Safety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza and COVID-19 in Golden Syrian Hamsters DOI Creative Commons
Ekaterina Stepanova, Victoria Matyushenko, Daria A Mezhenskaia

и другие.

Vaccines, Год журнала: 2024, Номер 12(12), С. 1300 - 1300

Опубликована: Ноя. 21, 2024

Background/Objectives: Influenza viruses and SARS-CoV-2 are currently cocirculating with similar seasonality, both pathogens characterized by a high mutational rate which results in reduced vaccine effectiveness thus requires regular updating of compositions. Vaccine formulations combining seasonal influenza strains can be considered promising cost-effective tools for protection against infections. Methods: We used licensed trivalent live attenuated (3×LAIV) as basis the development modified 3×LAIV/CoV-2 vaccine, where H1N1 H3N2 LAIV encoded an immunogenic cassette enriched conserved T-cell epitopes SARS-CoV-2, whereas B/Victoria lineage strain was unmodified. The LAIV/CoV-2 composition compared to classical 3×LAIV golden Syrian hamster model. Animals were intranasally immunized mixtures viruses, twice, 3-week interval. Immunogenicity assessed on day 42 study, protective effect established infecting vaccinated hamsters either H1N1, or B Wuhan, Delta Omicron lineages. Results: Both compositions induced levels serum antibodies specific all three strains, resulted comparable challenge from strain. Protection more pronounced 3×LAIV/CoV-2-immunized group. These data accompanied higher magnitude virus-specific cellular responses detected ELISPOT Conclusions: encoding tool combined COVID-19.

Язык: Английский

Adult Vaccine Coadministration Is Safe, Effective, and Acceptable: Results of a Survey of the Literature DOI Creative Commons
Litjen Tan,

Dana Trevas,

Ann R. Falsey

и другие.

Influenza and Other Respiratory Viruses, Год журнала: 2025, Номер 19(3)

Опубликована: Март 1, 2025

Coadministration of vaccines in children is a long-standing practice that has proven to be safe and effective improving the efficiency vaccine administration, thereby increasing immunization coverage rates. As number routinely recommended for adults increases, with limited opportunities have preventive health touchpoints providers, adult coadministration should considered as routine improve vaccination rates public health. A review existing literature was conducted examine potential reactogenicity impact on effectiveness when co-administering adults. Medline searched research articles search term "influenza vaccine" or "vaccination," combined terms "simultaneous," "concomitant," "concurrent," "combination." Another "vaccination" following individual terms: "RSV," "COVID," "Tdap." The references extracted were also examined other relevant articles. Adult all combinations we assessed. Most adverse events (AEs) generally mild moderate short duration. Some studies showed slightly more but few no serious AEs safety signals. Nearly every study confirmed had significant effect immune response either vaccine. benefits outweigh risks. It increases convenience vaccinees, reduces missed vaccinate, contributes efficient use healthcare resources.

Язык: Английский

Процитировано

1
Co-Administration of Influenza and COVID-19 Vaccines: A Cross-Sectional Survey of Canadian Adults’ Knowledge, Attitudes, and Beliefs DOI Creative Commons
Sherilyn K. D. Houle, Ajit Johal,

Paul Roumeliotis

и другие.

Pharmacy, Год журнала: 2024, Номер 12(2), С. 70 - 70

Опубликована: Апрель 17, 2024

Vaccination rates against both influenza and COVID-19 fall short of targets, especially among persons at risk complications. To gain insights into strategies to boost vaccine coverage, we surveyed 3000 Canadian residents aged ≥ 18 years examined their knowledge receipt co-administered vaccines. During the 2022–2023 season, 70% respondents reported being aware vaccines could be co-administered, but only 26.2% (95% CI, 23.6% 28.8%) received them together. The most common reason for not getting together was before annual available (reported by 34.5% [31.2% 37.7%]). Lack interest in co-administration 22.6% (20.8% 24.3%); this group, 20.8% (17.1% 24.5%) seeing no benefit receiving two 17.2% (13.5% 20.9%) were concerned about compounded adverse effects from These results support willingness Canadians receive same time. Co-administration is a viable strategy improve uptake vaccines, if health professionals proactively offer education (or other) as appropriate clinical need.

Язык: Английский

Процитировано

5
Adult influenza vaccination coverage before, during and after the COVID-19 pandemic in Canada DOI Creative Commons
Ruoke Chen, Nicolas L. Gilbert, Ève Dubé

и другие.

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Дек. 2, 2024

Abstract Background Vaccination prevents seasonal influenza and its complications, particularly among high-risk populations. The COVID-19 pandemic has been reported to impact healthcare behaviors vaccination patterns. This study aims assess coverage changes in settings Canadian adults from the 2018–2019 2023–2024 seasons. Method We conducted a retrospective analysis of data multiple cycles Seasonal Influenza Coverage Survey (SIVCS). was examined across different seasons, stratified by population groups. Odds ratios (ORs) were calculated compare likelihoods with serving as reference. Chi-square tests applied determine whether there significant differences place since pre-pandemic season. Results When comparing vaccine uptake before, during after pandemic, we observed temporary decline 2021–2022 season (OR = 0.882, 95% CI 0.787–0.988) compared 2018–2019. By 2022–2023 returned levels. aged 18–64 without chronic medical condition consistently remained lower than other places shifted markedly, pharmacies becoming predominant site, increasing 35.4% 57.4% 2023–2024, while doctor’s offices saw 32.7 15.2% over same period. Conclusion Our findings highlight transient effect on flu Canada. use for vaccinations underscores importance accessible convenient sites. Future efforts should focus maintaining improving through diverse adaptable settings.

Язык: Английский

Процитировано

2
Attitudes, Beliefs, and Self-Reported Rates of Influenza and COVID-19 Vaccinations in the Canadian 2023–2024 National Influenza and Respiratory Viruses Survey DOI Creative Commons
Samir K. Sinha,

Natalie Iciaszczyk,

Bertrand Le Roy

и другие.

Vaccines, Год журнала: 2024, Номер 12(11), С. 1230 - 1230

Опубликована: Окт. 29, 2024

Background: We conducted a cross-sectional, online survey of adult Canadian residents to evaluate their attitudes and beliefs about vaccination against respiratory viruses, particularly influenza coronavirus 2019 (COVID-19). Methodology: Survey participants aged ≥ 18 years were randomly recruited from the Léger Opinion (LEO) consumer panel. Results: Out 3002 respondents, 76% reported being “up-to-date” on all recommended vaccinations, 86% understanding why vaccine was needed annually, 79% believing safe, 83% that vaccines, in general, important for health. However, only 49% receiving fall 2023, 46% received COVID-19 (68% those who one other). More than half respondents (55%) they found it difficult keep track which vaccines them, while 74% indicated valued opinion healthcare provider (HCP) when deciding whether be vaccinated influenza, 73% said would not hesitate receive multiple at same time if HCP it. Conclusions: These findings highlight ongoing need education outreach Canada.

Язык: Английский

Процитировано

0
Safety, Immunogenicity and Protective Activity of a Modified Trivalent Live Attenuated Influenza Vaccine for Combined Protection Against Seasonal Influenza and COVID-19 in Golden Syrian Hamsters DOI Creative Commons
Ekaterina Stepanova, Victoria Matyushenko, Daria A Mezhenskaia

и другие.

Vaccines, Год журнала: 2024, Номер 12(12), С. 1300 - 1300

Опубликована: Ноя. 21, 2024

Background/Objectives: Influenza viruses and SARS-CoV-2 are currently cocirculating with similar seasonality, both pathogens characterized by a high mutational rate which results in reduced vaccine effectiveness thus requires regular updating of compositions. Vaccine formulations combining seasonal influenza strains can be considered promising cost-effective tools for protection against infections. Methods: We used licensed trivalent live attenuated (3×LAIV) as basis the development modified 3×LAIV/CoV-2 vaccine, where H1N1 H3N2 LAIV encoded an immunogenic cassette enriched conserved T-cell epitopes SARS-CoV-2, whereas B/Victoria lineage strain was unmodified. The LAIV/CoV-2 composition compared to classical 3×LAIV golden Syrian hamster model. Animals were intranasally immunized mixtures viruses, twice, 3-week interval. Immunogenicity assessed on day 42 study, protective effect established infecting vaccinated hamsters either H1N1, or B Wuhan, Delta Omicron lineages. Results: Both compositions induced levels serum antibodies specific all three strains, resulted comparable challenge from strain. Protection more pronounced 3×LAIV/CoV-2-immunized group. These data accompanied higher magnitude virus-specific cellular responses detected ELISPOT Conclusions: encoding tool combined COVID-19.

Язык: Английский

Процитировано

0