,
including
polyvinyl
alcohol
concentrations,
were
optimized
a
32
full
factorial
design.
(B6)
demonstrated
lowest
errors
had
particle
size,
zeta
potential,
encapsulation
efficiency
values
178.1nm,
-21.53mV,
53.51%,
respectively.
Furthermore,
batch
exhibited
sustained
87.14%
release
observed
at
12
hours.
Overall,
study
highlights
potential
promising
system
for
improving
treatment
outcomes
showing
favorable
characteristics
delivery.
Macromolecular Bioscience,
Год журнала:
2024,
Номер
24(4)
Опубликована: Янв. 12, 2024
Osteoporotic
bone
defects
cannot
withstand
surgery
with
more
significant
trauma
due
to
fragility,
while
systemic
drug
therapy
has
formidable
adverse
effects.
Consequently,
the
present
study
introduces
an
innovatively
devised
injectable
double-crosslinked
hydrogel,
as
a
potential
therapeutic
avenue
for
addressing
varied
shapes
of
osteoporotic
via
minimally
invasive
approach.
The
hydrogel
is
formed
by
formation
Schiff
base
bonds
between
oxidized
sodium
alginate
(OSA)
and
carboxymethyl
chitosan,
polymerization
gelatin
methacrylate
UV
light
crosslinking.
Additionally,
alendronate
(ALN)
loaded
into
through
OSA,
nanohydroxyapatite
(nHA)
incorporated
blending.
demonstrates
excellent
injectability,
nHA
improves
mechanical
properties
can
promote
formation.
In
addition,
sustain
release
ALN,
which
effect
inhibiting
osteoclasts.
Cell
studies
indicate
that
differentiation
osteoblasts
inhibit
activity
osteoclast,
so
obtain
better
osteogenic
effect.
Therefore,
be
used
repair
invasive,
simple
treatment
modality.
Deleted Journal,
Год журнала:
2024,
Номер
01(02), С. 101 - 113
Опубликована: Март 4, 2024
mRNA
therapeutics
have
garnered
significant
attention
in
the
biomedical
realm,
showing
immense
potential
across
a
spectrum
of
applications
from
COVID-19
to
cancer
treatments.Their
ability
trigger
precise
protein
expression,
particularly
genome
editing,
is
pivotal
minimizing
off-target
effects.At
core
therapy
lies
dual-component
system,
comprising
itself
and
delivery
vehicle.The
breakthrough
success
novel
vaccines
has
catapulted
lipid
nanoparticles
prominence
as
preferred
vehicle.However,
despite
their
US
FDA
approval
efficacy,
face
challenge:
poor
stability
at
room
temperature,
which
limits
various
geographic
regions
with
disparities
infrastructure
technology.This
review
aims
dissect
issue
inherent
other
platforms
such
polymer-based
materials
derivative
materials.We
herein
endeavor
unravel
factors
contributing
instability
explore
strategies
enhance
stability.By
doing
so,
we
provide
comprehensive
analysis
current
landscape
systems,
highlighting
both
successes
limitations,
paving
way
for
future
advancements
this
rapidly
evolving
field.
