The Pathophysiology and Biomarkers of Delirium DOI
Courtney Smith,

Dee Hodge,

Fiona E. Harrison

и другие.

Seminars in Neurology, Год журнала: 2024, Номер 44(06), С. 720 - 731

Опубликована: Окт. 17, 2024

Delirium is a major disturbance in the mental state characterized by fluctuations arousal, deficits attention, distorted perception, and disruptions memory cognitive processing. affects approximately 18% to 25% of hospital inpatients, with even higher rates observed during critical illness. To develop therapies shorten duration limit adverse effects delirium, it important understand mechanisms underlying its presentation. Neuroimaging modalities such as magnetic resonance imaging (MRI), positron emission tomography, functional MRI, near-infrared spectroscopy point global atrophy, white matter changes, cerebral blood flow, oxygenation, metabolism, connectivity key correlates delirium pathogenesis. Electroencephalography demonstrates generalized slowing normal background activity, pathologic decreases variability oscillatory patterns among specific brain regions. Elevated serum biomarkers inflammation, including interleukin-6, C-reactive protein, S100B, suggest role dysregulated inflammatory processes cellular particularly perioperative sepsis-related delirium. Emerging animal models that can mimic delirium-like clinical states will reveal further insights into pathophysiology. The combination basic science methods exploring shows great promise elucidating revealing potential therapeutic targets.

Язык: Английский

The Pathophysiology and Biomarkers of Delirium DOI
Courtney Smith,

Dee Hodge,

Fiona E. Harrison

и другие.

Seminars in Neurology, Год журнала: 2024, Номер 44(06), С. 720 - 731

Опубликована: Окт. 17, 2024

Delirium is a major disturbance in the mental state characterized by fluctuations arousal, deficits attention, distorted perception, and disruptions memory cognitive processing. affects approximately 18% to 25% of hospital inpatients, with even higher rates observed during critical illness. To develop therapies shorten duration limit adverse effects delirium, it important understand mechanisms underlying its presentation. Neuroimaging modalities such as magnetic resonance imaging (MRI), positron emission tomography, functional MRI, near-infrared spectroscopy point global atrophy, white matter changes, cerebral blood flow, oxygenation, metabolism, connectivity key correlates delirium pathogenesis. Electroencephalography demonstrates generalized slowing normal background activity, pathologic decreases variability oscillatory patterns among specific brain regions. Elevated serum biomarkers inflammation, including interleukin-6, C-reactive protein, S100B, suggest role dysregulated inflammatory processes cellular particularly perioperative sepsis-related delirium. Emerging animal models that can mimic delirium-like clinical states will reveal further insights into pathophysiology. The combination basic science methods exploring shows great promise elucidating revealing potential therapeutic targets.

Язык: Английский

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