Radiolytic Elimination of Nabumetone from Aqueous Solution: Degradation Efficiency, and Degradants’ Toxicity DOI Creative Commons
Ivana Tartaro Bujak, David Klarić, Bono Lučić

и другие.

Molecules, Год журнала: 2024, Номер 30(1), С. 64 - 64

Опубликована: Дек. 27, 2024

Advanced oxidation processes (AOPs), including ionizing radiation treatment, are increasingly recognized as an effective method for the degradation of pharmaceutical pollutants, non-steroidal anti-inflammatory drugs (NSAIDs). Nabumetone (NAB), a widely used NSAID prodrug, poses environmental risk due to its persistence in aquatic ecosystems and potential toxicity non-target organisms. In this study, radiolytic NAB was investigated under different experimental conditions (dose rate, radical scavenging, pH, matrix effect), products evaluated. rapidly degraded at 300 Gy with prolonged irradiation. Mineralization about 88% solutions observed based on evaluation total organic carbon (TOC). The most efficient occurred N2O conditions, while it retarded presence thiourea. water components had significant influence efficiency degradation. addition, main were identified by LC-HRMS. Toxicity studies bacteria showed no impact products, silico predictive methods revealed their slightly increased compared parent compound, but considerably lower comparison active form 6-methoxy-2-naphthylacetic acid (MNA). Additionally, significantly toxicities predicted saturated solution. These results underline importance optimizing irradiation parameters minimizing formation harmful by-products. Understanding all aspects AOP toxicological effects ensures mitigation health risks treatment processes.

Язык: Английский

Radiolytic Elimination of Nabumetone from Aqueous Solution: Degradation Efficiency, and Degradants’ Toxicity DOI Creative Commons
Ivana Tartaro Bujak, David Klarić, Bono Lučić

и другие.

Molecules, Год журнала: 2024, Номер 30(1), С. 64 - 64

Опубликована: Дек. 27, 2024

Advanced oxidation processes (AOPs), including ionizing radiation treatment, are increasingly recognized as an effective method for the degradation of pharmaceutical pollutants, non-steroidal anti-inflammatory drugs (NSAIDs). Nabumetone (NAB), a widely used NSAID prodrug, poses environmental risk due to its persistence in aquatic ecosystems and potential toxicity non-target organisms. In this study, radiolytic NAB was investigated under different experimental conditions (dose rate, radical scavenging, pH, matrix effect), products evaluated. rapidly degraded at 300 Gy with prolonged irradiation. Mineralization about 88% solutions observed based on evaluation total organic carbon (TOC). The most efficient occurred N2O conditions, while it retarded presence thiourea. water components had significant influence efficiency degradation. addition, main were identified by LC-HRMS. Toxicity studies bacteria showed no impact products, silico predictive methods revealed their slightly increased compared parent compound, but considerably lower comparison active form 6-methoxy-2-naphthylacetic acid (MNA). Additionally, significantly toxicities predicted saturated solution. These results underline importance optimizing irradiation parameters minimizing formation harmful by-products. Understanding all aspects AOP toxicological effects ensures mitigation health risks treatment processes.

Язык: Английский

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