Advances in Neurological Pain Management: Bridging Scientific Innovations and Clinical Practice

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Neuronal pain, including neuropathic migraines, and chronic pain syndromes, presents a significant global health challenge. This literature review covers studies conducted until 2024 using major databases, PubMed Google Scholar, with the search terms "Neuropathic Pain/therapy" OR "Chronic "Pain Management/methods" "Neuromodulation/methods" "Spinal Cord Stimulation" "Deep Brain "Transcranial Magnetic Direct Current "Nav1.7 Voltage-Gated Sodium Channel" "Biologics/pharmacology" "Drug Delivery Systems/methods" "Regenerative Medicine/methods" "Stem Cell Transplantation/methods" "Platelet-Rich Plasma/therapeutic use" "Tissue Engineering/methods" "Biomarkers/metabolism" "Machine Learning" "Precision Medicine." explores contemporary advancements in neurological therapy, emphasizing analytical that translate into clinical applications. The research foundation is built on modern examining mechanisms, pharmaceutical innovations, neuromodulation strategies, personalized management, regenerative medicine. Notable include neuroinflammation research, molecular genetic factor discoveries, development of selective Nav1.7 inhibitors, biologics, advanced drug delivery systems. Neuromodulation techniques, both invasive (e.g., deep brain stimulation (DBS), spinal cord (SCS)) noninvasive transcranial direct current (tDCS), magnetic (TMS)), play crucial role modulation. Regenerative approaches, stem cell platelet-rich plasma (PRP), tissue engineering, offer promising solutions for repair symptom relief. Additionally, genomic data, biomarkers, machine learning enhance precision management. Ethical considerations regarding treatment accessibility opioid alternatives remain critical, particularly Hispanic Americans facing language barriers programs like Optum. Selective serotonin reuptake inhibitors (SSRIs) continue to be widely used mental treatment. In conclusion, convergence translational innovative therapies, medicine marks transformative era improving patient outcomes quality life.

Язык: Английский

Strontium alginate hydrogel containing psoralen has superior mechanical properties and immunomodulatory functions to alleviate intervertebral disc degeneration

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142706 - 142706

Опубликована: Апрель 1, 2025

Язык: Английский

The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair

Bioactive Materials, Год журнала: 2024, Номер 45, С. 19 - 40

Опубликована: Ноя. 9, 2024

Язык: Английский