Adherence to Inhalation Therapy Among COPD Patients: A Cross-Sectional Study in a Tertiary Hospital in Quito, Ecuador
International Journal of COPD,
Год журнала:
2025,
Номер
Volume 20, С. 399 - 410
Опубликована: Фев. 1, 2025
Chronic
Obstructive
Pulmonary
Disease
(COPD),
the
third
leading
cause
of
death
globally,
poses
a
significant
public
health
burden.
Despite
its
high
prevalence,
underdiagnosis
and
poor
treatment
adherence
remain
major
challenges,
contributing
to
increased
hospitalization
mortality.
This
study
aimed
assess
inhalation
therapy
among
COPD
patients
treated
at
specialty
hospital
in
Quito,
Ecuador.
A
cross-sectional
was
conducted
on
85
diagnosed
with
tertiary
Quito.
Data
collected
through
face-to-face
surveys,
utilizing
TAI-10
questionnaire
adherence,
along
demographic
clinical
characteristics
patients.
Among
participants,
34.1%
demonstrated
good
therapy,
while
32.9%
exhibited
intermediate
were
non-adherent.
The
majority
older
adults
aged
≥76
years
(67.1%)
prevalence
comorbidities
(91.8%),
particularly
hypertension
(58.8%).
Non-adherence
primarily
associated
forgetfulness
financial
constraints.
Higher
BMI
significantly
linked
better
obese
showing
higher
odds
(OR=7.228,
95%
CI
1.866-27.996)
(OR=9.966,
2.538-39.139).
Approximately
one-third
Ecuador
demonstrate
similar
proportions
show
or
adherence.
Predominantly
retirees
comorbidities,
population
identified
constraints
as
key
barriers.
These
findings
emphasize
need
for
enhanced
patient
education,
regular
follow-ups,
tailored
support
vulnerable
groups.
Язык: Английский
Effects of Surface Charge of Inhaled Liposomes on Drug Efficacy and Biocompatibility
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 329 - 329
Опубликована: Март 3, 2025
Objectives:
Liposomes
are
a
promising
drug
carrier
for
inhaled
delivery
systems
and
their
physical
parameters
could
influence
therapeutic
efficacy
significantly.
This
study
was
designed
to
answer
the
specific
question
of
proper
surface
charge
liposomes
in
pulmonary
inhalation,
as
well
synergistic
anti-inflammation
between
drugs.
Methods:
In
this
work,
series
drug-loaded
with
different
charges
(from
negative
positive)
were
prepared,
several
vitro
vivo
assays,
including
cytotoxicity,
hemolysis
assay,
mucus
penetration
lipopolysaccharide
(LPS)-induced
pneumonia
model
test,
adopted
evaluate
biocompatibility
above
liposomes.
Results:
Compared
cationic
liposomes,
anionic
capable
better
good
(low
blood
compatibility
mild
tissue
inflammation),
but
poor
cellular
uptake
by
immune
cells.
specific,
even
when
liposome
only
+2.6
mV,
its
cytotoxicity
reached
around
20%
15%,
respectively.
Furthermore,
there
no
significant
difference
(−25.9
vs.
−2.5
mV),
slightly
negative-charged
exhibited
uptake.
Conclusions:
Thus,
(−1~−3
mV)
be
considering
both
biocompatibility.
an
LPS-induced
mouse
model,
achieved
anti-inflammatory
compared
free
Язык: Английский