Journal of Molecular Modeling, Год журнала: 2024, Номер 30(12)
Опубликована: Ноя. 15, 2024
Язык: Английский
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 6, 2025
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, necessitating innovative therapeutic approaches. Polymer-based nanotechnology has emerged as a promising solution, offering precise drug delivery, enhanced blood-brain barrier (BBB) penetration, adaptability to tumor microenvironment (TME). This review explores diverse applications polymeric nanoparticles (NPs) in GBM treatment, including delivery chemotherapeutics, targeted therapeutics, immunotherapeutics, other agents for radiosensitization photodynamic therapy. Recent advances multifunctional polymer highlight their potential overcome challenges that brought, such heterogeneity tumor, BBB limitation, immunosuppressive TME, consideration biocompatibility safety. Meanwhile, future directions address these are also proposed. By addressing obstacles, polymer-based represents transformative strategy improving treatment outcomes, paving way more effective patient-specific therapies.
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 10, 2025
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of cancer, characterized by frequent recurrence, metastasis, and poor survival outcomes despite chemotherapy-based treatments. This study aims to investigate the mechanisms which Traditional Chinese Medicine (TCM) modulates tumor immune microenvironment in TNBC, utilizing CiteSpace bioinformatics analysis. We employed analyze treatment hotspots key TCM formulations, followed analysis identify main active components, targets, associated pathways, their clinical implications TNBC treatment. highlighted including Sanhuang Decoction. Network pharmacology identified major bioactive components such as Mutatochrome, Physcion diglucoside, Procyanidin B-5,3'-O-gallate, gallic acid-3-O-(6'-O-galloyl)-glucoside, isomucronulatol-7,2'-di-O-glucosiole, with core targets Mitogen-Activated Protein Kinase 1 (MAPK1), Janus 2 (JAK2), Lymphocyte-specific protein tyrosine kinase (LCK). These were found be involved regulation, particularly modulation CD8+ CD4+ T cells. Additionally, improved recurrence-free (RFS) overall (OS) patients. The therapeutic effects primarily involve within microenvironment, through regulation
Язык: Английский
Процитировано
0
Food and Chemical Toxicology, Год журнала: 2025, Номер 197, С. 115303 - 115303
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2025, Номер unknown, С. e42753 - e42753
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(4), С. 260 - 260
Опубликована: Апрель 1, 2025
Stroke remains a leading cause of disability worldwide, underscoring the urgent need for novel and innovative therapeutic strategies to enhance neuroprotection, support regeneration, improve functional recovery. Previous research has shown that phytochemicals such as curcumin, tannic acid, gallic ginsenosides, resveratrol, isorhamnetin display extensive neuroprotective properties, including antioxidant, anti-inflammatory, anti-apoptotic effects. These natural compounds could also promote neurogenesis, angiogenesis, preservation blood–brain barrier. Despite their promising bioactivities, clinical application is often limited by poor solubility, bioavailability, suboptimal pharmacokinetics. Hydrogels offer solution encapsulating controlling gradual release these directly at site injury. Recent advancements in hydrogel formulations, constructed from biopolymers functionalized using nanotechnological approaches, significantly stability, targeted delivery phytochemicals. Controlled profiles pH-sensitive environment-responsive hydrogels ensure compounds’ effects are optimally timed with individual critical stages post-stroke repair. Moreover, scaffolds tailored material properties biocompatibility can create favorable microenvironment, reducing secondary inflammation, enhancing tissue potentially improving cognitive outcomes following stroke. This review explores potential integrating within hydrogel-based systems specifically designed The design synthesis biocompatible, biodegradable especially applications discussed. Lastly, we emphasize additional robust translatable preclinical studies.
Язык: Английский
Процитировано
0
Journal of Molecular Modeling, Год журнала: 2024, Номер 30(12)
Опубликована: Ноя. 15, 2024
Язык: Английский
Процитировано
1