Extracellular Vesicle lncRNAs as Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers DOI Creative Commons
Panagiotis Papoutsoglou, Antonin Morillon

Non-Coding RNA, Год журнала: 2024, Номер 10(6), С. 54 - 54

Опубликована: Ноя. 5, 2024

Extracellular vesicles (EVs) are secreted by almost every cell type and considered carriers of active biomolecules, such as nucleic acids, proteins, lipids. Their content can be uptaken released into the cytoplasm recipient cells, thereby inducing gene reprogramming phenotypic changes in acceptor cells. Whether effects EVs on physiology cells mediated individual biomolecules or collective outcome total transferred EV is still under debate. The RNA consists several types RNA, messenger (mRNA), microRNA (miRNA), long non-coding (lncRNA), latter defined transcripts longer than 200 nucleotides that do not code for proteins but have important established biological functions. This review aims to update our insights functional roles their cargo during cancer progression, highlight utility novel diagnostic prognostic biomarkers cancer, tackle technological advances limitations identification, integrity assessment, preservation its functionality.

Язык: Английский

Preservation of extracellular vesicles for drug delivery: a comparative evaluation of storage buffers DOI
Tianjiao Geng, Ling Ding, Mengyang Liu

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106850 - 106850

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Targeting of Extracellular Vesicle-Based Therapeutics to the Brain DOI Creative Commons

Anastasia Williams,

Heather Branscome,

Fatah Kashanchi

и другие.

Cells, Год журнала: 2025, Номер 14(7), С. 548 - 548

Опубликована: Апрель 4, 2025

Extracellular vesicles (EVs) have been explored as promising vehicles for drug delivery. One of the most valuable features EVs is their ability to cross physiological barriers, particularly blood–brain barrier (BBB). This significantly enhances development EV-based delivery systems treatment CNS disorders. The present review focuses on factors and techniques that contribute successful therapeutics brain. Here, we discuss major methods brain targeting which includes utilization different administration routes, capitalizing biological origins EVs, modification through addition specific ligands surface EVs. Finally, current challenges in large-scale EV production loading while highlighting future perspectives regarding application

Язык: Английский

Процитировано

0
Fenretinide-Loaded Mesenchymal Stromal Cell-Derived Extracellular Vesicles as an Efficient Drug Carrier to Treat Human Neuroblastoma DOI
Alessia Zorzoli, Chiara Brignole, Claudia Cocco

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Extracellular Vesicle lncRNAs as Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers DOI Creative Commons
Panagiotis Papoutsoglou, Antonin Morillon

Non-Coding RNA, Год журнала: 2024, Номер 10(6), С. 54 - 54

Опубликована: Ноя. 5, 2024

Extracellular vesicles (EVs) are secreted by almost every cell type and considered carriers of active biomolecules, such as nucleic acids, proteins, lipids. Their content can be uptaken released into the cytoplasm recipient cells, thereby inducing gene reprogramming phenotypic changes in acceptor cells. Whether effects EVs on physiology cells mediated individual biomolecules or collective outcome total transferred EV is still under debate. The RNA consists several types RNA, messenger (mRNA), microRNA (miRNA), long non-coding (lncRNA), latter defined transcripts longer than 200 nucleotides that do not code for proteins but have important established biological functions. This review aims to update our insights functional roles their cargo during cancer progression, highlight utility novel diagnostic prognostic biomarkers cancer, tackle technological advances limitations identification, integrity assessment, preservation its functionality.

Язык: Английский

Процитировано

0