Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1369 - 1369
Опубликована: Окт. 25, 2024
: Investigating how nanoparticle systems interact in whole blood (WB) is critical to evaluating the effectiveness of malaria therapy. Methods: We decided establish a pharmacokinetic/pharmacodynamic (PK/PD) model quinine population WB using
Язык: Английский
Advanced Composites and Hybrid Materials, Год журнала: 2025, Номер 8(2)
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
5
Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 67 - 67
Опубликована: Янв. 6, 2025
A comprehensive review of recent research on niosomes was conducted using a mixed methodology, including searches in databases such as Scopus, PubMed, and Web Science (WoS). Articles were selected based relevance. The current examines the historical development focusing methods preparations contemporary strategies prospective advancements within realm drug delivery systems, highlighting innovative approaches across transdermal, oral, cellular delivery. This reported method new novel approach for preparation known ball milling (BM). technique allows precise manipulation size shape, leading to improvements release, encapsulation efficiency, uniformity compared traditional methods. Niosomes can serve carriers delivering various types drugs, hydrophobic, hydrophilic, amphiphilic. improves efficiency encapsulating different targeted particles, desired zeta potential. is achieved by specific charge-inducing agent targeting diseases. These efforts are crucial overcoming limitations unlocking full therapeutic potential modern medicine.
Язык: Английский
Процитировано
4
Food Chemistry, Год журнала: 2025, Номер unknown, С. 144047 - 144047
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
2
Journal of Materials Science Materials in Medicine, Год журнала: 2025, Номер 36(1)
Опубликована: Март 5, 2025
Oral drug administration is the preferred route for pharmaceuticals, accounting ~90% of global pharmaceutical market due to its convenience and cost-effectiveness. This study provides a comprehensive scientific technological analysis latest advances in oral dosage forms colon-targeted delivery. Utilizing patent databases, along with bibliometric bibliographical review, we compared (technology) specific application technology (colon delivery) using four search equations. Our findings reveal gap publications inventions associated colon release general applications. While tablets capsules were found most used forms, other platforms such as nanoparticles, microparticles, emulsions have been also explored. Enteric coatings are frequently applied excipient prevent early stomach pH-triggered systems being predominant mechanism. In summary, this review last advancements high-impact resources development delivery, providing insights into maturity these approaches.
Язык: Английский
Процитировано
1
International Microbiology, Год журнала: 2024, Номер unknown
Опубликована: Авг. 9, 2024
Язык: Английский
Процитировано
4
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 465 - 507
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Science Advances, Год журнала: 2025, Номер 11(20)
Опубликована: Май 14, 2025
Plant cells represent smart cargo carriers with great socioeconomic potential in oral drug delivery applications. The two exterior barriers, featuring a rigid cell wall and dense plasma membrane, are unique complementary structural, mechanical, chemical properties. Current strategies for producing therapeutic drugs within plant efficient, but largely limited to recombinant pharmaceutical proteins, involve complex genetic modification of plants. To address this, we engineer cell–inspired systems cellulose nanofiber–based shells lipid layers through bottom-up assembly strategy, which offers greater flexibility encapsulate nonprotein compounds nanoparticles. Notably, the layered shell structure resists degradation acidic environments, barriers respond differently external stimuli simulated gastrointestinal medium, resulting size-dependent dual-triggered release mechanisms. cytocompatibility was shown by incubation Caco-2 cells. Our results open avenues developing next generation bioinspired multisite-specific low-cost sustainable manner.
Язык: Английский
Процитировано
0
Discover Nano, Год журнала: 2025, Номер 20(1)
Опубликована: Фев. 17, 2025
This present study carried out a systematic review and meta-analysis of peptide nanoparticles in diabetes management for improved patient outcomes from 2014 to 2024. Different electronic databases, including PubMed, Scopus, Web Science, ResearchGate, Google Scholar, the Cochrane Library, were searched relevant literature using Medical Subject Headings (MeSH) boolean operators. A total 317 articles obtained include PUBMED (39), Scopus (215), ResearchGate (30), Scholar (25), Library (8). From these, 186 duplicate entries eliminated, while 76 dismissed some reasons. After scanning titles, abstracts, contents remaining 55 relevance, 22 eliminated. full-text screening inclusion/exclusion criteria, an additional 11 discarded, 4 excluded during data extraction phase. In end, seven (7) publications considered based on eligibility representing 2.22%. Results showed that sequential exclusion studies did not have significant impact effects glucose control, insulin delivery, bioavailability, efficacy, safety, management. Also, had positive improvement glycemic levels, glycated hemoglobin (HbA1C) overall outcomes. The concludes harbour potential improve through enhanced However, there is gap knowledge. Further research required understand long-term safety efficacy many enlisted nanoparticles. Additionally, future should explore wider range peptides proteins encapsulation, develop delivery systems larger conformationally diverse molecules, oral bioavailability encapsulated therapeutics. Long-term clinical trials are needed validate this approach humans elucidate underlying mechanisms optimal treatment design. If these knowledge gaps addressed, will unavoidably become powerful tool effective along with traditional methods.
Язык: Английский
Процитировано
0
Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 36
Опубликована: Фев. 18, 2025
Breast cancer remains one of the significant health issues across globe, being diagnosed in millions women worldwide annually. Conventional therapeutic options have substantial adverse effects due to their non-specificity and limited drug bioavailability. Niosomes, novel delivery systems formed from non-ionic surfactants, with or without cholesterol charge-inducing agents, are used as treating BC. Their formulation by various methods enhances efficacy bioavailability minimizes side effects. Niosomal tamoxifen exhibits target enhanced stability, whereas docetaxel methotrexate show sustained controlled release, respectively.5-Fluorouracil, doxorubicin, paclitaxel, cyclophosphamide, epirubicin improved cytotoxic against BC when combined other agents. Furthermore, repurposed niosomal formulations anti-cancer drugs penetration, reduced tumor volume, significantly anti-tumor effect. This review article focuses on composition niosomes application treatment then examines how could contribute research.
Язык: Английский
Процитировано
0
Macromolecular Materials and Engineering, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Abstract This study introduces a novel approach to prepare an intestine‐targeting transport system with controlled drug release profile, combining two 3D printing techniques: selective laser sintering (SLS) and fused deposition modeling (FDM). Material evaluations indicate that mixture of Kollidon ® VA64 20% Kollicoat IR 0.2% Aeroperl has the best flow behavior exhibits optimal printability at speed 90 mm s −1 . The formulation is subsequently drug‐loaded printed cores are coated using FDM technique. core serves as carrier coating shell, consisting 95% HPMC 5% pectin, provides modified enhanced mechanical resistance tablet. acid‐resistant properties, no in pH 1.2 during first 120 min dissolution testing. In 6.8, profile shows zero‐order kinetics constant rate 0.249% (in time interval from 255 480 min). At point 720 min, 92% released. Dissolution testing thus demonstrates delayed prolonged release. Combining both methods great potential for personalized treatment intestinal inflammatory diseases.
Язык: Английский
Процитировано
0