Dual-action of clotrimazole loaded − nanosponges vaginal gel for spermicidal action and treatment of vaginal candidiasis: Optimization, in-vitro, ex-vivo, and in-vivo experiments

International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125193 - 125193

Опубликована: Янв. 8, 2025

Язык: Английский

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Lipid Nanoparticles Carrying Essential Oils for Multiple Applications as Antimicrobials

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 178 - 178

Опубликована: Янв. 31, 2025

Lipid nanoparticles (LNPs) are versatile delivery systems with high interest because they allow the release of hydrophobic and hydrophilic molecules, such as essential oils (EOs) plant extracts. This review covers published works between 2019 2024 that have reported use EO-based LNPs antimicrobial properties applications in human animal health, well biopesticides. In healthcare field, reports addressed effect encapsulating EOs lipid nanosystems antiviral, antibacterial, antiprotozoal antifungal activities. care, this still needs to be more deeply explored while looking for sustainable alternatives against different types parasites affect health. Overall, antibacterial activities carrying described synthetic antibiotics. field agriculture, studies showed these approaches control phytopathogens other pests food production. There is a growing demand innovative technologies. However, there some challenges overcome order innovations reach market.

Язык: Английский

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Enhanced targeted liposomal delivery of imiquimod via aptamer functionalization for head and neck cancer therapy

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 243, С. 114121 - 114121

Опубликована: Июль 23, 2024

The incidence of head and neck cancers, particularly those associated with Human Papillomavirus (HPV) infections, has been steadily increasing. Conventional therapies exhibit limitations drawbacks, prompting the exploration new strategies over years, nanomedicine approaches, especially liposomes gaining relevance. Additionally, functionalization aptamers enables selective delivery to target cells. For instance, AT11 can serve as a targeting moiety for cancer cells due its high affinity nucleolin, protein overexpressed on cell's surface. In this study, functionalized are proposed drug systems imiquimod (IQ), aiming maximize potential an anticancer agent HPV-related cancers. To end, firstly were produced through ethanol injection method, AT11-TEG-Cholesteryl, characterized using dynamic light scattering. obtained presented suitable properties therapy (with sizes from 120 140 nm low polydispersity PDI < 0.16) further evaluated in terms effects. IQ-associated allowed IQ towards tongue cell line (UPCI-SCC-154) relative non-malignant (Het1A). Specifically, they induced reduction viability (∼52 % versus ∼113 %; p 0.0001), proliferation (∼68 ∼102 p<0.0001) increased death (∼7-fold increase; 0.0001)). decreased migration (from ∼24 ∼8 0.0001) invasion (to 11 = 0.0047) capacities summary, represent promising approach enhance cancer, cancer.

Язык: Английский

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AT11-guided Liposomes for Oral Cancer Cells: from characterization towards in vitro evaluation

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер unknown, С. 106214 - 106214

Опубликована: Сен. 1, 2024

Язык: Английский

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