Kollicoat® Smartseal 100P for Developing Theophylline Pellets: Exploring Taste-Masking Potential for Pediatric Applications DOI Creative Commons
Neeraja Komanduri, Mashan Almutairi, Rasha M. Elkanayati

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 413 - 413

Опубликована: Март 25, 2025

Background/Objectives: This study aimed to develop and evaluate taste-masked theophylline pellets using hot-melt extrusion (HME) technology. Additionally, the evaluates efficacy of various taste-masking polymers by comparing three pH-dependent polymers, Kollicoat® Smartseal 100P, Eudragit® EPO, MAE 100-55, in masking taste optimizing drug release. Methods: Formulations were designed with varying loads (10%, 20%, 30%) plasticizer concentrations (20% 30% PEG 1500). Lead formulations characterized differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), bitter threshold level, vitro release testing. Stability was assessed under accelerated conditions (40 °C ± 2 75% 5% RH) for months. Results: DSC confirmed homogenous dispersion within polymer matrix. The optimized formulation comprising 20% theophylline, 1500, 60% 100P demonstrated effective masking, releasing only 1.1% simulated salivary fluid (SSF) two minutes, significantly lower than pure (29.5%, p < 0.05), 100-55 (2.8%, comparable EPO (2.1%, > 0.05). Solubility studies further that from lead remained well below its reported threshold, which could prevent perception mitigate bitterness. In gastric fluid, complete achieved while exhibited limited showed maintained texture, efficacy, dissolution profile conditions. Conclusions: demonstrates novel exploration HME application, effectiveness achieving robust improving patient compliance, particularly pediatric geriatric populations.

Язык: Английский

Kollicoat® Smartseal 100P for Developing Theophylline Pellets: Exploring Taste-Masking Potential for Pediatric Applications DOI Creative Commons
Neeraja Komanduri, Mashan Almutairi, Rasha M. Elkanayati

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 413 - 413

Опубликована: Март 25, 2025

Background/Objectives: This study aimed to develop and evaluate taste-masked theophylline pellets using hot-melt extrusion (HME) technology. Additionally, the evaluates efficacy of various taste-masking polymers by comparing three pH-dependent polymers, Kollicoat® Smartseal 100P, Eudragit® EPO, MAE 100-55, in masking taste optimizing drug release. Methods: Formulations were designed with varying loads (10%, 20%, 30%) plasticizer concentrations (20% 30% PEG 1500). Lead formulations characterized differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), bitter threshold level, vitro release testing. Stability was assessed under accelerated conditions (40 °C ± 2 75% 5% RH) for months. Results: DSC confirmed homogenous dispersion within polymer matrix. The optimized formulation comprising 20% theophylline, 1500, 60% 100P demonstrated effective masking, releasing only 1.1% simulated salivary fluid (SSF) two minutes, significantly lower than pure (29.5%, p < 0.05), 100-55 (2.8%, comparable EPO (2.1%, > 0.05). Solubility studies further that from lead remained well below its reported threshold, which could prevent perception mitigate bitterness. In gastric fluid, complete achieved while exhibited limited showed maintained texture, efficacy, dissolution profile conditions. Conclusions: demonstrates novel exploration HME application, effectiveness achieving robust improving patient compliance, particularly pediatric geriatric populations.

Язык: Английский

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