Applied Food Research, Год журнала: 2025, Номер unknown, С. 100906 - 100906
Опубликована: Апрель 1, 2025
Язык: Английский
Indus journal of bioscience research., Год журнала: 2025, Номер 3(1), С. 325 - 336
Опубликована: Янв. 16, 2025
Nanoparticles have become a transforming platform in drug delivery systems. Their remarkable advancement over traditional methods builds upon an improvement bioavailability, stability, and controlled of therapeutic agents. Here, we discuss the broad spectrum potential nanoparticle-based Challenges, innovations, surface modification strategies that affect their clinical translation are discussed. Notwithstanding they present, challenges including biocompatibility, toxicity, targeting efficiency persist restricting extensive utilization. The review emphasizes recent advancements, stimuli-responsive nanoparticles, which provide release reaction to environmental triggers, as well targeted delivery, facilitates selective accumulation agents at designated sites disease. Besides, techniques, such PEGylation, ligand conjugation, charge modulation, been highly promising improving stability reducing immunogenicity, enhancing cellular uptake. future systems based on nanoparticles will address these through new innovations nanoparticle design effect more effective treatments. While research advances, likely bring revolution personalized medicine, tailoring medical therapy for different diseases with minimal side effects better patient outcomes.
Язык: Английский
Процитировано
0
Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 43
Опубликована: Фев. 19, 2025
In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms breast like triple-negative (TNBC). This review delves into significant role liposomes in enhancing effectiveness by leveraging cancer-specific mechanisms such as induction immunogenic cell death (ICD), reprogramming tumor microenvironment (TME), and enabling sequential drug release. We examine innovative dual-targeting that capitalize on heterogeneity, well pH-sensitive formulations offer improved control over delivery. Unlike prior analyses, this directly links advancements preclinical research-such PAMAM dendrimer-based nanoplatforms RGD-decorated liposomes-to clinical trial results, highlighting their potential to revolutionize TNBC treatment strategies. Additionally, we address ongoing challenges related scalability, toxicity, regulatory compliance, propose future directions personalized, immune-focused nanomedicine. work not only synthesizes latest research but also offers a framework translating liposomal from laboratory practice.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106739 - 106739
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Results in Surfaces and Interfaces, Год журнала: 2025, Номер unknown, С. 100473 - 100473
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Expert Opinion on Drug Delivery, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
Apigenin, a widely distributed bioactive flavonoid, has recently gained excellent attention among researchers as an effective anticancer drug that can alternate cancer signaling pathways, induce programmed cell death, and reduce tumor growth in various types. Despite its impressive anti-neoplastic activity, high hydrophobicity nonspecific biodistribution make apigenin difficult for pharmaceutical application. We highlighted the therapeutic potential of derivatives different types, along with their mechanism action. Nanoengineered delivery systems have remarkable applications minimizing degradation enhancing efficacy drugs sustained release, prolonged blood retention time, reduced off-target toxicities. This review evaluated explored molecular interactions this novel flavonoid pathways to selectively inhibit neoplastic development multiple To ensure complete coverage research area, google scholar, PubMed, web science were used find not only most relevant, but also connected similar articles. A comprehensive overview nanotherapy treatment establish platform overcome difficulties application efficient clinical translation from bench bedside.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2689 - 2689
Опубликована: Март 17, 2025
Drug delivery systems enhance drug efficacy while minimizing side effects. Liposomes, as well-studied and clinically approved carriers, offer biodegradability, biocompatibility, low toxicity, making them suitable for delivering various pharmacological agents. Granulocyte colony-stimulating factor (G-CSF), a key growth factor, has shown therapeutic potential, particularly in infertility treatment. It effectively manages chronic refractory endometritis by improving endometrial receptivity increasing embryo implantation success. Studies indicate that G-CSF promotes enhances the uterine microenvironment, benefiting patients with recurrent failures endometritis. Encapsulation of liposomes its stability, bioavailability, controlled release. G-CSF-loaded were prepared using passive loading via thin-film hydration method. The size liposomes, polydispersity index (PDI), zeta potential determined dynamic electrophoretic light scattering methods, encapsulation efficiency was measured high-performance liquid chromatography. morphology established confirmed cryogenic transmission electron microscopy. cytocompatibility evaluated on human dermal fibroblasts an MTT assay. had average particle 161.9 ± 9.9 nm, PDI 0.261 0.03, +2.09 0.10 mV, exhibiting high physical stability during long-term storage at +4 °C 60% humidity. method resulted 52.37 3.64% active substance. analysis cell viability revealed no cytotoxicity toward loaded demonstrated dose-dependent effect fibroblasts. Thus, obtained data confirm successful preparation liposomes. However, to fully understand their effectiveness biomedical applications, further research is needed, including evaluation vivo. Such studies will help determining these formulations specific purposes evaluating safety living systems.
Язык: Английский
Процитировано
0
Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 20
Опубликована: Март 24, 2025
Liposomes represent a highly promising drug delivery platform for wide range of pharmaceutical compounds. The encapsulation efficiency (EE) stands as critical quality attribute liposomal formulations. Accurate determination EE requires quantification at least two parameters among the three distinct populations: total content, encapsulated fraction, and free concentration. However, due to complex physicochemical characteristics liposomes, particularly their structural flexibility, surface charge properties, organic phase composition, direct measurement fractions presents significant analytical challenges. ability precisely quantify both concentrations in formulations enables rapid reliable evaluation efficiency, which is essential guiding formulation optimization ensuring consistent product during scale-up manufacturing processes. This review provides comprehensive analysis various techniques determination, including (reverse) dialysis, ultrafiltration centrifugation, differential centrifugation (ultra/low-speed), size exclusion chromatography, with particular emphasis on methodological characteristics, applicable ranges, advantages, limitations. Furthermore, we propose appropriate detection strategies assessment based specific laboratory capabilities properties investigational
Язык: Английский
Процитировано
0
Gels, Год журнала: 2025, Номер 11(4), С. 245 - 245
Опубликована: Март 26, 2025
Dermatological diseases pose a significant challenge due to their chronic nature, complex pathophysiology, and the need for effective, patient-friendly treatments. Recent advancements in liposomal gel-based formulations have played crucial role improving drug delivery, therapeutic efficacy, patient compliance. Liposomal garnered considerable attention dermatology ability encapsulate both hydrophilic lipophilic compounds, enabling controlled release enhanced skin penetration. However, challenges such as formulation complexity, stability issues, regulatory constraints remain. Similarly, are widely used ease of application, biocompatibility, retain active ingredients. they also face limitations, including restricted penetration depth, susceptibility microbial contamination, achieving sustained release. The integration technologies offers promising strategy overcome current optimize dermatological delivery. This review explores well-established therapies recent innovations, offering comprehensive overview applications treatment prevalent conditions. Ultimately, continued research is essential refine these formulations, expanding clinical utility enhancing effectiveness dermatology.
Язык: Английский
Процитировано
0
Applied Food Research, Год журнала: 2025, Номер unknown, С. 100906 - 100906
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0