Smart Drug Delivery Systems Based on Cyclodextrins and Chitosan for Cancer Therapy DOI Creative Commons

Larisa Păduraru,

Alina Diana Panainte, Cătălina A. Peptu

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 564 - 564

Опубликована: Апрель 13, 2025

Despite improvements in therapeutic approaches like immunotherapy and gene therapy, cancer still remains a serious threat to world health due its high incidence mortality rates. Limitations of conventional therapy include suboptimal targeting, multidrug resistance, systemic toxicity. A major challenge current oncology therapies is the development new delivery methods for antineoplastic drugs that act directly on target. One approach involves complexation antitumor with cyclodextrins (CDs) chitosan (CS) as an attempt counteract their primary limitations: low water solubility bioavailability, diminished vitro vivo stability, dose-dependent All those drawbacks may potentially exclude some candidates from clinical trials, thus integration into smart systems or drug-targeting technologies must be implemented. We intended overview drug based regard diagnosis management. This narrative review encompasses full-length articles published English between 2019 2025 (including online ahead print versions) PubMed-indexed journals, focusing recent research encapsulation diverse within nanosystems exhibit responsiveness various stimuli such pH, redox potential, folate receptor levels, thereby enhancing release bioactive compounds at tumor sites. The majority cited references focus most notable research, studies novel applications, scientific advancements field nanostructures functional materials employed oncological over last six years. Certainly, there are additional potential can facilitate drug’s upon activation, reactive oxygen species (ROS), enzymes, ATP level, hypoxia; however, our exclusively addresses aforementioned presented comprehensive manner.

Язык: Английский

Cyclodextrin-Based Drug Delivery Systems for Depression: Improving Antidepressant Bioavailability and Targeted Central Nervous System Delivery DOI Creative Commons

Renata Maria Văruț,

Alin Iulian Silviu Popescu,

Simina Găman

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 355 - 355

Опубликована: Март 10, 2025

Cyclodextrin (CD)-based drug delivery systems have emerged as a promising strategy to overcome limitations commonly encountered in antidepressant therapy, including low bioavailability, poor solubility, and suboptimal penetration of the blood–brain barrier. This review synthesizes current evidence demonstrating that complexing various classes antidepressants—such tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), atypical antidepressants—with β-CD or its derivatives significantly enhances solubility stability. In addition, encapsulation with CDs can diminish systemic toxicity improve pharmacokinetics, thereby helping optimize dosage regimens reduce adverse effects. Analysis published vitro vivo studies indicates CD formulations not only boost therapeutic efficacy but also enable sustained targeted release, which is critical for drugs requiring precise plasma tissue concentrations. When compared other carriers (e.g., liposomes, polymeric nanoparticles, dendrimers), CD-based often stand out their ease formulation, biocompatibility, cost-effectiveness, although limited drug-loading capacity be drawback. We recommend expanding trials substantiate clinical benefits CD–antidepressant complexes, particularly treatment-resistant cases specific subpopulations elderly pediatric patients). Additional investigations should explore hybrid systems—combining advanced nano- macroparticles—to amplify advantages address any limitations. Ultimately, integrating into holds substantial potential refine therapy outcomes, events, pave way more personalized, effective interventions depression.

Язык: Английский

Процитировано

0
Enhancing the Solubility of Isoconazole Nitrate Using Methyl-β-Cyclodextrin: Formulation and Characterization of Inclusion Complexes DOI Creative Commons
Tarek Alloush, Gülsel Yurtdaş Kırımlıoğlu

Molecules, Год журнала: 2025, Номер 30(8), С. 1654 - 1654

Опубликована: Апрель 8, 2025

Isoconazole nitrate (ISN) is a broad-spectrum antifungal agent whose therapeutic potential limited by poor aqueous solubility and low bioavailability. This study aimed to enhance the physicochemical properties of ISN through formation inclusion complexes with methyl-β-cyclodextrin (M-β-CD) using freeze-drying (FD) spray-drying (SD) methods. The prepared were comprehensively characterized high-performance liquid chromatography (HPLC), phase analysis, scanning electron microscopy (SEM), differential calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance (1H-NMR). Phase studies revealed an AL-type diagram 1:1 molar ratio apparent stability constant (KS) 2711 M−1. Structural thermal analyses confirmed successful complex reduced crystallinity. assessment showed that ISN/M-β-CD SD exhibited approximately seven-fold higher than performed better those FD. Moreover, demonstrated drug content. These findings highlight M-β-CD-based complexation, particularly via spray-drying, as effective strategy bioavailability poorly water-soluble drugs, such ISN.

Язык: Английский

Процитировано

0
Study of Carvedilol–β-Cyclodextrin Derivatives Interactions DOI Open Access

Ema-Teodora Nițu,

Amalia Ridichie,

Claudia Temereancă

и другие.

Processes, Год журнала: 2025, Номер 13(4), С. 1141 - 1141

Опубликована: Апрель 10, 2025

Carvedilol (CARV) is a nonselective beta and alpha-1 adrenoceptor antagonist commonly indicated for chronic heart failure hypertension. Its clinical potential limited by its low aqueous solubility, resulting in poor bioavailability. Encapsulation of CARV cyclodextrins (CDs) was performed to exceed solubility-related barriers. This study examines the impact CD type ethanol, as co-solvent used preparation step, on complexation with two β-CD derivatives. The inclusion complexes (ICs) were prepared employing kneading method investigated using different analytical techniques, including thermoanalytical methods, powder X-ray diffractometry (PXRD), universal attenuated total reflectance Fourier transform infrared (UATR-FTIR) spectroscopy, UV spectroscopy saturation solubility studies. binary products heptakis(2,6-di-O-methyl)-β-cyclodextrin (DM-β-CD) randomly methylated β-cyclodextrin (RM-β-CD) exhibit thermal behavior, FTIR spectral diffractometric profiles from those parent compounds, emphasizing interaction between components IC formation. increased 1.78 3.32 times result drug CDs. Analytical data indicate significant influence both solvent systems highlighting CARV/DM-β-CD promising entity further research obtain new formulations containing improved

Язык: Английский

Процитировано

0
Advancements in Cyclodextrin Complexes with Bioactive Secondary Metabolites and Their Pharmaceutical Applications DOI Creative Commons
Oana Elena Nicolaescu, Cătălina Ionescu, Adriana Samide

и другие.

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 506 - 506

Опубликована: Апрель 11, 2025

Cyclodextrins (CDs) have largely been investigated during the last decades for their outstanding properties, such as biocompatibility and biodegradability, with wide applications in pharmaceutical field, among which formation of inclusion complexes (ICs) natural or synthetic lipophilic compounds. This review prioritizes research recent years (2022–2025), being focused on (1) systematization ICs based structure secondary metabolite, namely (i) polyphenols (PPs), (ii) terpenes terpenoids (TTs), (iii) alkaloids (Alks); (2) each type complex, following aspects discussed: benefits complexation, composite materials, vitro/in vivo theoretical studies; (3) pharmacokinetics pharmacodynamics, risks, limitations, perspectives cyclodextrin metabolites.

Язык: Английский

Процитировано

0
Smart Drug Delivery Systems Based on Cyclodextrins and Chitosan for Cancer Therapy DOI Creative Commons

Larisa Păduraru,

Alina Diana Panainte, Cătălina A. Peptu

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 564 - 564

Опубликована: Апрель 13, 2025

Despite improvements in therapeutic approaches like immunotherapy and gene therapy, cancer still remains a serious threat to world health due its high incidence mortality rates. Limitations of conventional therapy include suboptimal targeting, multidrug resistance, systemic toxicity. A major challenge current oncology therapies is the development new delivery methods for antineoplastic drugs that act directly on target. One approach involves complexation antitumor with cyclodextrins (CDs) chitosan (CS) as an attempt counteract their primary limitations: low water solubility bioavailability, diminished vitro vivo stability, dose-dependent All those drawbacks may potentially exclude some candidates from clinical trials, thus integration into smart systems or drug-targeting technologies must be implemented. We intended overview drug based regard diagnosis management. This narrative review encompasses full-length articles published English between 2019 2025 (including online ahead print versions) PubMed-indexed journals, focusing recent research encapsulation diverse within nanosystems exhibit responsiveness various stimuli such pH, redox potential, folate receptor levels, thereby enhancing release bioactive compounds at tumor sites. The majority cited references focus most notable research, studies novel applications, scientific advancements field nanostructures functional materials employed oncological over last six years. Certainly, there are additional potential can facilitate drug’s upon activation, reactive oxygen species (ROS), enzymes, ATP level, hypoxia; however, our exclusively addresses aforementioned presented comprehensive manner.

Язык: Английский

Процитировано

0