Preparation and Stability Evaluation of Flexible Nanoliposomes Co-Encapsulated with Black Wolfberry Anthocyanins and EGCG

LWT, Год журнала: 2025, Номер unknown, С. 117402 - 117402

Опубликована: Янв. 1, 2025

Язык: Английский

Cyclodextrin-Based Drug Delivery Systems for Depression: Improving Antidepressant Bioavailability and Targeted Central Nervous System Delivery

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 355 - 355

Опубликована: Март 10, 2025

Cyclodextrin (CD)-based drug delivery systems have emerged as a promising strategy to overcome limitations commonly encountered in antidepressant therapy, including low bioavailability, poor solubility, and suboptimal penetration of the blood–brain barrier. This review synthesizes current evidence demonstrating that complexing various classes antidepressants—such tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), atypical antidepressants—with β-CD or its derivatives significantly enhances solubility stability. In addition, encapsulation with CDs can diminish systemic toxicity improve pharmacokinetics, thereby helping optimize dosage regimens reduce adverse effects. Analysis published vitro vivo studies indicates CD formulations not only boost therapeutic efficacy but also enable sustained targeted release, which is critical for drugs requiring precise plasma tissue concentrations. When compared other carriers (e.g., liposomes, polymeric nanoparticles, dendrimers), CD-based often stand out their ease formulation, biocompatibility, cost-effectiveness, although limited drug-loading capacity be drawback. We recommend expanding trials substantiate clinical benefits CD–antidepressant complexes, particularly treatment-resistant cases specific subpopulations elderly pediatric patients). Additional investigations should explore hybrid systems—combining advanced nano- macroparticles—to amplify advantages address any limitations. Ultimately, integrating into holds substantial potential refine therapy outcomes, events, pave way more personalized, effective interventions depression.

Язык: Английский

Insights into Liposomal and Gel-Based Formulations for Dermatological Treatments

Gels, Год журнала: 2025, Номер 11(4), С. 245 - 245

Опубликована: Март 26, 2025

Dermatological diseases pose a significant challenge due to their chronic nature, complex pathophysiology, and the need for effective, patient-friendly treatments. Recent advancements in liposomal gel-based formulations have played crucial role improving drug delivery, therapeutic efficacy, patient compliance. Liposomal garnered considerable attention dermatology ability encapsulate both hydrophilic lipophilic compounds, enabling controlled release enhanced skin penetration. However, challenges such as formulation complexity, stability issues, regulatory constraints remain. Similarly, are widely used ease of application, biocompatibility, retain active ingredients. they also face limitations, including restricted penetration depth, susceptibility microbial contamination, achieving sustained release. The integration technologies offers promising strategy overcome current optimize dermatological delivery. This review explores well-established therapies recent innovations, offering comprehensive overview applications treatment prevalent conditions. Ultimately, continued research is essential refine these formulations, expanding clinical utility enhancing effectiveness dermatology.

Язык: Английский