Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment DOI Creative Commons
Si-Jie Zhang, Ran Xu, Shao‐Bin He

и другие.

Military Medical Research, Год журнала: 2025, Номер 12(1)

Опубликована: Май 31, 2025

Abstract The treatment of chronic wounds presents significant challenges due to the necessity accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances. Factors such as bacterial infections, hyperglycemia, oxidative stress disrupt cellular functions impair angiogenesis, substantially delaying wound repair. Nanozymes, which are engineered nanoscale materials with enzyme-like activities, offer distinct advantages over conventional enzymes traditional nanomaterials, making them promising candidates for treatment. To enhance their clinical potential, nanozyme-based catalytic systems currently being optimized through formulation advancements preclinical studies assessing biocompatibility, anti-oxidant activity, antibacterial efficacy, tissue repair capabilities, ensuring safety applicability. When integrated into multifunctional dressings, nanozymes modulate reactive oxygen species levels, promote regeneration, simultaneously combat infections damage, extending beyond catalysis in customizable architectures enable precise therapeutic applications, enhancing effectiveness managing conditions. This review provides a comprehensive analysis incorporation detailing fabrication methods emphasizing transformative potential management. By identifying addressing key limitations, we introduce strategic drive development nanozyme-driven paving way next-generation treatments.

Язык: Английский

Nanozyme-driven multifunctional dressings: moving beyond enzyme-like catalysis in chronic wound treatment DOI Creative Commons
Si-Jie Zhang, Ran Xu, Shao‐Bin He

и другие.

Military Medical Research, Год журнала: 2025, Номер 12(1)

Опубликована: Май 31, 2025

Abstract The treatment of chronic wounds presents significant challenges due to the necessity accelerating healing within complex microenvironments characterized by persistent inflammation and biochemical imbalances. Factors such as bacterial infections, hyperglycemia, oxidative stress disrupt cellular functions impair angiogenesis, substantially delaying wound repair. Nanozymes, which are engineered nanoscale materials with enzyme-like activities, offer distinct advantages over conventional enzymes traditional nanomaterials, making them promising candidates for treatment. To enhance their clinical potential, nanozyme-based catalytic systems currently being optimized through formulation advancements preclinical studies assessing biocompatibility, anti-oxidant activity, antibacterial efficacy, tissue repair capabilities, ensuring safety applicability. When integrated into multifunctional dressings, nanozymes modulate reactive oxygen species levels, promote regeneration, simultaneously combat infections damage, extending beyond catalysis in customizable architectures enable precise therapeutic applications, enhancing effectiveness managing conditions. This review provides a comprehensive analysis incorporation detailing fabrication methods emphasizing transformative potential management. By identifying addressing key limitations, we introduce strategic drive development nanozyme-driven paving way next-generation treatments.

Язык: Английский

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