Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 13, 2025

Resveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties. Recent studies suggest that these effects are partly mediated through the regulation of macrophage polarization, wherein macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Our review highlights how resveratrol modulates polarization various signaling pathways to achieve therapeutic effects. For example, can activate senescence-associated secretory phenotype (SASP) pathway inhibit signal transducer activator transcription (STAT3) sphingosine-1-phosphate (S1P)-YAP axes, promoting suppressing thereby inhibiting tumor growth. Conversely, it promote suppress by NF-κB activating PI3K/Akt AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. Notably, effect on is concentration-dependent; moderate concentrations tend while higher may favor polarization. This concentration dependence offers new perspectives clinical treatment but also underscores necessity precise dosage control when using resveratrol. In summary, exhibits significant potential in regulating treating related diseases.

Язык: Английский

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Gedunin Mitigates Cutibacterium acnes-Induced Skin Inflammation by Inhibiting the NF-κB Pathway

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 71 - 71

Опубликована: Янв. 9, 2025

Background/Objectives: Cutibacterium acnes (C. acnes), a bacterium residing in hair follicles, triggers acne by inducing monocyte-mediated inflammatory cytokine production. Gedunin, limonoid derived from Azadirachta indica (commonly known as neem), is renowned for its antifungal, antimalarial, anticancer, anti-inflammatory, and neuroprotective effects. However, role mitigating C. acnes-induced skin inflammation remains unexplored. This study investigates the anti-inflammatory effects of gedunin on elucidates underlying mechanisms. Methods: The activity was assessed using RAW 264.7 mouse macrophage cells bone-marrow-derived macrophages (BMDMs). Key mediators, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), were evaluated. Mechanistic studies focused nuclear factor-kappa B (NF-κB) mitogen-activated protein kinase (MAPK) signaling pathways, along with NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome. An vivo model employed to examine gedunin's therapeutic efficacy. Results: Gedunin significantly reduced expression IL-1β, TNF-α, iNOS, COX-2, IL-6 cells. It inhibited NF-κB activation without affecting MAPK JNK/SAPK, ERK, p38 MAPK. also suppressed NLRP3 inflammasome BMDMs. In model, effectively alleviated inflammation, primarily targeting signaling. Conclusions: demonstrates potential agent treatment key particularly highlights promise an alternative approach managing inflammation.

Язык: Английский

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Pharmacokinetic Profiles of Melinjo Seed Extract Components in Rats

ACS Food Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Melinjo (Gnetum gnemon L.) seeds are rich in resveratrol (RES) and its dimers, gnetin C gnemonoside A. They have various pharmacological benefits, antioxidant anti-inflammatory properties; however, their pharmacokinetics, especially animal models, must be better understood. This study aimed to elucidate the pharmacokinetics of melinjo seed extract (MSE) components rats. Plasma samples were collected up 24 h after intergastric administration MSE (1000 mg/kg), C, or A (51 μmol/kg each). RES was present as conjugates, with maximum plasma concentration (1065 nM) achieved at 6 postadministration MSE. The concentrations following sustained, absorption rates, based on AUC–dose relationship, reached 13.7 4.8%, respectively, higher than that each standard alone. These findings indicate enhances derivatives, potentially supporting therapeutic applications functional foods.

Язык: Английский

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Nano-in-microparticles approach: Targeted gastric ulcer therapy using trans-resveratrol nanoparticles encapsulated in hyaluronic acid and alginate microparticles

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141010 - 141010

Опубликована: Фев. 1, 2025

Язык: Английский

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Resveratrol and pancreatic cancers: Questions and future perspectives

World Journal of Gastrointestinal Oncology, Год журнала: 2025, Номер 17(3)

Опубликована: Фев. 13, 2025

There is still no effective treatment for pancreatic cancer, one of the deadliest malignancies among gastrointestinal diseases. Jiang et al demonstrated presence senescent cancer-associated fibroblasts (CAFs) in cancer tissues, supporting use CAFs as potential anti-cancer targets. The study indicated that a natural plant-derived compound resveratrol can reverse CAF phenotype and decrease growth, migration, invasiveness cells. Notably, might be involved regulating epithelial-to-mesenchymal transition tumor microenvironment. This editorial shares insights on future investigation signaling cells microenvironment, discusses resveratrol-based perspectives.

Язык: Английский

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Structural Insights into the Resveratrol-Piperazine Cocrystal Forms Enabling the Cocrystallization Process Development from Solution

Crystal Growth & Design, Год журнала: 2025, Номер 25(5), С. 1330 - 1343

Опубликована: Фев. 19, 2025

The aim of this study was to structurally characterize resveratrol-piperazine cocrystal forms using the single-crystal X-ray diffraction technique. Two cocrystals, designated solvent-free form (RP1) and tetrahydrofuran solvated (RP2), were successfully synthesized with a solvent-based method. crystal structure anhydrate is similar non-disordered reported in literature, but it exhibits disordered piperazine molecule. Notably, disorder leads small variations unit cell parameters compared structure, thus generating distinct as such. Nevertheless, new, identified single an intermediate that readily transforms into upon mechanical processing. stable storage at elevated temperature relative humidity, while solvate unstable under same accelerated conditions cocrystal. Additionally, solvent molecules are not bonded desolvation achieved via slurry temperatures antisolvent. This behavior makes suitable for producing more To summarize, provides comprehensive understanding cocrystallization process by revealing detailed structural characteristics forms. Furthermore, proof concept developing solution able achieve resveratrol purification simultaneously provide product enhanced aqueous solubility.

Язык: Английский

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Resveratrol in Ulcerative Colitis: Therapeutic Mechanisms, Animal Model Evidence and Novel Approaches

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 39

Опубликована: Фев. 24, 2025

Ulcerative colitis is a type of chronic inflammatory bowel disease characterised by abdominal pain, bloody diarrhoea, rectal bleeding and ulcerations in colon. This illness has significant health risks as it easily relapses, thus, providing considerable threat to human health. A number mediators, oxidative stress role gut microbes have been studied thoroughly understand the exact pathophysiology behind occurrence. Several conventional therapies are available for treatment ulcerative but each one them or other side effect. Therefore, overcome this limitation, we moving ahead towards herbal drug therapies. The current review presents emerging Resveratrol, natural occurring polyphenol derived from plant species. It associated with potential antioxidative anti-inflammatory properties. Protective effects Resveratrol different induced animal models discussed review. Various strategies improve bioavailability include encapsulation several nanocarriers. Although many proved effectiveness colitis, further research on subjects still required mechanism safety establish its uses clinically.

Язык: Английский

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A Systematic Review on the Molecular Mechanisms of Resveratrol in Protecting Against Osteoporosis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 2893 - 2893

Опубликована: Март 22, 2025

Osteoporosis is a prevalent metabolic bone disorder characterized by decreased mineral density and increased fracture risk, particularly among aging populations. While conventional pharmacological treatments exist, they often have adverse effects, necessitating the search for alternative therapies. Resveratrol, naturally occurring polyphenol, has gained significant attention its potential osteoprotective properties through various molecular mechanisms. This systematic review aims to comprehensively analyze pathways which resveratrol protects against osteoporosis. Using an advanced strategy in Scopus, PubMed, Web of Science databases, we identified 513 potentially relevant articles. After title abstract screening, followed full-text review, 28 studies met inclusion criteria. The selected comprised 14 vitro studies, 8 mixed vivo 6 1 cross-sectional study postmenopausal women. Our findings indicate that exerts effects enhancing osteoblast differentiation activation Phosphoinositide 3-Kinase/Protein Kinase B (PI3K/Akt), Sirtuin (SIRT1), AMP-Activated Protein (AMPK), GATA Binding (GATA-1) while simultaneously inhibiting osteoclastogenesis suppressing Mitogen-Activated (MAPK) TNF Receptor-Associated Factor 6/Transforming Growth Factor-β-Activated (TRAF6/TAK1). Additionally, mitigates oxidative stress inflammation-induced loss activating Hippo Signaling Pathway/Yes-Associated (Hippo/YAP) Nuclear Erythroid 2-Related 2 (NRF2) Reactive Oxygen Species/Hypoxia-Inducible Factor-1 Alpha (ROS/HIF-1α) NADPH Oxidase 4/Nuclear Kappa-Light-Chain-Enhancer Activated Cells (Nox4/NF-κB). Despite promising preclinical findings, low bioavailability remains challenge, highlighting need novel delivery strategies improve therapeutic potential. provides critical insights into mechanisms health, supporting as natural osteoporosis prevention treatment. Further clinical are required validate efficacy establish optimal dosing strategies.

Язык: Английский

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Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and treatments past decade; however, complexity heterogeneity certain breast subtypes often lead to drug resistance metastatic progression. Owing their low toxicity high variety, natural products derivatives are becoming increasingly valuable sources for small‐molecule anticancer drugs. Polyphenols more widely known role prevention as adjuvants conventional treatment strategies. Therefore, this review focuses on antitumor effects curcumin, resveratrol, polydatin cancer. According main databases, only vitro preclinical studies with solid scientific backgrounds reports protective were included. Curcumin, antioxidant, anti‐inflammatory, effects; indeed, they improve efficacy; reduce chemoresistance, angiogenesis, tumor growth; induce apoptosis, autophagy, cell cycle arrest through multiple molecular pathways, including suppression epithelial–mesenchymal transition (EMT), NF‐κB, PI3K/Akt/mTOR, c‐Jun N‐terminal kinase (JNK), MAPK, ERK1/2, STAT signaling pathways; inhibition cyclins matrix metalloproteinase (MMP)‐2 MMP‐9; activation p53 microtubule‐associated protein light chain 3 (LC3).

Язык: Английский

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Retaining Resveratrol Content in Berries and Berry Products with Agricultural and Processing Techniques: Review

Processes, Год журнала: 2024, Номер 12(6), С. 1216 - 1216

Опубликована: Июнь 13, 2024

Resveratrol is a natural compound that can be found in red wine, grapes, and berries. It has attracted attention due to its potential health benefits. The aim of this review was align ways retaining resveratrol contents berries products made berries, show which agricultural processing techniques maximize the content their how achieved. scientific literature revealed concentration berry-derived varies significantly depending on source applied. range from 0.03–0.06 mg/kg blueberries 5–10 grape skins. Agricultural such as controlled water stress (e.g., increasing grapes 8.3–11.5 mg/kg), optimal sun exposure enhancing 1.5–2.1 balanced nutrient management, selecting high-resveratrol cultivars up 15 certain grapes) substantially increase content. Processing methods like cold pressing, centrifugation, ultrafiltration, freeze-drying are effective preserving levels, while traditional pasteurization tends reduce concentration. For instance, high-temperature short-time juice 1.5 0.8 mg/kg, whereas pressing retains more (1.5 1.4 mg/kg). By optimizing these techniques, manufacturers enhance products, meeting growing consumer demand for health-enhancing supporting healthier society. This approach aligns with commitment overcoming technical challenges associated use, ensuring fully realized both health-related non-health-related applications.

Язык: Английский

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