Materials chemistry horizons., Год журнала: 2024, Номер 3(3), С. 1 - 14
Опубликована: Дек. 1, 2024
Язык: Английский
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Язык: Английский
Процитировано
0
Journal of Animal Physiology and Animal Nutrition, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Nanotechnology has revolutionized nutritional strategies in poultry production, offering innovative solutions to enhance health and performance. Minerals such as chromium (Cr), zinc (Zn), calcium (Ca), copper (Cu), selenium (Se), iron (Fe) have been extensively studied for their effects on growth, health, feed efficiency. Among these, mineral nanoparticles (MNPs) emerged promising tools optimizing nutrient bioavailability nutrigenomic effects. synergizes with nutrigenomics by delivering nutrients bioactive compounds nano-form enhanced absorption bioavailability. This review explores the potential of MNPs poultry, focusing how these nanoscale particles can modulate gene expression, metabolic pathways, cellular functions optimize outcomes. The properties fasciliate targeted modulation expression related immune function, stress response, efficiency, leading improved performance birds. Additionally, shown significant absorption, antioxidant defense, gut thermal tolerance, which are crucial productive poultry. Integrating nanotechnology nutrigenomics, offer a sustainable approach addressing key challenges nutrition, deficiencies, heat stress, disease susceptibility. highlights interact genome, influencing epigenetic mechanisms improving overall productivity. current study importance exploring intersection nanotechnology, genomics devise
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 30, С. 101445 - 101445
Опубликована: Янв. 5, 2025
Chemotherapy is widely recognized as a highly efficacious modality for cancer treatment, involving the administration of chemotherapeutic agents to target and eradicate tumor cells. Currently, oral stands prevailing utilized method delivering chemotherapy drugs. However, majority anti-tumor medications exhibit limited solubility permeability, poor stability in harsh gastrointestinal environments, thereby impeding their therapeutic efficacy chemotherapy. Therefore, more micro-nano drug delivery carriers have been developed used effectively deliver anti-cancer drugs, which can overcome physiological barriers, facilitate administration, ultimately improve efficacy. In this paper, we first discuss effects various biological barriers on approach. Then, development based biomedical components, such micelles, dendrimers, hydrogels, liposomes, inorganic nanoparticles, etc. were introduced. Finally, current dilemma potential clinical treatment discussed. The primary objective review introduce methods serve point reference advancement novel carriers, with ultimate goal informing future applications.
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2025, Номер 17(2), С. 198 - 198
Опубликована: Янв. 9, 2025
Mathematical models are crucial for predicting the behavior of drug conjugate nanoparticles and optimizing delivery systems in cancer therapy. These simulate interactions among nanoparticle properties, tumor characteristics, physiological conditions, including resistance targeting specificity. However, they often rely on assumptions that may not accurately reflect vivo conditions. In vitro studies, while useful, fully capture complexities environment, leading to an overestimation nanoparticle-based therapy effectiveness. Advancements mathematical modeling, supported by preclinical data artificial intelligence, vital refining therapies improving their translation into effective clinical treatments.
Язык: Английский
Процитировано
0
Indus journal of bioscience research., Год журнала: 2025, Номер 3(1), С. 429 - 437
Опубликована: Янв. 20, 2025
Plant virus nanoparticles (VNPs) are inexpensive to produce, dependable, and reusable have emerged as a versatile promising platform in nanomedicine, particularly cancer therapy. These biogenic nanostructures possess unique physicochemical properties, including biocompatibility, biodegradability, structural uniformity, making them ideal candidates for targeted drug delivery. The ability of such encapsulate chemotherapeutic agents functionalize with tumor-specific ligands facilitates precise delivery cancerous tissues, minimizing off-target effects enhancing therapeutic efficacy. In addition, plant viral vectors (VLPs) an attractive option causing anti-tumor immunity because they undoubtedly secure, harmless, suitable mass manufacture pharmacological adaptation. This review delves into the molecular architecture nanoparticles, their functional modifications, mechanisms by which interact cells. Additionally, it highlights preclinical studies emerging clinical applications, addressing both opportunities challenges translating VNPs from bench bedside. By exploring anticancer potentials VNPs, this paper aims underscore role shaping future sustainable, plant-derived nanotechnology oncology.
Язык: Английский
Процитировано
0
RSC Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Paclitaxel and carboplatin-loaded polybasic nanogels are internalized by cancer cells via endocytosis, undergo cationic swelling endosomal escape, ultimately induce apoptosis.
Язык: Английский
Процитировано
0
Frontiers in Nanotechnology, Год журнала: 2025, Номер 7
Опубликована: Апрель 14, 2025
Multimetallic nanoparticles (MMNPs) produced by fungus-mediated synthesis have attracted a lot of interest as an environmentally friendly and sustainable nanotechnology method. Fungi are effective bio-factories that create complex with special qualities using their metabolic enzymatic capabilities. When compared to monometallic counterparts, MMNPs—which composed combinations two or more metals—offer synergistic benefits such increased catalytic activity, higher stability, superior biocompatibility. In addition highlighting the structural diversity MMNPs, core-shell, alloy, Janus configurations, this review investigates mechanisms underpinning fungal-mediated synthesis, including reduction stabilisation pathways. Additionally covered characterisation methods for examining functionality, morphology, composition. The potential applications MMNPs synthesized fungi in biomedicine, environmental remediation, biosensing, catalysis highlighted article. This green method, which makes use natural fungus multimetallic systems, responds increasing need nanomaterials opens door novel uses both scientific industrial fields.
Язык: Английский
Процитировано
0
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2025, Номер 17(2)
Опубликована: Март 1, 2025
ABSTRACT Nucleic acid (NA) therapy holds tremendous potential for treating a wide range of genetic diseases by the delivery therapeutic genes into target cells. However, significant challenges exist in safely and effectively delivering these to their intended locations. Viral vectors, though efficient, pose risks such as immunogenicity mutagenesis. This has resulted growing interest non‐viral, nanoparticle‐based NA systems. review article describes various physiological barriers explores systems, including bioengineered nanoparticles, peptides, lipid polymeric highlighting unique features overcome vivo delivery. While systems offer promising alternative viral related cytotoxicity, reproducible synthesis, cost need be addressed. The current clinical landscape is also discussed, emphasizing safer, scalable, cost‐effective solutions. Nanoparticles represent future therapy, with possibility developing clinically relevant, non‐toxic, stable, non‐immunogenic vehicles, paving way broader applications improved outcomes.
Язык: Английский
Процитировано
0
Bioprinting, Год журнала: 2024, Номер unknown, С. e00373 - e00373
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
3
Jundishapur Journal of Natural Pharmaceutical Products, Год журнала: 2024, Номер 19(4)
Опубликована: Ноя. 10, 2024
Background: Limitations in drug penetration are overcome by nanotechnology, particularly liposomes, which enhance targeted administration of ocular medications. Liposomes can augment the therapeutic effects curcumin, a natural compound with positive impacts on retina. Treatments for eye diseases also benefit from antibacterial properties ozonated oil liposomes. Objectives: This study aims to develop and evaluate liposomes loaded curcumin delivery applications, specifically targeting diabetic retinopathy (DR). Methods: Liposomal nanoparticles were prepared using thin-film hydration, incorporating phospholipids, lecithin, cholesterol, oil, curcumin. We assessed physicochemical including particle size, zeta potential, encapsulation efficiency (EE), morphology. Drug release profiles stability studies conducted. Results: The optimized showed size 84.77 nm, potential -16.8 mV, an EE 94.73%. formulation exhibited sustained over 24 hours, reaching 82.09% cumulative release. Stability indicated minimal changes key parameters three months at room temperature. Conclusions: developed liposomal demonstrates promising characteristics delivery, potentially enhancing its efficacy DR.
Язык: Английский
Процитировано
0