Cancers, Год журнала: 2025, Номер 17(4), С. 685 - 685

Опубликована: Фев. 18, 2025

New therapeutic approaches that antagonize tumour-promoting phenotypes in lung cancer are needed to improve patient outcomes. Chromosomal instability (CIN) is a hallmark of characterized by the ongoing acquisition genetic alterations include gain and loss whole chromosomes or segments as well chromosomal rearrangements during cell division. Although it provides diversity fuels tumour evolution enables aggressive like immune evasion, metastasis, drug resistance, too much CIN can be lethal because creates imbalances disrupt essential genes induce severe proteotoxic metabolic stress. As such, sustaining advantageous levels compatible with survival fine balance cells, potentiating exceed tolerable threshold promising treatment strategy for inherently unstable tumours cancer. Kinesins superfamily motor proteins many members having functions mitosis critical correct segregation and, consequently, maintaining genomic integrity. Accordingly, inhibition such kinesins has been shown exacerbate CIN. Therefore, inhibiting mitotic represents amplifying vulnerable cells. In this review, we describe concept vulnerability comprehensively summarize studies reporting clinical functional relevance cancer, goal outlining how kinesin inhibition, "targeting kinesins", holds great potential an effective treating

Язык: Английский