ACS symposium series,
Год журнала:
2024,
Номер
unknown, С. 235 - 257
Опубликована: Ноя. 1, 2024
Wounds
are
a
significant
healthcare
issue
affecting
millions
of
people
globally.
Effective
wound
management
is
challenging
due
to
the
complications
involved
in
healing
process.
Biopolymers,
which
naturally
sourced
biomolecules
derived
from
plants,
microbes,
and
animals,
exhibit
high
level
biocompatibility.
The
bioactive
characteristics
these
polymers
include
immune-modulatory,
antimicrobial,
angiogenic,
cell-proliferative
qualities,
providing
an
optimal
environment
for
healing.
In
addition
traditional
care
methods,
biopolymers
becoming
integral
component
treatment
excellent
biodegradability,
biocompatibility,
similarity
macromolecules
human
body.
This
chapter
discusses
process,
assessment
principles,
use
biopolymers,
such
as
alginate,
chitosan,
cellulose,
collagen,
hyaluronic
acid,
materials.
European Journal of Medicinal Chemistry Reports,
Год журнала:
2024,
Номер
12, С. 100184 - 100184
Опубликована: Июнь 26, 2024
Polyphenol
is
a
versatile
green
phytochemical
vital
in
several
biomedical
applications
with
fascinating
inherent
biocompatible,
bioadhesive,
antioxidant,
and
antibacterial
properties.
The
emergence
of
novel
nanotechnology
techniques,
such
as
electrospinning,
has
proven
to
be
an
excellent
option
for
nanotechnology,
ensuring
effective
drug
delivery
system
recognised
medicinal
plant
extracts
containing
polyphenols
electrospun
nanofibers
can
provide
the
necessary
environment
encapsulation.
Together,
have
shown
promising
usage
wound
healing.
When
are
incorporated
into
nanofibrous
scaffolds,
their
combined
properties
enhance
cell
attachment,
proliferation,
differentiation.
This
review
explores
potential
polyphenol-loaded
therapy,
highlighting
importance
efficient
systems
polyphenols.
It
provides
brief
assessment
specific
(resveratrol,
curcumin,
thymol,
quercetin,
tannic
acid,
ferulic
hesperidin,
gallic
kaempferol,
chlorogenic
acid)
that
been
successfully
encapsulated
applied
treatment.
Despite
ongoing
research,
certain
carvacrol,
oleuropein,
kaempferol
remain
less
explored.
underscores
need
continued
investigation
these
while
recognising
growing
application
healing
more
extensive
therapeutic
use.
Antibiotic
resistance
is
a
significant
threat
to
public
health
and
drug
development,
driven
largely
by
the
overuse
misuse
of
antibiotics
in
medical
agricultural
settings.
As
bacteria
adapt
evade
current
drugs,
managing
bacterial
infections
has
become
increasingly
challenging,
leading
prolonged
illnesses,
higher
healthcare
costs,
increased
mortality.
This
review
explores
critical
role
fighting
mechanisms
that
enable
resist
them.
Key
discussed
include
carvacrol,
dalbavancin,
quinolones,
fluoroquinolones,
zoliflodacin,
each
with
unique
actions
against
pathogens.
Bacteria
have
evolved
complex
strategies,
such
as
enzyme
production
neutralize
modifying
targets,
using
efflux
pumps
remove
antibiotics,
significantly
reducing
efficacy.
Additionally,
examines
challenges
antibiotic
including
declining
discovery
rate
novel
drugs
due
high
costs
regulatory
complexities.
Innovative
approaches,
structure-based
design,
combination
therapies,
new
delivery
systems,
are
highlighted
for
their
potential
create
compounds
enhanced
action
resistant
strains.
provides
valuable
insights
researchers
developers
aiming
combat
advance
development
robust
antibacterial
therapies
future
security.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101538 - 101538
Опубликована: Фев. 8, 2025
Diabetic
wounds
are
a
major
clinical
challenge
due
to
their
chronic,
non-healing
nature,
which
significantly
impacts
patients'
quality
of
life.
Traditional
treatments
often
fail
effectively
promote
wound
healing,
highlighting
the
need
for
new
biomaterials.
In
this
study,
we
developed
composite
hydrogel
(KC@PF@TA)
that
combines
photothermal
and
antibacterial
properties
Ti₃C₂Tx-Ag
(Titanium
carbide-silver)
with
regenerative
effects
paeoniflorin
(PF).
The
was
optimized
by
adjusting
composition,
crosslinking
density,
incorporation
nanoparticles,
enhanced
its
mechanical
strength,
conversion
efficiency,
properties,
biocompatibility.
demonstrated
cell
proliferation,
migration,
robust
in
vitro.
diabetic
murine
model
Staphylococcus
aureus-infected
wounds,
KC@PF@TA
exhibited
exceptional
therapeutic
benefits
antibacterial,
anti-inflammatory,
angiogenic,
tissue
regeneration.
Overall,
our
results
suggest
hydrogels
controlled
bioactive
agent
release
modulation
present
promising
solution
treating
chronic
wounds.
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Abstract
There
is
intense
research
during
the
past
few
decades
to
design
and
fabricate
drug
delivery
systems
using
electrospinning
system.
Electrospinning
an
efficient
technique
produce
nanofiber
materials
with
different
dimensions
morphologies
by
adjusting
processing
parameters.
becoming
innovative
technology
that
promotes
pursuit
maintenance
of
human
health.
Herein,
review
discusses
contribution
in
systems,
summarising
modification
various
system
configurations
effects
process
parameters
on
fibers,
their
application
including
carrier
materials,
loaded
drugs
release
mechanisms
illustrates
medical
applications.
Finally,
this
challenges,
bottlenecks,
development
prospects
field
terms
scaling
up
for
clinical
use
exploring
potential
solutions
pave
way
establish
future
systems.
Journal of Biomedical Materials Research Part A,
Год журнала:
2025,
Номер
113(3)
Опубликована: Март 1, 2025
Maintaining
precise
control
over
fiber
alignment
during
the
electrospinning
process
is
a
significant
challenge
in
material
science.
Various
techniques
have
been
explored
to
enhance
alignment,
including
use
of
rotating
collectors,
patterned
electrodes,
and
magnetic
fields.
However,
these
methods
are
typically
complex,
expensive,
involve
multiple
procedural
steps,
which
can
hinder
their
practical
application
industrial
settings.
In
this
work,
polycaprolactone
(PCL)
was
used
electrospun
scaffolds
characterized
by
meshed,
aligned,
grid
structures.
A
cost-effective
approach
for
fabricating
fibers,
offering
enhanced
scaffold,
potentially
beneficial
medical
applications
developed
study.
Using
previously
fabricated
aligned
fibers
served
as
foundation
developing
ocular
contact
lenses
incorporating
newly
designed
meshed
fibers.
comparative
proof-of-concept
study
conducted,
utilizing
three
distinct
orientations
evaluate
efficacy
potential
drug
delivery
each
type
within
scaffolds.
The
morphology,
light
transmittance,
mechanical
properties,
wettability
were
systematically
assessed.
PCL-based
lenses,
specifically
tailored
conform
anatomical
shape
eye,
demonstrated
extension
Rhodamine
B
residence
time,
achieving
an
increase
up
two
hours
compared
conventional
eye
drops
on
porcine
cornea.
Among
types
analyzed,
emerged
most
promising,
followed
both
exhibiting
superior
retention
conclusion,
innovative
advancements
PCL
fabrication
underscore
applications.
