Targeted Drug Delivery System for Pulmonary Fibrosis: Design and Development of Biomaterials

BIO Integration, Год журнала: 2025, Номер 6(1)

Опубликована: Янв. 1, 2025

Pulmonary fibrosis (PF) is a progressive interstitial lung disease characterized by excessive extracellular matrix deposition and tissue scarring, leading to impaired function respiratory failure. Although current treatments, such as pirfenidone nintedanib, slow progression, they fail completely halt or reverse fibrosis. Therefore, innovative therapeutic strategies are needed. Targeted drug delivery systems (TDDSs) emerging promising solutions. Biomaterials play critical roles in these enhancing specificity, availability, efficacy, while minimizing systemic toxicity. The most notable biomaterials include nanotechnology-based systems, including liposomes polymeric nanoparticles, which facilitate penetration release fibrotic tissues. Hydrogels have three-dimensional structures providing controlled sustained at inflammation sites, therefore particularly valuable PF treatment. Furthermore, biological carriers stem cells vesicles biocompatibility anti-inflammatory effects that improve outcomes. Despite the potential of clinical translation hindered several challenges, immune clearance, stability platforms, optimization retention within diseased Interdisciplinary approaches integrating precision medicine with advancements may provide solutions opening new avenues for This review discusses developments targeted PF, emphasizing importance biomaterials, mechanisms barriers involved pulmonary delivery, future perspectives overcoming limitations. ultimate goal patient outcomes revolutionizing approach treatment through advanced technologies.

Язык: Английский

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Emerging Trends and Translational Challenges in Drug and Vaccine Delivery

Pharmaceutics, Год журнала: 2024, Номер 16(1), С. 98 - 98

Опубликована: Янв. 11, 2024

Drug and vaccine delivery have received considerable attention in recent years [...]

Язык: Английский

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Overview of Venous Thromboembolism and Emerging Therapeutic Technologies Based on Nanocarriers-Mediated Drug Delivery Systems

Molecules, Год журнала: 2024, Номер 29(20), С. 4883 - 4883

Опубликована: Окт. 15, 2024

Venous thromboembolism (VTE) is a serious health condition and represents an important cause of morbidity and, in some cases, mortality due to the lack effective treatment options. According Centers for Disease Control Prevention, 3 out 10 people with VTE will have recurrence clotting event within ten years, presenting significant unmet medical need. For patients, symptoms can last longer higher than average risk complications; contrast, others may experience complications arising from insufficient therapies. People are initially treated anticoagulants prevent conditions such as stroke reduce VTE. However, thrombolytic therapy used pulmonary embolism (PE) experiencing low blood pressure or severe cases DVT. New drugs under development, aim ensure they safe effective, provide additional option In this review, we summarize all ongoing trials evaluating anticoagulant interventions listed clinicaltrials.gov, clarifying their underlying mechanisms whether progression DVT PE thrombosis. Moreover, review summarizes available evidence that supports use antiplatelet Since agents would off-target effects, targeted drug delivery platforms develop various therapeutics thrombotic diseases. We discuss recent advances achieved thrombus-targeting nanocarriers well major challenges associated nanoparticle-based therapeutics.

Язык: Английский

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Nanotechnological advancement for the treatment of neurodegenerative disorders

Journal of Dispersion Science and Technology, Год журнала: 2024, Номер unknown, С. 1 - 19

Опубликована: Ноя. 25, 2024

Язык: Английский

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Editorial: Insights in red blood cell physiology: 2023

Frontiers in Physiology, Год журнала: 2024, Номер 15

Опубликована: Июнь 5, 2024

Keywords: sickle cell disease, drug transport, asplenia, transfusion, extracellular vesicle release, GP.Mur, COVID-19, hemorheology

Язык: Английский

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Small extracellular vesicles derived from mesenchymal stem/stromal cells as drug-delivery tools for anti-cancer drugs

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105999 - 105999

Опубликована: Июль 27, 2024

Язык: Английский

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Bioinspired and bioderived nanomedicine for inflammatory bowel disease

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2024, Номер 16(4)

Опубликована: Июль 1, 2024

Due to its chronic nature and complex pathophysiology, inflammatory bowel disease (IBD) poses significant challenges for treatment. The long-term therapies patients, often diagnosed between the ages of 20 40, call innovative strategies target inflammation, minimize systemic drug exposure, improve patients' therapeutic outcomes. Among plethora currently pursued, bioinspired bioderived nano-based formulations have garnered interest their safety versatility in management IBD. Bioinspired nanomedicine can host deliver not only small molecules but also biotherapeutics, be made gastroresistant mucoadhesive or mucopenetrating and, these reasons, are largely investigated oral administration, while surprisingly less rectal delivery, recommended first-line treatment approach several IBD patients. use nanocarriers, mostly extracellular vesicles (EVs), endowed with unique homing abilities, is still infancy respect arsenal under investigation An emerging source EVs suited administration ingesta, that is, plants milk, thanks remarkable ability resist harsh environment upper gastrointestinal tract. Inspired by unparalleled properties natural biomaterials, sophisticated avenues enhancing efficacy advancing precision medicine approaches care taking shape, although bottlenecks arising either from complexity designed lack a clear regulatory pathway hinder smooth efficient translation clinics. This article categorized under: Nanotechnology Approaches Biology > Nanoscale Systems Biology.

Язык: Английский

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Biomedical Applications of Magnetically Functionalized Nanoparticles

Опубликована: Янв. 1, 2024

Язык: Английский

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Nano-encapsulated CRISPR-based genome: Next-generation strategies to optimize delivery

IP International Journal of Comprehensive and Advanced Pharmacology, Год журнала: 2024, Номер 9(4), С. 219 - 220

Опубликована: Ноя. 15, 2024

Nano-encapsulated CRISPR-based genome: Next-generation strategies to optimize delivery - IJCAAP- Print ISSN No: 2581-5555 Online No:- 2456-9542 Article DOI 10.18231/j.ijcaap.2024.032, IP International Journal of Comprehensive and Advanced Pharmacology-IP Int J Compr Adv Pharmacol

Язык: Английский

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