Investigating the binding interactions of cetirizine and diphenhydramine in SDS-SDBS mixed micelles
Colloid & Polymer Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Язык: Английский
Understanding the journey of biopolymeric nanoformulations for oral drug delivery: Conventional to advanced treatment approaches
European Polymer Journal,
Год журнала:
2024,
Номер
218, С. 113338 - 113338
Опубликована: Июль 26, 2024
Язык: Английский
Transdermal Delivery of Resveratrol by a Nanomicelle-Loaded Enzyme-Triggered Hydrogel for Diabetic Wound Healing
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Язык: Английский
High throughput microparticle production using microfabricated nozzle array
RSC Advances,
Год журнала:
2025,
Номер
15(9), С. 6823 - 6832
Опубликована: Янв. 1, 2025
Microparticle
production
system
utilizing
a
microfabricated
nozzle
array
and
piezoelectric
technology
enables
precise
scalable
polymeric
microparticle
production,
offering
significant
improvements
in
drug
delivery
systems.
Язык: Английский
Cyclodextrin-Based Drug Delivery Systems for Depression: Improving Antidepressant Bioavailability and Targeted Central Nervous System Delivery
Renata Maria Văruț,
Alin Iulian Silviu Popescu,
Simina Găman
и другие.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 355 - 355
Опубликована: Март 10, 2025
Cyclodextrin
(CD)-based
drug
delivery
systems
have
emerged
as
a
promising
strategy
to
overcome
limitations
commonly
encountered
in
antidepressant
therapy,
including
low
bioavailability,
poor
solubility,
and
suboptimal
penetration
of
the
blood–brain
barrier.
This
review
synthesizes
current
evidence
demonstrating
that
complexing
various
classes
antidepressants—such
tricyclic
antidepressants
(TCAs),
selective
serotonin
reuptake
inhibitors
(SSRIs),
atypical
antidepressants—with
β-CD
or
its
derivatives
significantly
enhances
solubility
stability.
In
addition,
encapsulation
with
CDs
can
diminish
systemic
toxicity
improve
pharmacokinetics,
thereby
helping
optimize
dosage
regimens
reduce
adverse
effects.
Analysis
published
vitro
vivo
studies
indicates
CD
formulations
not
only
boost
therapeutic
efficacy
but
also
enable
sustained
targeted
release,
which
is
critical
for
drugs
requiring
precise
plasma
tissue
concentrations.
When
compared
other
carriers
(e.g.,
liposomes,
polymeric
nanoparticles,
dendrimers),
CD-based
often
stand
out
their
ease
formulation,
biocompatibility,
cost-effectiveness,
although
limited
drug-loading
capacity
be
drawback.
We
recommend
expanding
trials
substantiate
clinical
benefits
CD–antidepressant
complexes,
particularly
treatment-resistant
cases
specific
subpopulations
elderly
pediatric
patients).
Additional
investigations
should
explore
hybrid
systems—combining
advanced
nano-
macroparticles—to
amplify
advantages
address
any
limitations.
Ultimately,
integrating
into
holds
substantial
potential
refine
therapy
outcomes,
events,
pave
way
more
personalized,
effective
interventions
depression.
Язык: Английский
Construction of Chitosan Oligosaccharide-Coated Nanostructured Lipid Carriers for the Sustained Release of Strontium Ranelate
Hayeon Lim,
Yoseph Seo,
Sung Jun Min
и другие.
Tissue Engineering and Regenerative Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Язык: Английский
Advances in Nanoparticles in Targeted Drug Delivery- A Review
Results in Surfaces and Interfaces,
Год журнала:
2025,
Номер
unknown, С. 100529 - 100529
Опубликована: Апрель 1, 2025
Язык: Английский
Status Quo in the Liposome-Based Therapeutic Strategies Against Glioblastoma: “Targeting the Tumor and Tumor Microenvironment”
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11271 - 11271
Опубликована: Окт. 19, 2024
Glioblastoma
is
the
most
aggressive
and
fatal
brain
cancer,
characterized
by
a
high
growth
rate,
invasiveness,
treatment
resistance.
The
presence
of
blood-brain
barrier
(BBB)
tumor
(BBTB)
poses
challenging
task
for
chemotherapeutics,
resulting
in
low
efficacy,
bioavailability,
increased
dose-associated
side
effects.
Despite
rigorous
strategies,
including
surgical
resection,
radiotherapy,
adjuvant
chemotherapy
with
temozolomide,
overall
survival
remains
poor.
failure
current
chemotherapeutics
other
regimens
glioblastoma
necessitates
development
new
drug
delivery
methodologies
to
precisely
efficiently
target
glioblastoma.
Nanoparticle-based
systems
offer
better
therapeutic
option
glioblastoma,
considering
their
small
size,
ease
diffusion,
ability
cross
BBB.
Liposomes
are
specific
category
nanoparticles
made
up
fatty
acids.
Furthermore,
liposomes
can
be
surface-modified
particular
receptor
nontoxic.
This
review
discusses
various
methods
liposome
modification
active/directed
targeting
liposome-based
approaches
chemotherapeutic
drugs
nucleic
acids
microenvironment.
Язык: Английский
A State‐of‐the‐Art Appraisal of Nanomaterials in Microneedles in the Delivery of Therapeutics and Vaccines
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 26, 2024
Nanomaterial‐loaded
microneedles
are
a
novel
development
in
the
fields
of
medicine
and
vaccines.
Researchers
have
created
extremely
effective
systems
for
targeted
controlled
delivery
variety
bioactive
agents
by
fusing
nanomaterials
with
microneedle
platforms.
The
design
manufacturing
processes
nanomaterial‐loaded
covered
herein,
along
applications
to
improve
drug
stability,
bioavailability,
patient
adherence.
Important
preclinical
clinical
studies
that
demonstrate
efficiency
these
delivering
small
molecules,
biologics,
vaccines
also
review.
In
order
direct
ongoing
research
expedite
translation
this
promising
technology,
important
challenges
future
directions
identified.
This
review
offers
thorough
evaluation
most
recent
developments
quickly
developing
field
technology.
Язык: Английский