International Journal of Applied Pharmaceutics,
Год журнала:
2024,
Номер
unknown, С. 182 - 189
Опубликована: Ноя. 7, 2024
Objective:
The
purpose
of
this
study
was
to
fabricate
a
dissolving
microneedle
patch
using
3D-printed
master
and
characterize
it
various
techniques.
Methods:
Dissolving
patches
were
developed
Computer-Aided
Design
(CAD)
software
3D
printing.
Polydimethylsiloxane
(PDMS)
reverse
molds
cast
from
the
masters
filled
with
solution
20%
Chitosan
Oligosaccharide
(COS)
Polyvinyl
Alcohol
(PVA).
dried
at
room
temperature
characterized
Scanning
Electron
Microscopy
(SEM),
Attenuated
Total
Reflectance-Fourier
Transform
Infrared
Spectroscopy
(ATR-FTIR),
X-ray
diffraction
(XRD),
Thermogravimetric
Analysis
(TGA),
Differential
Calorimetry
(DSC),
in
vitro
skin
penetration
studies.
Results:
Optical
microscopy
SEM
images
showed
formation
uniform
microneedle.
peak
1248
cm⁻¹
ATR-FTIR
spectrum
indicates
cross-links
between
certain
PVA
radical
groups
COS.
XRD
revealed
that
both
polymers
blended
well
partial
crystallinity,
peaks
2θ
=
11.39°,
20°,
41°.
DSC
TGA
analyses
blend
could
withstand
high
temperatures
good
stability
up
200
°C.
In
studies
confirmed
microneedles
successfully
penetrate
skin,
indicating
their
potential
for
effective
transdermal
drug
delivery.
Conclusion:
This
demonstrated
COS/PVA
fabricated
printing
micro-molding
have
significant
Polymers,
Год журнала:
2024,
Номер
16(10), С. 1396 - 1396
Опубликована: Май 14, 2024
Transdermal
transport
can
be
challenging
due
to
the
difficulty
in
diffusing
active
substances
through
outermost
layer
of
epidermis,
as
primary
function
skin
is
protect
against
entry
exogenous
compounds
into
body.
In
addition,
penetration
epidermis
for
hydrophilic
nature
and
particles
larger
than
500
Da
highly
limited
physiological
properties
non-polar
its
layer,
namely
stratum
corneum.
A
solution
this
problem
use
microneedles,
which
“bypass”
problematic
epidermal
by
dispensing
substance
directly
deeper
layers
skin.
Microneedles
obtained
with
various
materials
come
different
types.
Of
special
interest
are
carriers
based
on
biodegradable
biocompatible
polymers,
such
polysaccharides.
Therefore,
paper
reviews
latest
literature
methods
obtain
hyaluronic
acid-based
microneedles.
It
focuses
current
advancements
field
consequently
provides
an
opportunity
guide
future
research
area.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 10, 2025
Transdermal
drug
delivery
presents
a
promising
noninvasive
approach,
bypassing
first-pass
metabolism
and
gastrointestinal
degradation.
However,
the
stratum
corneum
(SC)
barrier
limits
absorption,
necessitating
development
of
effective
systems.
Microneedles,
particularly
polymer-based
ones,
offer
solution
by
penetrating
SC
while
avoiding
critical
nerves
capillaries.
These
microneedles
are
biodegradable,
nontoxic,
easily
manufacturable,
making
them
highly
attractive
platform
for
transdermal
delivery.
their
clinical
application
remains
limited
due
to
suboptimal
therapeutic
efficacy
slow
release
rates.
Recent
advancements
have
introduced
incorporation
nanodrugs,
such
as
nanoparticles
encapsulated
drugs,
into
enhance
efficiency.
Among
materials
explored,
graphene
its
derivatives,
including
oxide
(GO)
reduced
(rGO),
garnered
significant
attention.
Their
exceptional
mechanical
strength,
electrical
conductivity,
antibacterial
properties
not
only
improve
performance
but
also
rates
biocompatibility.
This
review
synthesizes
current
state
microneedle
technologies,
focusing
on
materials,
fabrication
techniques,
challenges.
It
examines
potential
graphene-based
microneedles,
comparing
traditional
in
terms
efficiency
stability.
The
highlights
key
challenges,
scalability,
biocompatibility,
complexity,
suggests
future
research
directions
address
these
issues.
quantum
dots
(GQDs)
is
identified
avenue
improving
profiles,
stability,
real-time
tracking
diffusion.
Finally,
outlines
emerging
applications,
smart
systems,
biosensing,
monitoring,
urging
further
exploration
unlock
full
graphene-enhanced
settings.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июль 13, 2024
Three-dimensional
(3D)
printing
serves
as
an
alternative
method
for
fabricating
microneedle
(MN)
patches
with
a
high
object
resolution.
In
this
investigation,
four
distinct
needle
shapes:
pyramid
mounted
over
long
cube
(shape
A),
cone
cylinder
B),
pyramidal
shape
C),
and
conical
D)
were
designed
using
computer-aided
design
(CAD)
software
compensated
bases
of
350,
450
550
µm.
Polylactic
acid
(PLA)
biophotopolymer
resin
from
eSun
stereolithography
(SLA)
3D
printer
Anycubic
technology
used
to
print
MN
patches.
The
3D-printed
employed
construct
molds,
those
molds
produce
hydroxypropyl
methylcellulose
(HPMC)
polyvinyl
pyrrolidone
(PVP)
K90
dissolving
microneedles
(DMNs).
Various
parameters,
such
curing
time,
angle,
anti-aliasing
(AA),
varied
evaluate
suitable
conditions
each
shape.
Furthermore,
physical
appearance,
mechanical
property,
skin
insertion
ability
HPMC/PVP
DMNs
examined.
results
showed
that
A
C,
the
time
angle
1.5
s
30°
while
shapes
B
D,
they
2.0
45°,
respectively.
All
required
AA
eliminate
their
stair-stepped
edges.
Additionally,
it
was
demonstrated
all
twelve
designs
could
be
molds.
needles
exhibited
better
physicochemical
properties
compared
C
D.
Particularly,
both
sample
9
10
displayed
sharp
without
bent
tips,
coupled
minimal
height
reduction
(<
10%)
percentage
blue
dots
(approximately
100%).
As
result,
can
utilized
custom
producing
manufactured
by
excellent
properties.
Materials,
Год журнала:
2025,
Номер
18(7), С. 1580 - 1580
Опубликована: Март 31, 2025
Fungal
infections
pose
a
significant
global
health
problem,
affecting
20–25%
of
the
population
and
contributing
to
over
3.75
million
deaths
annually.
Clotrimazole
(CLO)
is
widely
used
topical
antifungal
drug,
but
its
efficacy
limited
by
poor
penetration
through
stratum
corneum.
Microneedle
(MN)
systems,
composed
micron-scale
structures
arranged
on
patch,
offer
promising
strategy
overcome
outermost
skin
barrier
enhance
drug
into
deeper
layers.
However,
optimizing
MN
design,
particularly
in
terms
size,
shape,
fabrication
technology,
essential
for
efficient
delivery.
This
study
aimed
develop
CLO-coated
systems
using
an
Liquid
Crystal
Display
(LCD)-based
3D
printing
technique
thin-film
dip-coating
method.
A
comprehensive
optimization
parameters,
including
anti-aliasing,
layer
thickness,
curing
time,
angle,
was
conducted
ensure
desired
mechanical
properties.
The
optimized
MNs
were
coated
with
either
suspension
or
ethanol-based
CLO-hydrogels,
ethanol
hydrogel
demonstrating
superior
characteristics.
Additionally,
investigated
how
microneedle
geometry
coating
formulation
influenced
release.
Antifungal
activity
against
reference
clinical
origin
Candida
albicans
strains
varied
significantly
depending
formulation.
Finally,
acute
toxicity
test
confirmed
no
toxic
effects
Aliivibrio
fischeri,
indicating
potential
biocompatibility
safety
developed
MN-based
delivery
system.
Molecules,
Год журнала:
2025,
Номер
30(4), С. 883 - 883
Опубликована: Фев. 14, 2025
The
ever-increasing
global
energy
demand
necessitates
the
development
of
efficient,
sustainable,
and
high-performance
storage
systems.
Nanotechnology,
through
manipulation
materials
at
nanoscale,
offers
significant
potential
for
enhancing
performance
devices
due
to
unique
properties
such
as
increased
surface
area
improved
conductivity.
This
review
paper
investigates
crucial
role
nanotechnology
in
advancing
technologies,
with
a
specific
focus
on
capacitors
batteries,
including
lithium-ion,
sodium-sulfur,
redox
flow.
We
explore
diverse
applications
nanomaterials
encompassing
electrode
(e.g.,
carbon
nanotubes,
metal
oxides),
electrolytes,
separators.
To
address
challenges
like
interfacial
side
reactions,
advanced
nanostructured
are
being
developed.
also
delve
into
various
manufacturing
methods
nanomaterials,
top-down
ball
milling),
bottom-up
chemical
vapor
deposition),
hybrid
approaches,
highlighting
their
scalability
considerations.
While
cost-effectiveness
environmental
concerns
persist,
outlook
remains
promising,
emerging
trends
solid-state
batteries
integration
artificial
intelligence
optimized
storage.
Technologies,
Год журнала:
2025,
Номер
13(3), С. 94 - 94
Опубликована: Март 1, 2025
This
paper
presents
a
comprehensive
review
of
quality
control
(QC)
and
reliability
research
in
micro–nano
technology,
which
is
vital
for
advancing
microelectronics,
biomedical
engineering,
manufacturing.
Micro-
nanotechnologies
operate
at
different
scales,
yet
both
require
precise
to
ensure
the
performance
durability
small-scale
systems.
synthesizes
key
methodologies,
including
statistical
methods,
machine
learning
AI-driven
advanced
techniques
emphasizing
their
relevance
nanotechnology
applications.
The
also
discusses
application
micro/nanotechnology
other
technological
areas.
discussion
extends
unique
challenges
posed
by
systems,
such
as
failure
modes
related
stiction,
material
fatigue,
environmental
factors.
Advanced
testing
modeling
approaches
are
highlighted
effectiveness
predicting
mitigating
risks.
Additionally,
explores
integration
emerging
technologies
enhance
improve
By
examining
established
novel
techniques,
this
underscores
evolving
nature
field.
It
identifies
areas
future
investigation,
particularly
adaptation
these
methods
increasing
complexity
concludes
proposing
directions
that
can
further
optimize
continued
advancement
industrial
technologies.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 352 - 352
Опубликована: Март 9, 2025
Pharmaceutical
3D
printing,
combined
with
nanomaterials
and
nanodevices,
presents
a
transformative
approach
to
precision
medicine
for
treating
neurological
diseases.
This
technology
enables
the
creation
of
tailored
dosage
forms
controlled
release
profiles,
enhancing
drug
delivery
across
blood−brain
barrier
(BBB).
The
integration
nanoparticles,
such
as
poly
lactic-co-glycolic
acid
(PLGA),
chitosan,
metallic
nanomaterials,
into
3D-printed
scaffolds
improves
treatment
efficacy
by
providing
targeted
prolonged
release.
Recent
advances
have
demonstrated
potential
these
systems
in
conditions
like
Parkinson’s
disease,
epilepsy,
brain
tumors.
Moreover,
printing
allows
multi-drug
combinations
personalized
formulations
that
adapt
individual
patient
needs.
Novel
approaches,
including
stimuli-responsive
systems,
on-demand
dosing,
theragnostics,
provide
new
possibilities
real-time
monitoring
disorders.
Despite
innovations,
challenges
remain
terms
scalability,
regulatory
approval,
long-term
safety.
future
perspectives
this
suggest
its
revolutionize
treatments
offering
patient-specific
therapies,
improved
penetration,
enhanced
outcomes.
review
discusses
current
state,
applications,
nanotechnology
treatment,
highlighting
need
further
research
overcome
existing
challenges.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 390 - 390
Опубликована: Март 19, 2025
Three-dimensional
printing
technology
is
transforming
pharmaceutical
manufacturing
by
shifting
from
conventional
mass
production
to
additive
manufacturing,
with
a
strong
emphasis
on
personalized
medicine.
The
integration
of
bioinks
and
AI-driven
optimization
further
enhancing
this
innovation,
enabling
drug
precise
dosages,
tailored
drug-release
profiles,
unique
multi-drug
combinations
that
respond
individual
patient
needs.
This
advancement
significantly
impacting
healthcare
accelerating
development,
encouraging
innovative
designs,
treatment
efficacy.
Traditional
follows
one-size-fits-all
approach,
which
often
fails
meet
the
specific
requirements
patients
medical
conditions.
In
contrast,
3D
printing,
coupled
bioink
formulations,
allows
for
on-demand
production,
reducing
dependency
large-scale
storage.
AI-powered
design
process
refine
dosage
forms,
printability,
release
mechanisms,
ensuring
precision
efficiency
in
manufacturing.
These
advancements
have
potential
lower
overall
costs
while
improving
adherence
medication
regimens.
review
explores
potential,
challenges,
environmental
benefits
positioning
it
as
key
driver
next-generation
