pH-Responsive Co-Assembled Peptide Hydrogel to Inhibit Drug-Resistant Bacterial Infection and Promote Wound Healing

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(15), С. 18400 - 18410

Опубликована: Апрель 5, 2024

Drug-resistant bacterial infection and biofilm formation are the key inhibitors of wound healing, new strategies urgently needed to address these issues. In this study, we designed a pH-responsive co-assembled peptide hydrogel inhibit Methicillin-resistant Staphylococcus aureus (MRSA) promote healing. We synthesized cationic short (Nap-FFKKK) with curcumin at pH ∼ 7.8. The loaded was continuously released in weak acid environment (pH 5.5). lysine-rich inhibited MRSA via electrostatic interaction negatively charged cell surface and, thus, provided reinforcing antibacterial effect curcumin. vitro experiments showed that system considerably reduced minimum inhibitory concentration against by 10-fold promoted healing mouse model MRSA-infected wounds. This study provides simple promising strategy treat drug-resistant infections

Язык: Английский

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Sodium alginate-based nanofibers loaded with Capparis Sepiaria plant extract for wound healing

Journal of Biomaterials Science Polymer Edition, Год журнала: 2024, Номер 35(15), С. 2380 - 2401

Опубликована: Июль 22, 2024

Burn wounds are associated with infections, drug resistance, allergic reactions, odour, bleeding, excess exudates, and scars, requiring prolonged hospital stay. It is crucial to develop wound dressings that can effectively combat reactions inhibit absorb exudates accelerate healing. To overcome the above-mentioned problems burn wounds, SA/PVA/PLGA/Capparis sepiaria SA/PVA/Capparis nanofibers incorporated Capparis plant extract were prepared using an electrospinning technique. Fourier-transform infrared spectroscopy confirmed successful incorporation of into without any interaction between polymers. The displayed porous morphology a rough surface suitable for cellular adhesion proliferation. demonstrated significant antibacterial effects against infection-associated bacterial strains: Pseudomonas aeruginosa, Enterococcus faecalis, Mycobaterium smegmatis, Escherichia coli, Enterobacter cloacae, Proteus vulgaris, Staphylococcus aureus. Cytocompatibility studies HaCaT cells revealed non-toxicity nanofibers. exhibited hemostatic properties, resulting from synergistic effect in vitro scratch healing assay showed nanofiber wound-healing capability more than commercially available dressing. potential attributed phytochemicals present extract, their porosity, ECM-mimicking structure findings suggest electrospun loaded promising should be explored wounds.

Язык: Английский

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Biosynthesized ZnO nanoparticle-functionalized fabrics for antibacterial and biocompatibility evaluations in medical applications: A critical review

Materials Today Chemistry, Год журнала: 2024, Номер 42, С. 102421 - 102421

Опубликована: Ноя. 26, 2024

Язык: Английский

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Nanomedicine and Its Role in Surgical Wound Infections: A Practical Approach

Bioengineering, Год журнала: 2025, Номер 12(2), С. 137 - 137

Опубликована: Янв. 31, 2025

Surgical wound infections are a major cause of postoperative complications, contributing to surgical morbidity and mortality. With the rise antibiotic-resistant pathogens, it is crucial develop new innovative materials manage using methods that facilitate drug delivery agents rely on other than antimicrobials. Nanoparticles, in particular, have captured researchers' interest recent years due their effectiveness care. They can be classified into three main types: inorganic nanoparticles, lipid-based polymeric nanoparticles. Several studies demonstrated these technologies enhancing wound-healing times reducing bacterial burden. However, further research essential thoroughly evaluate safety toxicity before they integrated routine practice.

Язык: Английский

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Nanoimprinted Materials for Nanoparticle Sensing and Removal

Nanomaterials, Год журнала: 2025, Номер 15(3), С. 243 - 243

Опубликована: Фев. 5, 2025

The booming expansion of nanotechnology poses the problem environmental pollution by nanoparticles (NPs). available methods for sensing and removing NPs from environment are typically lengthy instrumentally demanding. recent introduction NP-imprinted polymers (NPIPs), either as films or bulk materials, is an important step toward simple fast removal water air. Similarly to well-established molecularly imprinted polymers, in NPIPs, organic inorganic polymeric material first obtained with embedded NPs. Then, chemically physically removed acting a template, i.e., leaving matrix cavities same shape dimensions. After examples were published 2014, literature has so far reported increasing number NPIPs that capable reuptaking (or, more rarely, air), remarkable size selectivity. By laying NPIP layer on reporter (typically electrode), devices On other hand, can reuptake massive amounts have been used quantitative water. This review begins overview hollow capsules, which be considered ancestors both conception preparative methods. reviewed. Finally, possible evolutions highlighted perspective stepping their real-life, field use.

Язык: Английский

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Conferring NiTi alloy with controllable antibacterial activity and enhanced corrosion resistance by exploiting Ag@PDA films as a platform through a one-pot construction route

Heliyon, Год журнала: 2024, Номер 10(14), С. e34154 - e34154

Опубликована: Июль 1, 2024

The lack of antibacterial activity and the leaching Ni ions seriously limit potential applications near equiatomic nickel-titanium (NiTi) alloy in biomedical field. In this study, a silver nanoparticles (Ag NPs) wrapped polydopamine (Ag@PDA) film modified NiTi with controllable enhanced corrosion resistance was achieved using one-pot approach mixed solution AgNO3 dopamine. could be by adjusting initial concentration dopamine (Cdop), which obtained Ag@PDA films varying thickness layers coated on Ag NPs, thereby conferring different levels to alloy. vitro ratios (24 h) film-modified against E.coli S.aureus ranged from 46 % 100 42 %, respectively. release curves indicated persistent effect for at least 21 days. Moreover, cytotoxicity vivo implantation tests demonstrated satisfactory biosafety when used as bioimplants. This research offers valuable insight into meeting various demands implantations highlights Ag-containing biomaterials addressing types infections induced implantations.

Язык: Английский

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A Review of Recent Advancements and Perspectives of Nanotechnology in the Application of Biomedical Imaging and Instrumentation

ChemistrySelect, Год журнала: 2024, Номер 9(27)

Опубликована: Июль 12, 2024

Abstract The development of imaging, diagnosis, prognosis and early detection diseases has been greatly impacted by nanotechnology enhancing already existing clinically applicable technologies. With the help their capacity to alter nanoparticles for molecular‐level specificity, tissue‐specific diagnosis is made possible gratitude unique biophysical features that enable contrast augmentation will boost biomedical imaging. prospect multiplexing fact minute changes in nanoparticles’ size or composition can have significant effects on optical, magnetic, electrical capabilities. This article examines nanotechnology's function In this article, fundamentals applications pharmaceutical application microbial surfactants, intelligent drug delivery systems, green metallic nanoparticle manufacturing are all examined. comprising organic (carbon nanotubes, metal oxide liposomes) inorganic (metal oxide, metal) nanoparticles, materials with nanopatterns diagnostics, biosensing, bioimaging devices, along main topics discussion. studies conducted vitro vivo demonstrated different be utilized detect seizures precisely treat them successfully. To decrease toxicity improved target respectively, more synthesis functionalization adaptable nanotechnologies required.

Язык: Английский

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Bioactive Curcuma aromatica-stabilized silver nanoparticles embedded chitosan dressing with improved antibacterial, anti-inflammatory, and wound healing properties

Carbohydrate Polymer Technologies and Applications, Год журнала: 2024, Номер unknown, С. 100570 - 100570

Опубликована: Сен. 1, 2024

Язык: Английский

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LysSYL‐Loaded pH‐Switchable Self‐Assembling Peptide Hydrogels Promote Methicillin‐Resistant Staphylococcus Aureus Elimination and Wound Healing

Advanced Materials, Год журнала: 2024, Номер 36(52)

Опубликована: Ноя. 16, 2024

Abstract Staphylococcus aureus ( S. ), especially methicillin‐resistant (MRSA), causes wound infections, whose treatment remains a clinical challenge. Bacterium‐infected wounds often create acidic niches with pH 4.5–6.5. Endolysin LysSYL, which is derived from phage SYL, shows promise as an antistaphylococcal agent. However, endolysins generally exhibit instability and possess low bioavailability in microenvironments. Here, array of self‐assembling peptides designed, peptide L5 screened out based on its gel formation property bioavailability. exerted pH‐switchable antimicrobial effect (pH 5.5) formed biocompatible hydrogels at neutral 7.4). The LysSYL‐loaded can assemble L5@LysSYL hydrogels, increase thermal stability, the slow‐release LysSYL. Effective elimination achieved by through bacterial membrane disruption cell separation inhibition. Moreover, great potential promoting healing mouse model infected MRSA. Furthermore, are safe decrease cytokine levels number key factors for vessel formation, contribute to healing. Overall, effectively clean MRSA promote healing, suggests pH‐sensitive dressing management infections.

Язык: Английский

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Advances in polymer-based scaffolding for enhanced wound healing: a comprehensive review

International Journal of Polymeric Materials, Год журнала: 2024, Номер unknown, С. 1 - 19

Опубликована: Июль 1, 2024

A wound is an immediate injury caused by a forceful impact, trauma, or internal resulting in the rupture of epidermis. Pathophysiological lesions can be classified as acute chronic depending upon time their occurrence. Historically, dressings have been employed method treating both and lesions. These form physical barrier between external environment, thus preventing bacterial infections. However, absence regular dressing changes increases likelihood infection. As result dressing's prior adhesion to incision, its removal cause unwarranted discomfort granule tissue loss. Moreover, other approaches used conventionally are relatively less effective. limitations prompted investigation substitutes that could reduce granulation loss, alleviate pain, deliver adequate oxygen facilitate repair. Scaffolding potentially effective strategy treatment incisions. Various naturally occurring synthetic polymers being explored for purpose. The objective this review provide concise overview physiochemical properties biomedical applications prevailing derived skin regeneration healing, along with various fabrication techniques scaffolds.

Язык: Английский

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